Viruses, Vol. 16, Pages 663: Mechanisms by Which SARS-CoV-2 Invades and Damages the Central Nervous System: Apart from the Immune Response and Inflammatory Storm, What Else Do We Know?
n Jin
Initially reported as pneumonia of unknown origin, COVID-19 is increasingly being recognized for its impact on the nervous system, despite nervous system invasions being extremely rare. As a result, numerous studies have been conducted to elucidate the mechanisms of nervous system damage and propose appropriate coping strategies. This review summarizes the mechanisms by which SARS-CoV-2 invades and damages the central nervous system, with a specific focus on aspects apart from the immune response and inflammatory storm. The latest research findings on these mechanisms are presented, providing new insights for fur...
Source: Viruses - April 24, 2024 Category: Virology Authors: Zihan Sun Chunying Shi Lixin Jin Tags: Review Source Type: research
Neuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study
ConclusionNeuropsychiatric complications of COVID-19, especially AMS, were common, varied, and associated with in-hospital mortality in a diverse multicenter cohort at an epicenter of the COVID-19 pandemic. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Safety of Biologics and Small Molecules for Inflammatory Bowel Diseases in Organ Transplant Recipients
CONCLUSION: The use of biologics or small molecules for patients with IBD who received organ transplants did not show a significant difference in safety outcomes. However, the possibility of severe infections must be considered.PMID:38653566 | DOI:10.3349/ymj.2023.0361 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Ga Hee Kim Minjun Kim Kyuwon Kim Jung-Bin Park Ji Eun Baek June Hwa Bae Seung Wook Hong Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park Source Type: research
Using the ROX Index to Predict Treatment Outcome for High-Flow Nasal Cannula and/or Noninvasive Ventilation in Patients With COPD Exacerbations
CONCLUSIONS: The ROX index applied to adults with COPD exacerbations treated with HFNC and/or NIV required higher scores to achieve similar prediction of low risk of treatment failure when compared to subjects with hypoxemic respiratory failure/pneumonia. ROX scores < 4.88 did not accurately predict intubation or death.PMID:38653556 | DOI:10.4187/respcare.11544 (Source: Respiratory Care)
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: Brett Z Schaeffer Sarina A Fazio Jacqueline C Stocking Jason Y Adams Anna Liu Hugh B Black Richart W Harper Irene Cortes-Puch Timothy E Albertson Brooks T Kuhn Source Type: research
Evaluation of omadacycline regimens for community-acquired bacterial pneumonia patients infected with < em > Staphylococcus Aureus < /em > by pharmacokinetic/pharmacodynamic analysis
J Chemother. 2024 Apr 22:1-8. doi: 10.1080/1120009X.2024.2343963. Online ahead of print.ABSTRACTOmadacycline is an FDA-approved agent for community-acquired bacterial pneumonia (CABP). The purpose of this study is to evaluate the effectiveness of omadacycline for treating CABP patients infected with Staphylococcus aureus, including Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Susceptible Staphylococcus aureus (MSSA), using pharmacokinetic/pharmacodynamic (PK/PD) analysis. Monte Carlo simulations (MCSs) were performed by utilizing omadacycline pharmacokinetic (PK) parameters, minimum inhibitory concent...
Source: Journal of Chemotherapy - April 23, 2024 Category: Cancer & Oncology Authors: Gaoqi Xu Xin Liu Jiaqi Wang Yuqing Mei Dihong Yang Chaoneng He Like Zhong Junfeng Zhu Haiying Ding Luo Fang Source Type: research
Veno-venous extracorporeal membrane oxygenation for covid-19 in postpartum patients: 1-year outcome
During the pandemic, a significant number of patients with severe COVID-19 pneumonia required intensive care. Among these, peripartum women were particularly susceptible to severe respiratory symptoms. This complex pathophysiology involves mechanical and hormonal pathways, including the presence of lung restriction 1, modulation of the immune system by pregnancy 2, and increased oxygen demand 3. Additionally, a high level of vaccine hesitancy in this population meant that most pregnant women were not vaccinated during the COVID-19 pandemic 4. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 23, 2024 Category: Anesthesiology Authors: Alexandra P álfi, Éva Zöllei, Zoltán Varga, László B. Tomozi, Domonkos Schulcz, Gábor Bari, Ferenc Peták, Fruzsina Kun-Szabó, Kristóf Baráth, László Rudas, Ádám L. Balogh, Barna Babik Tags: Case Report Source Type: research
Anti-spike antibody level is associated with the risk of clinical progression among subjects hospitalized with COVID-19 pneumonia: results from a retrospective cohort study
ConclusionThis study suggests that levels of anti-S antibodies can predict critical or fatal outcomes in COVID-19 pneumonia patients, regardless of vaccination. Whether anti-S Ab could guide risk assessment and vaccination boosting merits further evaluation. (Source: Infection)
Source: Infection - April 23, 2024 Category: Infectious Diseases Source Type: research
Frequency, complications, and mortality of inhalation injury in burn patients: A systematic review and meta-analysis protocol
DiscussionDespite the extensive experience managing IIs in burn patients, they still represent an important cause of morbidity and mortality. Diagnosis and accurate measurement of its damage are complex, and therapies are essentially based on supportive measures. Considering the challenge, their impact, and their potential severity, IIs represent a promising area for research, needing further studies to understand and contribute to its better evolution.The protocol of this review is registered on the International prospective register of systematic reviews platform of the Center for Revisions and Disclosure of the Universi...
