Transcriptome of bone marrow-Derived stem cells reveals new inflammatory mediators related to increased survival in patients with multiple myeloma
Cytokine. 2024 Apr 20;179:156613. doi: 10.1016/j.cyto.2024.156613. Online ahead of print.ABSTRACTAlthough multiple myeloma (MM) is a neoplasm that leads affected individuals to death, little is known about why some patients survive much longer than others. In this context, we investigated the transcriptomic profile of bone marrow hematopoietic stem cells obtained from MM patients and compared the clinical outcomes of death and survival six months after bone marrow transplantation. The leukapheresis products of 39 patients with MM eligible for autologous transplantation were collected and analyzed. After extraction, the RNA...
Source: Cytokine - April 21, 2024 Category: Molecular Biology Authors: Stefania Tagliari de Oliveira Renata Binato Geise Ellen Broto Erika Tomie Takakura Leticia Navarro Gordan Ferreira Martins Eliana Abdelhay Carolina Panis Source Type: research
Solitary Bone Plasmacytoma of the Skull Base With an Unusual Presentation
We present the case of a 61-year-old man with an unusual presentation of hoarseness secondary to vocal fold palsy. Imaging showed a large bony lesion in the temporo-occipital region with involvement of the jugular foramen. Further detailed diagnostic procedures confirmed SBP of the skull base. Radiotherapy was given with an uneventful recovery of vocal fold function. Skull base plasmacytoma can be considered as a differential diagnosis of causes of unilateral vocal fold palsy. Early therapeutic management may improve vocal fold function.PMID:38634321 | DOI:10.1177/01455613241249039 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 18, 2024 Category: ENT & OMF Authors: Tien-Ru Huang Chun-Shu Lin Hsin-Chien Chen Source Type: research
Solitary Bone Plasmacytoma of the Skull Base With an Unusual Presentation
We present the case of a 61-year-old man with an unusual presentation of hoarseness secondary to vocal fold palsy. Imaging showed a large bony lesion in the temporo-occipital region with involvement of the jugular foramen. Further detailed diagnostic procedures confirmed SBP of the skull base. Radiotherapy was given with an uneventful recovery of vocal fold function. Skull base plasmacytoma can be considered as a differential diagnosis of causes of unilateral vocal fold palsy. Early therapeutic management may improve vocal fold function.PMID:38634321 | DOI:10.1177/01455613241249039 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 18, 2024 Category: ENT & OMF Authors: Tien-Ru Huang Chun-Shu Lin Hsin-Chien Chen Source Type: research
Amyloid Secreting Jejunal Plasmacytoma
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - April 16, 2024 Category: Hematology Source Type: research
Spontaneous regression of multiple solitary plasmacytoma harboring Epstein-Barr virus: a case report and literature review
We report a rare case of spontaneous regression (SR) in an elderly untreated patient with multiple solitary plasmacytoma (MSP). Diagnosis of MSP was confirmed through surgical resection of the left nasal cavity mass and subsequent biopsy of the right humerus. The patient was considered ineligible for chemotherapy due to poor performance status. At 3-month post-diagnosis, the patient's condition worsened with deteriorating bone lesions and emergence of a new serum monoclonal protein. However, these clinical findings completely disappeared at 6 months, and positron emission tomography-computed tomography at 1 year confirmed ...
Source: International Journal of Hematology - April 15, 2024 Category: Hematology Authors: Wataru Kitamura Hiroki Kobayashi Minori Noda Akiko Iseki Yumi Sato Yoshinobu Maeda Shoichi Kuyama Source Type: research
Solitary bone plasmacytoma: Long-term clinical outcomes in a single center
CONCLUSION: This study confirmed the high rate of progression of SBP to MM, indicating a need for adjunct chemotherapy for the management of SBP.PMID:38598973 | DOI:10.1016/j.currproblcancer.2024.101095 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Shan Gao Yu-Tong Wang Guang-Yu Ma Min-Qiu Lu Bin Chu Lei Shi Li-Juan Fang Qiu-Qing Xiang Yue-Hua Ding Li Bao Source Type: research
Development and validation of a machine learning-based postoperative prognostic model for plasma cell neoplasia with spinal lesions as initial clinical manifestations: a single-center cohort study
ConclusionsThe GNB model has the best performance and high reliability in predicting postoperative outcomes. Variables such as ISS stage and DS stage were significant in influencing patient prognosis. This study enhances the ability to identify patients at risk of poor outcomes, thereby aiding clinical decision-making. (Source: European Spine Journal)
Source: European Spine Journal - April 7, 2024 Category: Orthopaedics Source Type: research
A case of autoimmune encephalitis in a patient with a solitary intracranial plasmacytoma
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2888-23. Online ahead of print.ABSTRACTA 65-year-old woman presented with fever and abnormal behavior. Magnetic resonance imaging showed swelling of the left medial temporal lobe and an intracranial extra-axial occipital tumor. While her neurological symptoms improved after the administration of corticosteroid therapy under the suspicion of autoimmune encephalitis, the occipital tumor unexpectedly shrank, and the diagnosis of a solitary plasmacytoma was confirmed by biopsy. Additional examinations revealed elevated anti-glutamate receptor antibodies in the cerebrospinal...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Keisuke Mizutani Keita Sakurai Yuto Uchida Ken Hashimoto Tomohiro Kajiguchi Yukitoshi Takahashi Hiroyuki Yuasa Koji Takada Noriyuki Matsukawa Source Type: research
Extramedullary plasmacytoma of the larynx - Case report
The objective of this clinical case report is to highlight the diagnosis and management of a unique case such as this. A 77-year-old gentleman presented with complaints of hoarseness for 1 year. Computed tomography image revealed a soft tissue mass lesion involving the right true vocal cord. Direct laryngoscopic biopsy was performed and subjected to histopathological examination, which showed collection of plasma cells. Immunohistochemistry confirmed the presence of Kappa and Lambda cells. Multiple myeloma (MM) was ruled out. The patient received radical intent radiation therapy using 3DCRT technique with a dose of 50Gy in...
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Ajinkya Gupte Ajay Sasidharan Debnarayan Dutta R Anoop Source Type: research
Recurrence of solitary plasmacytoma in the liver 10 years after the onset of multiple bone lesions
J Clin Exp Hematop. 2024;64(1):65-70. doi: 10.3960/jslrt.23056.ABSTRACTA 79-year-old man presented with a history of solitary plasmacytoma in the bone 10 years ago. Chemoradiotherapy was effective, and remission was maintained with intermittent treatment at relapse of the bone lesions. One year after the last treatment, a follow-up computed tomography (CT) scan revealed multiple liver masses, and a liver biopsy revealed plasmacytoma. There was no clonal plasma cell infiltration in the bone marrow, and the final diagnosis was solitary plasmacytomas of the liver. Although liver involvement is known in relapsed refractory mul...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Jun Numata Hiroko Tsunemine Asuka Imai Naokazu Nakamura Tomomi Sakai Tomoo Itoh Nobuyoshi Arima Source Type: research
