Phase 1 trial of olaratumab monotherapy and in combination with chemotherapy in pediatric patients with relapsed/refractory solid and central nervous system tumors
Observed pharmacokinetic (PK) data and model predicted PK profiles by weight in pediatric patients treated with olaratumab. The overlay was limited to the first seven cycles where observed data were available to provide meaningful comparison. Overall, there was general agreement between the observed and model predicted serum concentrations as the observed values (colored circle) overlap with the prediction interval (shaded region) from the PK model. The colored circles correspond to each patient in the study. The shaded region represents the 90% prediction interval and the solid line represents the median of predicted conc...
Source: Cancer Medicine - February 22, 2021 Category: Cancer & Oncology Authors: Leo Mascarenhas,
Chitose Ogawa,
Theodore W. Laetsch,
Brenda J. Weigel,
Michael W. Bishop,
Julie Krystal,
Scott C. Borinstein,
Emily K. Slotkin,
Jodi A. Muscal,
Pooja Hingorani,
Donna E. Levy,
Gary Mo,
Ashwin Shahir,
Jennifer Wright,
Steven G Tags: ORIGINAL RESEARCH Source Type: research
Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study
AbstractRecent genomic studies have shed light on the biology and inter-tumoral heterogeneity underlying pineal parenchymal tumors, in particular pineoblastomas (PBs) and pineal parenchymal tumors of intermediate differentiation (PPTIDs). Previous reports, however, had modest sample sizes and lacked the power to integrate molecular and clinical findings. The different proposed molecular group structures also highlighted a need to reach consensus on a robust and relevant classification system. We performed a meta-analysis on 221 patients with molecularly characterized PBs and PPTIDs. DNA methylation profiles were analyzed t...
Source: Acta Neuropathologica - February 22, 2021 Category: Neurology Source Type: research
Characterization of high-grade pineal region lesions: the usefulness of apparent diffusion coefficient volumetric values.
CONCLUSION: The ADCmean value measured on the whole tumor, reflecting tumor proliferative activity, may be a practical and non-invasive marker for predicting tumor histology in high-grade pineal region lesions and might be useful in preoperative assessment.
PMID: 33497274 [PubMed - as supplied by publisher] (Source: Acta Radiologica)
Source: Acta Radiologica - January 26, 2021 Category: Radiology Authors: Calandrelli R, Pilato F, Massimi L, Gessi M, Panfili M, Colosimo C Tags: Acta Radiol Source Type: research
Phase 1 trial of olaratumab monotherapy and in combination with chemotherapy in pediatric patients with relapsed/refractory solid and central nervous system tumors
Observed pharmacokinetic (PK) data and model predicted PK profiles by weight in pediatric patients treated with olaratumab. The overlay was limited to the first seven cycles where observed data were available to provide meaningful comparison. Overall, there was general agreement between the observed and model predicted serum concentrations as the observed values (colored circle) overlap with the prediction interval (shaded region) from the PK model. The colored circles correspond to each patient in the study. The shaded region represents the 90% prediction interval and the solid line represents the median of predicted conc...
Source: Cancer Medicine - January 20, 2021 Category: Cancer & Oncology Authors: Leo Mascarenhas,
Chitose Ogawa,
Theodore W. Laetsch,
Brenda J. Weigel,
Michael W. Bishop,
Julie Krystal,
Scott C. Borinstein,
Emily K. Slotkin,
Jodi A. Muscal,
Pooja Hingorani,
Donna E. Levy,
Gary Mo,
Ashwin Shahir,
Jennifer Wright,
Steven G Tags: ORIGINAL RESEARCH Source Type: research
Histopathological and Immunohistochemical Studies of Pineoblastoma in a Cow
Publication date: January 2021Source: Journal of Comparative Pathology, Volume 182Author(s): Chiaki Mizukami, Mitsutaka Ikezawa, Manabu Yamada (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - December 15, 2020 Category: Pathology Source Type: research
