Genetics and Genomics of Pulmonary Fibrosis: Charting the Molecular Landscape and Shaping Precision Medicine
Am J Respir Crit Care Med. 2024 Apr 4. doi: 10.1164/rccm.202401-0238SO. Online ahead of print.ABSTRACTRecent genetic and genomic advancements have elucidated the complex etiology of idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases (ILDs), emphasizing the contribution of heritable factors. This state-of-the-art review synthesizes evidence on significant genetic contributors to pulmonary fibrosis (PF), including rare genetic variants and common single nucleotide polymorphisms (SNPs). The MUC5B promoter variant is unusual, a common SNP that markedly elevates the risk of early and e...
Source: Am J Respir Crit Car... - April 4, 2024 Category: Intensive Care Authors: Ayodeji Adegunsoye Jonathan A Kropski Juergen Behr Timothy S Blackwell Tamera J Corte Vincent Cottin Allan Glanville Marilyn K Glassberg Matthias Griese Gary M Hunninghake Kerri A Johannson Michael P Keane John S Kim Martin Kolb Toby M Maher Justin M Oldh Source Type: research
Genetics and Genomics of Pulmonary Fibrosis: Charting the Molecular Landscape and Shaping Precision Medicine
Am J Respir Crit Care Med. 2024 Apr 4. doi: 10.1164/rccm.202401-0238SO. Online ahead of print.ABSTRACTRecent genetic and genomic advancements have elucidated the complex etiology of idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases (ILDs), emphasizing the contribution of heritable factors. This state-of-the-art review synthesizes evidence on significant genetic contributors to pulmonary fibrosis (PF), including rare genetic variants and common single nucleotide polymorphisms (SNPs). The MUC5B promoter variant is unusual, a common SNP that markedly elevates the risk of early and e...
Source: Respiratory Care - April 4, 2024 Category: Respiratory Medicine Authors: Ayodeji Adegunsoye Jonathan A Kropski Juergen Behr Timothy S Blackwell Tamera J Corte Vincent Cottin Allan Glanville Marilyn K Glassberg Matthias Griese Gary M Hunninghake Kerri A Johannson Michael P Keane John S Kim Martin Kolb Toby M Maher Justin M Oldh Source Type: research
Genetics and Genomics of Pulmonary Fibrosis: Charting the Molecular Landscape and Shaping Precision Medicine
Am J Respir Crit Care Med. 2024 Apr 4. doi: 10.1164/rccm.202401-0238SO. Online ahead of print.ABSTRACTRecent genetic and genomic advancements have elucidated the complex etiology of idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases (ILDs), emphasizing the contribution of heritable factors. This state-of-the-art review synthesizes evidence on significant genetic contributors to pulmonary fibrosis (PF), including rare genetic variants and common single nucleotide polymorphisms (SNPs). The MUC5B promoter variant is unusual, a common SNP that markedly elevates the risk of early and e...
Source: American Journal of Respiratory and Critical Care Medicine - April 4, 2024 Category: Respiratory Medicine Authors: Ayodeji Adegunsoye Jonathan A Kropski Juergen Behr Timothy S Blackwell Tamera J Corte Vincent Cottin Allan Glanville Marilyn K Glassberg Matthias Griese Gary M Hunninghake Kerri A Johannson Michael P Keane John S Kim Martin Kolb Toby M Maher Justin M Oldh Source Type: research
IL-10 Counteracts IFN- γ to Alleviate Acute Lung Injury in a Viral-Bacterial Superinfection Model
Am J Respir Cell Mol Biol. 2024 Apr 4. doi: 10.1165/rcmb.2023-0437OC. Online ahead of print.ABSTRACTImmune activation is essential for lung control of viral and bacterial infection, but an overwhelming inflammatory response often leads to the onset of acute respiratory distress syndrome (ARDS). Interleukin-10 (IL-10) plays a crucial role in regulating the balance between antimicrobial immunity and immunopathology. In the current study, we have investigated the role of IL-10 in acute lung injury (ALI) induced by influenza A virus (IAV) and methicillin-resistant Staphylococcus aureus (MRSA) coinfection. This unique coinfecti...
Source: Am J Respir Cell Mol... - April 4, 2024 Category: Respiratory Medicine Authors: Michael McKelvey Md Bashir Uddin Sunil Palani Shengjun Shao Keer Sun Source Type: research
Identification of connective tissue disease autoantibodies and a novel autoantibody anti-annexin A11 in patients with "idiopathic" interstitial lung disease
CONCLUSION: Specific guidance on autoantibody testing and interpretation in patients with ILD could improve diagnostic accuracy. Further work is required to determine the clinical significance of anti-annexin A11.PMID:38575043 | DOI:10.1016/j.clim.2024.110201 (Source: Clinical Immunology)
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Sarah L Tansley Fionnuala McMorrow Caroline V Cotton Huzaifa Adamali Shaney L Barratt Zoe E Betteridge Janire Perurena-Prieto Michael A Gibbons Raman Kular Aravinthan Loganathan Janine A Lamb Hui Lu Robert P New Diane Pratt Pilar Rivera-Ortega Ross Sayers Source Type: research