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Juliana Elvira Herdy Guerra Avila Source Type: research
No evidence of difference in mortality with amoxicillin versus co-amoxiclav for hospital treatment of community-acquired pneumonia
Current guidelines recommend broad-spectrum antibiotics for high-severity community-acquired pneumonia (CAP), potentially contributing to antimicrobial resistance (AMR). We aim to compare outcomes in CAP patients treated with amoxicillin (narrow-spectrum) versus co-amoxiclav (broad-spectrum), to understand if narrow-spectrum antibiotics could be used more widely. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Jia Wei, Aashna Uppal, Christy Nganjimi, Hermione Warr, Yasin Ibrahim, Qingze Gu, Hang Yuan, Najib M Rahman, Nicola Jones, A Sarah Walker, David W Eyre Source Type: research
Changing clinical characteristics of pediatric inpatients with pneumonia during COVID-19 pandamic: a retrospective study
This study aimed to compare the pathogen, allergen and micronutrient characteristics of pediatric inpatien... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 23, 2024 Category: Pediatrics Authors: Mengxue Chen, Yabing Zhou, Shengjie Jin, Shasha Bai, Xiaoyu Tang, Quanhua Liu, Liwei Wang, Ruoxu Ji, Haipei Liu, Wenwei Zhong, Yi Chen, Dingzhu Fang, Jianhua Zhang and Li Hua Tags: Research Source Type: research
Emergency department imaging utilization post-transcatheter aortic valve replacement: single institution 7-year experience
ConclusionOur study highlights the vital role of early and accurate imaging in post-TAVR patients within 30 days post-procedure. As transcatheter approaches rise in popularity, emergency radiologists become instrumental in diagnosing common post-procedural presentations. Continued research is essential to devise post-discharge strategies to curtail readmissions and related costs. Proper imaging ensures prompt, effective care, enhancing overall patient outcomes. (Source: Emergency Radiology)
Source: Emergency Radiology - April 23, 2024 Category: Emergency Medicine Source Type: research
Changing clinical characteristics of pediatric inpatients with pneumonia during COVID-19 pandamic: a retrospective study
ConclusionsThe number of children hospitalized with pneumonia and incidence of common pathogen infections were both reduced, and that allergy and micronutrient status in children were also changed after the outbreak of the COVID-19 pandemic. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 23, 2024 Category: Pediatrics Source Type: research
Factors Associated With Time to Decannulation in Patients With Tracheostomy Following Severe Traumatic Brain Injury
CONCLUSIONS: This study found that a change in swallowing ability is a potentially significant factor for reducing time to decannulation. Identifying factors that could explain differences in time to decannulation is essential for patient outcomes, especially if these factors are modifiable and could be targeted in rehabilitation and treatment.PMID:38649274 | DOI:10.4187/respcare.11376 (Source: Respiratory Care)
Source: Respiratory Care - April 22, 2024 Category: Respiratory Medicine Authors: Signe J Eskildsen Carrinna A Hansen Thomas Kallemose Derek J Curtis Irene Wessel Ingrid Poulsen Source Type: research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Department
CONCLUSIONS D-dimer and NT-proBNP, but not troponin T, are useful in differentiating CVDs in patients with COVID-19. ACS with COVID-19 increased in-hospital mortality independently from extent of lung involvement, while coexisting APE or AMyo did not.PMID:38644597 | DOI:10.12659/MSM.942612 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 22, 2024 Category: Research Authors: Micha ł Machowski Aisha Ou-Pokrzewi ńska Katarzyna Perzanowska-Brzeszkiewicz Magdalena Ga łecka-Nowak Szymon Pacho Mateusz Jermakow Agnieszka W ójcik Milena Zoruk Andrzej Pruszczyk Karol Deutsch Marek Roik Andrzej Łabyk Piotr Palczewski Piotr Pruszcz Source Type: research
Epstein-Barr virus, Cytomegalovirus, and Herpes Simplex-1/2 reactivations in critically ill patients with COVID-19
CONCLUSIONS: Human Herpesviruses reactivations in critically ill patients with COVID-19 severe Pneumonia are associated with mortality and with a higher risk to develop both VAP and ICU-BSI.PMID:38649512 | DOI:10.1186/s40635-024-00624-9 (Source: Herpes)
Source: Herpes - April 22, 2024 Category: Infectious Diseases Authors: Alessia Mattei Lorenzo Schiavoni Elisabetta Riva Massimo Ciccozzi Roberta Veralli Angela Urselli Vincenzo Citriniti Antonio Nenna Giuseppe Pascarella Fabio Costa Rita Cataldo Felice Eugenio Agr ò Massimiliano Carassiti Source Type: research
