Early ototoxicity in children after craniospinal irradiation using pencil beam proton therapy
In this study the role of pencil beam proton therapy (PBS) in reducing the doses to the cochlea in children receiving CSI and correlation to the early ototoxicity are analysed. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 23, 2019 Category: Radiology Authors: R. Frakulli, S. Nagaraja, T. Steinmeier, V. Ashykhmina, P.H. Kramer, C. Blase, S. Tippelt, D. Geismar, B. Timmermann Source Type: research
[Role of CT in diagnosis and monitoring of retinoblastoma in Senegal].
CONCLUSION: CT is a good alternative to MRI in the diagnosis of retinoblastoma in developing countries with limited technological resources.
PMID: 31561918 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - September 30, 2019 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Outcome and prognostic features in paediatric pineoblastomas: analysis of cases from the Surveillance, Epidemiology, and End Results registry (1990 –2007)
ConclusionThis study represents the largest analysis of paediatric pineoblastomas to date. The only clinically relevant prognostic factor was older age at diagnosis. The role of surgery and adjuvant radiotherapy on overall survival remains to be defined. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - August 22, 2019 Category: Neurosurgery Source Type: research
Tandem high-dose chemotherapy with topotecan –thiotepa–carboplatin and melphalan–etoposide–carboplatin regimens for pediatric high-risk brain tumors
ConclusionsAlthough tandem HDC/auto-SCT with TTC/MEC regimens showed promising survival rates, treatment modifications are warranted to reduce toxicities. The survival rates with relapsed brain tumors were unsatisfactory despite HDC/auto-SCT, and further study is needed. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - July 26, 2019 Category: Cancer & Oncology Source Type: research
Pineoblastomas: A long-term follow up study of three cases in Helsinki Neurosurgery
ConclusionsA proper multidisciplinary management of pineoblastomas, which associates gross total microsurgical resection of the lesion and an adjuvant therapy determined by our neurooncology team based on accurate craniospinal adjuvant radiotherapy with boost of radiation on the tumoral bed, and when needed, an adequate but aggressive medulloblastoma-like chemotherapy, may improve the overall survival of these malignant lesions. (Source: Interdisciplinary Neurosurgery)
Source: Interdisciplinary Neurosurgery - June 2, 2019 Category: Neurosurgery Source Type: research
Stereotactic Radiosurgery for Pineal Region Tumors.
Authors: Mathieu D, Iorio-Morin C
Abstract
Pineal region tumors represent a heterogeneous group of different histologic entities, for which the management can be a significant challenge, due to their critical location and frequent aggressive behavior. Traditional management includes surgical resection, fractionated radiation therapy, and chemotherapy. Stereotactic radiosurgery (SRS) is being increasingly used in the treatment of these tumors. It is used as primary therapy for pineocytomas and papillary tumors of the pineal region, as an adjuvant radiation boost in combination with radiation or chemotherapy...
Source: Progress in Neurological Surgery - May 18, 2019 Category: Neurosurgery Tags: Prog Neurol Surg Source Type: research
Primary pineal tumors & #8211; Unraveling histological challenges and certain clinical myths
Conclusion: PPTIDs are the most common adult primary PPTs and have the potential to progress and disseminate in both grades II and III. Both grades of PTPRs have a metastatic potential. These findings suggest the need for postoperative adjuvant therapy in both grades of PPTID and PTPR. (Source: Neurology India)
Source: Neurology India - May 12, 2019 Category: Neurology Authors: Anuj Verma Sridhar Epari David Bakiratharajan Ayushi Sahay Naina Goel Girish Chinnaswamy Prakash Shetty Aliasgar Moiyadi Atul Goel Tejpal Gupta Rakesh Jalali Source Type: research
Nivolumab in the Treatment of Recurrent or Refractory Pediatric Brain Tumors: A Single Institutional Experience
Successful use of immune checkpoint inhibitors in a variety of cancers has generated interest in using this approach in pediatric brain tumors. We performed a retrospective review of 10 consecutive children (6 boys, 4 girls; ages, 2 to 17 y), with recurrent or refractory pediatric brain tumors (5 high-grade glioma, 1 low-grade glioma, pineoblastoma, medulloblastoma, ependymoma, and CNS embryonal tumor, NOS) treated at Rady Children’s Hospital San Diego from 2015 to 2017 with the immune checkpoint inhibitor nivolumab (3 mg/kg every 2 wk). Eight of 10 patients received prior chemotherapy and 9 radiation therapy. Nine...
