Treatment Results for Pineal Region Tumors: Role of Stereotactic Biopsy Plus Adjuvant Therapy vs. Open Resection.
CONCLUSION: The results of the study suggests that although gross total resection is the standard of care in most pineal tumors nowadays, stereotactic biopsy followed by adjuvant therapy may still be a safe and viable option.
PMID: 27161457 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - May 12, 2016 Category: Neurosurgery Authors: Motiei-Langroudi R, Sadeghian H, Soleimani MM, Seddighi AS, Shahzadi S Tags: Turk Neurosurg Source Type: research
MRI-based assessment of the pineal gland in a large population of children aged 0–5 years and comparison with pineoblastoma: part II, the cystic gland
Conclusion
We presented age-adapted normal values for size and morphology of the cystic pineal gland in children aged 0 to 5 years. Analysis of size is helpful in discriminating normal glands from cystic pineal pathologies such as pineoblastoma. We also presented guidelines for the approach of a solid or cystic pineal gland in hereditary retinoblastoma patients. (Source: Neuroradiology)
Source: Neuroradiology - April 28, 2016 Category: Radiology Source Type: research
MRI-based assessment of the pineal gland in a large population of children aged 0–5 years and comparison with pineoblastoma: part I, the solid gland
Conclusion
This study establishes norms for solid pineal gland size in non-retinoblastoma children aged 0–5 years. Knowledge of the size of the normal pineal gland is helpful for detection of pineal gland abnormalities, particularly pineoblastoma. (Source: Neuroradiology)
Source: Neuroradiology - April 28, 2016 Category: Radiology Source Type: research
Clinical Reasoning: Left hemiparesis, ataxia, and optic neuritis in a child previously treated for pineoblastoma
A 13-year-old girl presented acutely with an episode of headache and signs of elevated intracranial pressure from a pineal gland tumor causing obstructive hydrocephalus. After an endoscopic third ventriculostomy and pineal gland biopsy, she was diagnosed with pineoblastoma. She was treated with surgical resection, craniospinal radiotherapy, and subsequent chemotherapy. Brain MRIs were performed every 3 months after surgery and remained stable with no new lesions or signs of residual tumor. However, a follow-up brain MRI performed 6 months after chemotherapy showed some small white matter nonenhancing lesions in supratentor...
Source: Neurology - April 10, 2016 Category: Neurology Authors: Vila-Bedmar, S., Nourbakhsh, B., Anzalone, S., Waubant, E. Tags: MRI, Chemotherapy-tumor, Radiation therapy-tumor, Multiple sclerosis RESIDENT AND FELLOW SECTION Source Type: research
Abstract A52: Investigation of p53 restoration therapy in a mouse model of pineoblastoma
Conclusion: Our data shows that, in a mouse model of Cyclin D1-driven pineoblastoma, restoration of p53 has different effects in premalignant versus invasive pineal tumors, where it may need to be paired with DNA damaging agents for effective tumor suppression. Furthermore, p53 activation may need to be continually sustained in such lesions undergoing senescence. Finally, p53 restoration approaches may be worth exploring in sPNET, where the p53 gene seems to be intact but the pathway inactive in the majority of examined tumors.Citation Format: Mohammad Harajly, Hassan Zalzali, Zafar Nawaz, Raya Saab. Investigation of p53 r...
Source: Cancer Research - April 3, 2016 Category: Cancer & Oncology Authors: Harajly, M., Zalzali, H., Nawaz, Z., Saab, R. Tags: Refractory Malignancies and Difficult to Treat Pediatric Cancers Source Type: research
Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice.
In this study, we generated a tamoxifen-inducible Cre-driver mouse strain for the purpose of widespread and temporal Cre recombination. The new line, named CM32, expresses the GFPneo-fusion gene in a wide variety of tissues before FLP recombination and tamoxifen-inducible Cre after FLP recombination. Using FLP-recombined CM32 mice (CM32Δ mice) and Cre reporter mouse lines, we evaluated the efficiency of Cre recombination with and without tamoxifen administration to adult mice, and found tamoxifen-dependent induction of Cre recombination in a variety of adult tissues. In addition, we demonstrated that conditional activatio...
Source: Experimental Animals - March 2, 2016 Category: Research Tags: Exp Anim Source Type: research
From a Suspicious Cystic Pineal Gland to Pineoblastoma in a Patient with Familial Unilateral Retinoblastoma.
Authors: de Jong MC, Moll AC, Göricke S, van der Valk P, Kors WA, Castelijns JA, de Graaf P
PMID: 24940935 [PubMed - as supplied by publisher] (Source: Ophthalmic Genetics)
Source: Ophthalmic Genetics - February 17, 2016 Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
Upfront Stereotactic Radiosurgery for Pineal Parenchymal Tumors in Adults.
CONCLUSION: SRS is effective and safe for PPTs in adults and can be considered as a useful alternative to surgical resection at upfront setting.
