Abstract LB-172: Novel candidate oncogenic drivers in pineoblastoma

CONCLUSION: Our studies revealed multiple candidate drivers of oncogenesis in PB. We identified novel homozygous deletions in DROSHA, a nuclease involved in microRNA processing. We also identified novel, highly recurrent somatic focal gains involving chromosomal region 1q21, which has been linked to brain growth, autism and schizophrenia, but not previously associated with cancer.Citation Format: Matija Snuderl, Kasthuri Kannan, Olga Aminova, Igor Dolgalev, Adriana Heguy, Arline Faustin, David Zagzag, Sharon L. Gardner, Jeffrey C. Allen, Jeffrey H. Wisoff, David Capper, Volker Hovestadt, Sama Ahsan, Charles Eberhart, Stefan M. Pfister, David T. w. Jones, Matthias A. Karajannis. Novel candidate oncogenic drivers in pineoblastoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-172. doi:10.1158/1538-7445.AM2015-LB-172

Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Snuderl, M., Kannan, K., Aminova, O., Dolgalev, I., Heguy, A., Faustin, A., Zagzag, D., Gardner, S. L., Allen, J. C., Wisoff, J. H., Capper, D., Hovestadt, V., Ahsan, S., Eberhart, C., Pfister, S. M., Jones, D. T. w., Karajannis, M. A. Tags: Molecular and Cellular Biology Source Type: research