Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data
CONCLUSION: Given the rarity of this tumor, prospective, collaborative international studies will be vital to improving the long-term survival of these patients.PMID:35664557 | PMC:PMC9154333 | DOI:10.1093/noajnl/vdac056 (Source: Adv Data)
Source: Adv Data - June 6, 2022 Category: Epidemiology Authors: Jordan R Hansford Jie Huang Raelene Endersby Andrew J Dodgshun Bryan K Li Eugene Hwang Sarah Leary Amar Gajjar Katja Von Hoff Olivia Wells Alison Wray Rishi S Kotecha David R Raleigh Schuyler Stoller Sabine Mueller Steven E Schild Pratiti Bandopadhayay Ma Source Type: research
Malignant Pineal Parenchymal Tumors in Adults: A National Cancer Database Analysis
BACKGROUND:
Limited retrospective data exist on malignant pineal parenchymal tumors (PPTs) in adults, and there are no large previous studies that review clinical outcomes across the 3 treatment arms of surgery, radiotherapy, and chemotherapy. As a result, optimal disease management has yet to be defined.
OBJECTIVE:
To evaluate treatment trends and perform survival analysis in adult PPT.
METHODS:
The National Cancer Database was queried for histologically confirmed PPT diagnosed from 2007 to 2016. Univariate and multivariate Cox regressions were used to evaluate the prognostic impact of covariates. Kaplan...
Source: Neurosurgery - May 25, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Tumor Source Type: research
Quantifying intraventricular drug delivery utilizing programmable ventriculoperitoneal shunts as the intraventricular access device
ConclusionsAll patients had successful drug delivery of In-111-DTPA to the ventriculo-thecal space. 73% of the patients had minimal relative (< 12%) peritoneal drug uptake. Though efficacy varies by shunt model, low numbers preclude conclusions regarding model superiority. CSF flow scintigraphy studies assesses drug distribution of In-111-DTPA, informing CSF flow for delivery of intraventricular therapies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 11, 2022 Category: Cancer & Oncology Source Type: research
Epidemiology of pineoblastoma in the United States, 2000-2017
CONCLUSION: PB incidence is highest among children and patients who are Black, and there may be a potential interaction between these factors. Survival is worse among males, young children, and elderly adults, and those who received no surgery. Comprehensive, population-based statistics provide critical information on PB characteristics that could be useful in impacting patient care and prognosis.PMID:35371520 | PMC:PMC8965073 | DOI:10.1093/nop/npac009 (Source: Cancer Control)
Source: Cancer Control - April 4, 2022 Category: Cancer & Oncology Authors: Kaitlyn Greppin Gino Cioffi Kristin A Waite Quinn T Ostrom Daniel Landi Kailey Takaoka Carol Kruchko Jill S Barnholtz-Sloan Source Type: research
Pineoblastoma Without Retinal Tumors in a Patient With a Mosaic Retinoblastoma Pathogenic Variant
This case report describes a diagnosis of pineoblastoma in a child with a retinoblastoma pathogenic variant who presented with increasing head circumference and language and motor delay. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2022 Category: Opthalmology Source Type: research
Clinical characteristics, late effects and outcomes in pineoblastomas in children: a single center experience
CONCLUSIONS: Pineoblastomas are rare but very aggressive tumors; more effective treatment strategies are needed. Survivors should be followed up for late effects such as second malignancies and endocrine deficiencies.PMID:35023643 | DOI:10.24953/turkjped.2021.06.002 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 13, 2022 Category: Pediatrics Authors: Ömer Görgün Ba şak Koç Rejin Kebudi Johannes E Wolff Abut Kebudi Emin Darendeliler Source Type: research
Clinical characteristics, late effects and outcomes in pineoblastomas in children: a single center experience
CONCLUSIONS: Pineoblastomas are rare but very aggressive tumors; more effective treatment strategies are needed. Survivors should be followed up for late effects such as second malignancies and endocrine deficiencies.PMID:35023643 | DOI:10.24953/turkjped.2021.06.002 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 13, 2022 Category: Pediatrics Authors: Ömer Görgün Ba şak Koç Rejin Kebudi Johannes E Wolff Abut Kebudi Emin Darendeliler Source Type: research
Clinical characteristics, late effects and outcomes in pineoblastomas in children: a single center experience
CONCLUSIONS: Pineoblastomas are rare but very aggressive tumors; more effective treatment strategies are needed. Survivors should be followed up for late effects such as second malignancies and endocrine deficiencies.PMID:35023643 | DOI:10.24953/turkjped.2021.06.002 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 13, 2022 Category: Pediatrics Authors: Ömer Görgün Ba şak Koç Rejin Kebudi Johannes E Wolff Abut Kebudi Emin Darendeliler Source Type: research
Clinical characteristics, late effects and outcomes in pineoblastomas in children: a single center experience
CONCLUSIONS: Pineoblastomas are rare but very aggressive tumors; more effective treatment strategies are needed. Survivors should be followed up for late effects such as second malignancies and endocrine deficiencies.PMID:35023643 | DOI:10.24953/turkjped.2021.06.002 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 13, 2022 Category: Pediatrics Authors: Ömer Görgün Ba şak Koç Rejin Kebudi Johannes E Wolff Abut Kebudi Emin Darendeliler Source Type: research
Clinical characteristics, late effects and outcomes in pineoblastomas in children: a single center experience
CONCLUSIONS: Pineoblastomas are rare but very aggressive tumors; more effective treatment strategies are needed. Survivors should be followed up for late effects such as second malignancies and endocrine deficiencies.PMID:35023643 | DOI:10.24953/turkjped.2021.06.002 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 13, 2022 Category: Pediatrics Authors: Ömer Görgün Ba şak Koç Rejin Kebudi Johannes E Wolff Abut Kebudi Emin Darendeliler Source Type: research
Clinical characteristics, late effects and outcomes in pineoblastomas in children: a single center experience
CONCLUSIONS: Pineoblastomas are rare but very aggressive tumors; more effective treatment strategies are needed. Survivors should be followed up for late effects such as second malignancies and endocrine deficiencies.PMID:35023643 | DOI:10.24953/turkjped.2021.06.002 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 13, 2022 Category: Pediatrics Authors: Ömer Görgün Ba şak Koç Rejin Kebudi Johannes E Wolff Abut Kebudi Emin Darendeliler Source Type: research
Clinical characteristics, late effects and outcomes in pineoblastomas in children: a single center experience
CONCLUSIONS: Pineoblastomas are rare but very aggressive tumors; more effective treatment strategies are needed. Survivors should be followed up for late effects such as second malignancies and endocrine deficiencies.PMID:35023643 | DOI:10.24953/turkjped.2021.06.002 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 13, 2022 Category: Pediatrics Authors: Ömer Görgün Ba şak Koç Rejin Kebudi Johannes E Wolff Abut Kebudi Emin Darendeliler Source Type: research