PMID: 26587186 [PubMed - as supplied by publisher] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - November 21, 2015 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
Magnetic resonance imaging based morphologic evaluation of the pineal gland for suspected pineoblastoma in retinoblastoma patients and age-matched controls
The purpose of this study was to evaluate the morphologic magnetic resonance imaging (MRI) characteristics of the pineal gland in retinoblastoma (Rb) patients without and with pineoblastoma in comparison to age-matched controls to improve early identification of pineoblastomas (trilateral retinoblastoma, TRb). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - October 28, 2015 Category: Neurology Authors: Thi Thai Hien Pham, Eberhard Siebert, Patrick Asbach, Gregor Willerding, Katharina Erb-Eigner Source Type: research
Pineal parenchymal tumor of intermediate differentiation.
We report a case of PPTID. A 25-year-old female patient was admitted to hospital with complaints of a headache, nausea, vomiting since 1-year. Computed tomography/magnetic resonance imaging of the brain showed well-defined, mildly enhancing lesion in the region of the pineal gland with areas of calcification. The tumor was excised. After 3 years, she presented with metastasis in thoracic and lumbosacral spinal region. This is a rare event.
PMID: 26549088 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - October 1, 2015 Category: Pathology Authors: Patil M, Karandikar M Tags: Indian J Pathol Microbiol Source Type: research
Supracerebellar infratentorial approach with paramedian expansion for posterior third ventricular and pineal region lesions
The posterior third ventricle can harbor different pathologies including; pineal cysts, cavernomas, pineocytomas, and pineoblastomas [1–3]. The supracerebellar infratentorial approach is used to treat lesions in the posterior third ventricle. This approach allows a direct access to the pineal region, especially when performed with the patient in sitting position, and it provides easier dissection of the arachnoid planes from the tributaries of the deep venous system [4–8]. This approach provide a wide and direct exposure of the posterior third ventricular region, but for those lesions extending laterally into the thala...
Source: Clinical Neurology and Neurosurgery - September 21, 2015 Category: Neurosurgery Authors: Hisham Aboul-Enein, Ahmed Abd El-Aziz Sabry, Ahmed Hafez Farhoud Source Type: research
Clinical, Pathological, and Surgical Outcomes for Adult Pineoblastomas
Conclusions Although this series is small, the data suggest that pineoblastomas in adults have a less aggressive clinical course than in children. (Source: World Neurosurgery)
Source: World Neurosurgery - August 17, 2015 Category: Neurosurgery Source Type: research
Lateral supracerebellar infratentorial approach for microsurgical resection of large midline pineal region tumors: techniques to expand the operative corridor.
Abstract
Pineal region tumors pose certain challenges in regard to their resection: a deep surgical field, associated critical surrounding neurovascular structures, and narrow operative working corridor due to obstruction by the apex of the culmen. The authors describe a lateral supracerebellar infratentorial approach that was successfully used in the treatment of 10 large (> 3 cm) midline pineal region tumors. The patients were placed in a modified lateral decubitus position. A small lateral suboccipital craniotomy exposed the transverse sinus. Tentorial retraction sutures were used to gently rotate an...
Source: Journal of Neurosurgery - August 14, 2015 Category: Neurosurgery Authors: Kulwin C, Matsushima K, Malekpour M, Cohen-Gadol AA Tags: J Neurosurg Source Type: research
Abstract 4934: Mosaic RNase IIIb domain DICER1 mutations in children with multiple primary tumors
We describe four children with multiple primary tumours associated with the DICER1 syndrome. Sanger sequencing of constitutional DNA obtained from peripheral blood lymphocytes and/or saliva revealed no likely deleterious germ-line DICER1 mutations. We subsequently sequenced the region encoding the DICER1 RNase IIIa and RNase IIIb domains in gDNA extracted from the tumor samples, and noted the presence of the same RNase IIIb missense mutation in multiple tumors from each patient (Patient A: c.5437G>C; Patient B: c.5125G>A; Patient C: c.5439G>C; Patient D: c.5425G>A). We performed targeted capture followed by deep sequencing...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: de Kock, L., Rivera Polo, B., Wu, M., Weber, E., Sandoval, C., Hopman, S. M. J., Merks, J. H. M., van Hagen, A., Plager, D. A., Sabbaghian, N., Hamel, N., Bouron-Dal Soglio, D., Priest, J. R., Foulkes, W. D. Tags: Molecular and Cellular Biology Source Type: research
Abstract 1227: Differential efficacy of p53 restoration in induction and maintenance of senescence in premalignant and malignant cells
Restoration of p53 in tumors has been suggested as a possible therapeutic approach, based on preclinical in vivo and in vitro evidence of possible efficacy. However, the relationship between the timing of p53 restoration and its efficacy is still unclear. We now show that restoration of p53 in murine pre-malignant proliferating pineal tumors results in effective cell cycle exit and induction of cellular senescence, while p53 reactivation in established malignant pineal tumors does not impact cell proliferation, unless paired with DNA damaging therapies. This differential effect was not related to levels of p19Arf expressio...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Harajly, M., Zalzali, H., Ghayad, S., Ghamloush, F., Jabbour, M., Basma, H., Tawil, A., Nawaz, Z., Saab, R. H. Tags: Molecular and Cellular Biology Source Type: research
