BCOR expression in paediatric pineoblastoma
Folia Neuropathol. 2023;61(2):121-128. doi: 10.5114/fn.2023.129377.ABSTRACTBCOR is expressed in a new brain tumour entity, i.e. 'CNS tumour with BCOR internal tandem duplication' (HGNET BCOR) but not in several other high grade paediatric brain tumours investigated. Immunohistochemical detection of BCOR expression may therefore serve as a potential diagnostic marker. Nevertheless, in rare paediatric glioma cases recurrent EP300-BCOR fusions were detected, which resulted in strong BCOR immunopositivity. We have therefore examined other, not analysed so far, types of central nervous system (CNS) tumours, pineoblastoma and ge...
Source: Folia Neuropathologica - August 17, 2023 Category: Pathology Authors: Joanna Trubicka Maria Łastowska Agnieszka Karkuci ńska-Więckowska Magdalena Niemira Maria Ejmont Agnieszka Sowi ńska Maciej Pronicki Ewa Matyja Wies ława Grajkowska Source Type: research
BCOR expression in paediatric pineoblastoma
Folia Neuropathol. 2023;61(2):121-128. doi: 10.5114/fn.2023.129377.ABSTRACTBCOR is expressed in a new brain tumour entity, i.e. 'CNS tumour with BCOR internal tandem duplication' (HGNET BCOR) but not in several other high grade paediatric brain tumours investigated. Immunohistochemical detection of BCOR expression may therefore serve as a potential diagnostic marker. Nevertheless, in rare paediatric glioma cases recurrent EP300-BCOR fusions were detected, which resulted in strong BCOR immunopositivity. We have therefore examined other, not analysed so far, types of central nervous system (CNS) tumours, pineoblastoma and ge...
Source: Folia Neuropathologica - August 17, 2023 Category: Neurology Authors: Joanna Trubicka Maria Łastowska Agnieszka Karkuci ńska-Więckowska Magdalena Niemira Maria Ejmont Agnieszka Sowi ńska Maciej Pronicki Ewa Matyja Wies ława Grajkowska Source Type: research
BCOR expression in paediatric pineoblastoma
Folia Neuropathol. 2023;61(2):121-128. doi: 10.5114/fn.2023.129377.ABSTRACTBCOR is expressed in a new brain tumour entity, i.e. 'CNS tumour with BCOR internal tandem duplication' (HGNET BCOR) but not in several other high grade paediatric brain tumours investigated. Immunohistochemical detection of BCOR expression may therefore serve as a potential diagnostic marker. Nevertheless, in rare paediatric glioma cases recurrent EP300-BCOR fusions were detected, which resulted in strong BCOR immunopositivity. We have therefore examined other, not analysed so far, types of central nervous system (CNS) tumours, pineoblastoma and ge...
Source: Folia Neuropathologica - August 17, 2023 Category: Pathology Authors: Joanna Trubicka Maria Łastowska Agnieszka Karkuci ńska-Więckowska Magdalena Niemira Maria Ejmont Agnieszka Sowi ńska Maciej Pronicki Ewa Matyja Wies ława Grajkowska Source Type: research
BCOR expression in paediatric pineoblastoma
Folia Neuropathol. 2023;61(2):121-128. doi: 10.5114/fn.2023.129377.ABSTRACTBCOR is expressed in a new brain tumour entity, i.e. 'CNS tumour with BCOR internal tandem duplication' (HGNET BCOR) but not in several other high grade paediatric brain tumours investigated. Immunohistochemical detection of BCOR expression may therefore serve as a potential diagnostic marker. Nevertheless, in rare paediatric glioma cases recurrent EP300-BCOR fusions were detected, which resulted in strong BCOR immunopositivity. We have therefore examined other, not analysed so far, types of central nervous system (CNS) tumours, pineoblastoma and ge...
Source: Folia Neuropathologica - August 17, 2023 Category: Neurology Authors: Joanna Trubicka Maria Łastowska Agnieszka Karkuci ńska-Więckowska Magdalena Niemira Maria Ejmont Agnieszka Sowi ńska Maciej Pronicki Ewa Matyja Wies ława Grajkowska Source Type: research
BCOR expression in paediatric pineoblastoma
Folia Neuropathol. 2023;61(2):121-128. doi: 10.5114/fn.2023.129377.ABSTRACTBCOR is expressed in a new brain tumour entity, i.e. 'CNS tumour with BCOR internal tandem duplication' (HGNET BCOR) but not in several other high grade paediatric brain tumours investigated. Immunohistochemical detection of BCOR expression may therefore serve as a potential diagnostic marker. Nevertheless, in rare paediatric glioma cases recurrent EP300-BCOR fusions were detected, which resulted in strong BCOR immunopositivity. We have therefore examined other, not analysed so far, types of central nervous system (CNS) tumours, pineoblastoma and ge...