Source: Journal of Pediatric Hematology Oncology - April 24, 2019 Category: Hematology Tags: Online Articles: Original Articles Source Type: research
An update on the central nervous system manifestations of DICER1 syndrome
AbstractDICER1 syndrome is a rare tumor predisposition syndrome with manifestations that predominantly affect children and young adults. The syndrome is typically caused by heterozygous germline loss-of-functionDICER1 alterations accompanied on the other allele by somatic missense mutations occurring at one of a few mutation hotspots within the sequence encoding the RNase IIIb domain.DICER1 encodes a member of the microRNA biogenesis machinery. The syndrome spectrum is highly pleiotropic and features a unique constellation of benign and malignant neoplastic and dysplastic lesions. Pleuropulmonary blastoma (PPB), the most...
Source: Acta Neuropathologica - April 4, 2019 Category: Neurology Source Type: research
Sexsomnia in an Adolescent
We present a case of an adolescent boy with a history of resected and treated pineoblastoma who later developed sexsomnia marked by multiple episodes of masturbatory events per night. He had additional suspicions of obstructive sleep apnea. Polysomnography confirmed severe obstructive sleep apnea and captured multiple episodes of sexsomnia from both REM and NREM sleep. The patient also had daytime symptoms of severe anxiety and hypersomnia that required pharmacological intervention, cognitive behavioral techniques, and hypnosis. The patient showed improvement with hypnosis along with a multimodal approach to the treatment ...
Source: Journal of Clinical Sleep Medicine : JCSM - March 15, 2019 Category: Sleep Medicine Source Type: research
Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - March 13, 2019 Category: Neurology Source Type: research
An Active Duty Sailor With Worsening Headaches and Blurry Vision.
Authors: Thompson CA, Barnes E
Abstract
Headaches are a typical presentation to a military medical department or emergency room. Having a broad differential diagnosis and utilizing a thorough physical exam can assist providers in honing down the list of pathology and in identifying potentially life-threatening causes of cephalgia such as intracranial tumors. In this case, a 27-year-old man presented with progressive headaches along with vision changes for the preceding 2-3 months. On initial physical exam, he was found to have bilateral papilledema using a panoptic ophthalmoscope, confirmed after sending t...
Source: Military Medicine - February 24, 2019 Category: International Medicine & Public Health Tags: Mil Med Source Type: research
GSE124537 Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
Contributors : Philip E Chung ; Eldad ZacksenhausSeries Type : Expression profiling by arrayOrganism : Mus musculusTranscriptome analysis of mRNA samples from Rb/p53-deficient mouse pineoblastomas (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - January 31, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Unedited microneurosurgery of a high-grade pineal parenchymal tumor of intermediate differentiation.
Conclusion: This unedited video offers all detailed aspects that are, as the senior author JH considers, essential for a neurosurgeon when performing an efficient and safe surgery for a high-grade PPTID.
Videolink: http://surgicalneurologyint.com/videogallery/pineal-tumor-2.
PMID: 30603232 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - January 5, 2019 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Therapeutic strategy for pineal parenchymal tumor of intermediate differentiation (PPTID): case report of PPTID with malignant transformation to pineocytoma with leptomeningeal dissemination 6 years after surgery.
Abstract
Pineal parenchymal tumor of intermediate differentiation (PPTID) is rare. The WHO first classified PPTID in 2000 as a pineal parenchymal tumor (PPT) with an intermediate prognosis between pineocytoma (PC) and pineoblastoma (PB). It is considered an intermediate-grade tumor and divided into WHO grade II or III. The number of available reports about PPTID is presently limited, and the appropriate management for this tumor has not yet been determined. The authors report a rare case of PC in a 63-year-old woman who presented with lower-extremity weakness and gait disturbance. A pineal mass lesion was ...
Source: Journal of Neurosurgery - July 20, 2018 Category: Neurosurgery Authors: Bando T, Ueno Y, Shinoda N, Imai Y, Ichikawa K, Kuramoto Y, Kuroyama T, Shimo D, Mikami K, Hori S, Matsumoto M, Hirai O Tags: J Neurosurg Source Type: research
