Abstract LB-172: Novel candidate oncogenic drivers in pineoblastoma
CONCLUSION: Our studies revealed multiple candidate drivers of oncogenesis in PB. We identified novel homozygous deletions in DROSHA, a nuclease involved in microRNA processing. We also identified novel, highly recurrent somatic focal gains involving chromosomal region 1q21, which has been linked to brain growth, autism and schizophrenia, but not previously associated with cancer.Citation Format: Matija Snuderl, Kasthuri Kannan, Olga Aminova, Igor Dolgalev, Adriana Heguy, Arline Faustin, David Zagzag, Sharon L. Gardner, Jeffrey C. Allen, Jeffrey H. Wisoff, David Capper, Volker Hovestadt, Sama Ahsan, Charles Eberhart, Stefa...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Snuderl, M., Kannan, K., Aminova, O., Dolgalev, I., Heguy, A., Faustin, A., Zagzag, D., Gardner, S. L., Allen, J. C., Wisoff, J. H., Capper, D., Hovestadt, V., Ahsan, S., Eberhart, C., Pfister, S. M., Jones, D. T. w., Karajannis, M. A. Tags: Molecular and Cellular Biology Source Type: research
Mb-17 * novel candidate oncogenic drivers in pineoblastoma
(Source: Neuro-Oncology)
Source: Neuro-Oncology - April 23, 2015 Category: Cancer & Oncology Authors: Snuderl, M., Kannan, K., Aminova, O., Dolgalev, I., Heguy, A., Faustin, A., Zagzag, D., Gardner, S., Allen, J., Wisoff, J., Capper, D., Hovestadt, V., Ahsan, S., Eberhart, C., Pfister, S., Jones, D., Karajannis, M. Tags: MEDULLOBLASTOMA Source Type: research
Combined rigid and flexible endoscopy for tumors in the posterior third ventricle.
CONCLUSIONS The authors recommend using a combined rigid-flexible endoscope for endoscopic third ventriculostomy and biopsy to approach posterior third ventricular tumors (behind the massa intermedia). This technique overcomes the limitations of using a rigid endoscope by reaching 2 distant regions.
PMID: 25816082 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 27, 2015 Category: Neurosurgery Authors: Roth J, Constantini S Tags: J Neurosurg Source Type: research
High-dose Chemotherapy With Autologous Stem Cell Rescue in Saudi Children Less Than 3 Years of Age With Embryonal Brain Tumors
High-dose chemotherapy with autologous stem cell rescue (HDC/ASCR) has been used in children under the age of 3 years with embryonal brain tumors to avoid or delay the use of radiation. We reviewed the medical records of 10 Saudi children less than 3 years of age with embryonal brain tumors who underwent HDC/ASCR. All 10 patients underwent surgical resection followed by 3 to 5 cycles of induction chemotherapy and 1 to 3 cycles of HDC/ASCR using carboplatin and thiotepa. Isotretinoin was used as a maintenance therapy in 4 patients. Five patients had medulloblastoma, 3 had atypical teratoid/rhabdoid tumors, 1 had an embryona...
Source: Journal of Pediatric Hematology Oncology - March 23, 2015 Category: Hematology Tags: Original Articles Source Type: research
Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: A report from the Children's Oncology Group
ConclusionsCarboplatin during RT followed by 6 months of non‐intensive chemotherapy is a feasible treatment strategy for patients with sPNET. Aggressive surgical resection should be attempted if feasible. The classification of supratentorial small cell malignancies can be difficult. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - February 19, 2015 Category: Cancer & Oncology Authors: Regina I. Jakacki, Peter C. Burger, Mehmet Kocak, James M. Boyett, Joel Goldwein, Minesh Mehta, Roger J. Packer, Nancy J. Tarbell, Ian F. Pollack Tags: Research Article Source Type: research
Imagery of pineal tumors.
Abstract
Pineal tumors are rare and include a large variety of entities. Germ cell tumors are relatively frequent and often secreting lesions. Pineal parenchymal tumors include pineocytomas, pineal parenchymal tumor of intermediate differentiation, pineoblastomas and papillary tumors of the pineal region. Other lesions including astrocytomas and meningiomas as well as congenital malformations i.e. benign cysts, lipomas, epidermoid and dermoid cysts, which can also arise from the pineal region. Imagery is often non-specific but detailed analysis of the images compared with the hormone profile can narrow the...
Source: Neuro-Chirurgie - February 9, 2015 Category: Neurosurgery Authors: Deiana G, Mottolese C, Hermier M, Louis-Tisserand G, Berthezene Y Tags: Neurochirurgie Source Type: research
Abstract IA03: DICER1: From ontogenesis to oncogenesis
The DICER1 syndrome, also known as the pleuropulmonary blastoma familial tumor dysplasia syndrome (PPB-FTDS) (OMIM #601200), is a recently described entity comprising a number of rare to ultra-rare tumors arising mainly in childhood or adolescence. The most frequent and characteristic disorders are pleuropulmonary blastoma, cystic nephroma and ovarian Sertoli-Leydig cell tumors. Some aspects of the syndrome were identified in the 1970s and 1990s, but discovery in 2009 by Hill et al of heterozygous disease-associated germ-line DICER1 mutations in affected kindred brought the syndrome into focus. Several studies since 2009 h...
Source: Cancer Research - December 12, 2014 Category: Cancer & Oncology Authors: Foulkes, W. D., Wu, M., Kock, L. D., Witkowski, L., Sabbaghian, N., Weber, E., Hamel, N., Priest, J. R. Tags: Oral Presentations Source Type: research
Fractionated Stereotactic Radiation Therapy for Intracranial Malignant Tumor: Preliminary ...
CONCLUSION: FSRT and relocatable stereotactic head frames were well tolerated with minimal transient acute side effects. Subacute or late complications were not observed, because the follow-up period was short. We expect that FSRT might be a good indication for; recurrent disease with previous radiation therapy history, tumors of relatively large volume, lesions adjacent to radiosensitive organs, and as a boost, following conventional radiation therapy. (Source: Cancer Research and Treatment)
Source: Cancer Research and Treatment - November 14, 2014 Category: Cancer & Oncology Tags: Original Article Source Type: research