Source: Folia Neuropathologica - August 17, 2023 Category: Pathology Authors: Joanna Trubicka Maria Łastowska Agnieszka Karkuci ńska-Więckowska Magdalena Niemira Maria Ejmont Agnieszka Sowi ńska Maciej Pronicki Ewa Matyja Wies ława Grajkowska Source Type: research
Benign and Malignant Tumors of the Pineal Region
Adv Exp Med Biol. 2023;1405:153-173. doi: 10.1007/978-3-031-23705-8_6.ABSTRACTPineal region tumors fall into five broad categories: benign pineal region tumors, glial tumors, papillary tumors, pineal parenchymal tumors, and germ cell tumors. Genetic and transcriptional studies have identified key chromosomal alterations in germinomas (RUNDC3A, ASAH1, LPL) and in pineocytomas/pineoblastomas (DROSHA/DICER1, RB1). Pineal region tumors generally present with symptoms of hydrocephalus including nausea, vomiting, papilledema, and the classical Parinaud's triad of upgaze paralysis, convergence-retraction nystagmus, and light-near...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Pavan S Upadhyayula Justin A Neira Michael L Miller Jeffrey N Bruce Source Type: research
Non-resective treatment of pineoblastoma in adult: a case report
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - July 13, 2023 Category: Neurology Source Type: research
Cancers, Vol. 15, Pages 3374: Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time
This study demonstrates that EOR less-than-gross total resection, metastatic presentation, adjuvant chemotherapy without radiation, and tumor presentation in children less than three years old are associated with poorer prognosis. Since 2012, the 5-year actuarial OS has improved from 32.8% to 56.1%, which remained significant even after accounting for EOR, age, and adjuvant therapy. Pineoblastoma remains a severe rare disease, but survival outcomes are improving. (Source: Cancers)
Source: Cancers - June 27, 2023 Category: Cancer & Oncology Authors: Khizar R. Nandoliya Nishanth S. Sadagopan Vineeth Thirunavu Ethan J. Houskamp Constantine L. Karras Rahul K. Chaliparambil Nikhil Sriram Pouya Jamshidi David R. Raleigh Rimas V. Lukas Stephen T. Magill Tags: Systematic Review Source Type: research
Pineoblastoma: prognostic factors and survival outcomes in young children
Chin Med J (Engl). 2023 Feb 5;136(3):367-369. doi: 10.1097/CM9.0000000000002063.NO ABSTRACTPMID:36989486 | DOI:10.1097/CM9.0000000000002063 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 29, 2023 Category: General Medicine Authors: Boran Chen Yanjie Zhao Chaoyue Chen Source Type: research
Pineoblastoma: prognostic factors and survival outcomes in young children
Chin Med J (Engl). 2023 Feb 5;136(3):367-369. doi: 10.1097/CM9.0000000000002063.NO ABSTRACTPMID:36989486 | DOI:10.1097/CM9.0000000000002063 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 29, 2023 Category: General Medicine Authors: Boran Chen Yanjie Zhao Chaoyue Chen Source Type: research
Accuracy of apparent diffusion coefficient values for distinguishing between pineal germ cell tumour and pineoblastoma
To differentiate between pineal germ cell tumour and pineoblastoma using apparent diffusion coefficient (ADC) values due to their overlapping imaging findings on magnetic resonance imaging (MRI). (Source: Clinical Radiology)
Source: Clinical Radiology - March 25, 2023 Category: Radiology Authors: T. Panyaping, O. Tritanon, P. Wisetsathon, T. Chansakul, P. Pongpitcha Source Type: research
Accuracy of apparent diffusion coefficient values for distinguishing between pineal germ cell tumor and pineoblastoma
To differentiate between pineal germ cell tumor and pineoblastoma using apparent diffusion coefficient (ADC) values due to their overlapping imaging findings on magnetic resonance imaging (MRI). (Source: Clinical Radiology)
Source: Clinical Radiology - March 25, 2023 Category: Radiology Authors: T. Panyaping., O. Tritanon, P. Wisetsathon., T. Chansakul., P. Pongpitcha. Source Type: research
