Cytopathological features of pilomyxoid astrocytoma: a case report
This is a case report concerning a Pilomyxoid Astrocytoma (PMA) occuring in a 4 month‐old child in the right temporal/suprasellar region of the brain. It was resected twice, the first time when the tumor was discovered and the second time four years later after recurrence as pilocytic astrocytoma (PA). Cytological features of PMA have been only rarely reported. Furthermore the authors have tried to discuss the evolution of a PMA to a PA illustrating the rare circumstances in which a tumor with a bad prognosis may evolve in a tumor with a better one. (Source: Cytopathology)
Source: Cytopathology - March 27, 2016 Category: Pathology Authors: T. Homma, T. Seki, A. Suzuki, T. Ohta, T. Maebayashi, A. Yoshino, Y. Kusumi, M. Sugitani Tags: Case Report Source Type: research
Contrast Leakage Patterns from Dynamic Susceptibility Contrast Perfusion MRI in the Grading of Primary Pediatric Brain Tumors [PEDIATRICS]
CONCLUSIONS:
There was good interobserver agreement in the classification of DSC perfusion tissue signal-intensity time curves for pediatric brain tumors, particularly for T1-dominant leakage. Among patients with pediatric brain tumors, a T1-dominant leakage pattern is highly specific for a low-grade tumor and demonstrates high sensitivity and specificity for pilocytic or pilomyxoid astrocytomas. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - March 14, 2016 Category: Radiology Authors: Ho, C. Y., Cardinal, J. S., Kamer, A. P., Lin, C., Kralik, S. F. Tags: PEDIATRICS Source Type: research
A Case Series Characterizing Pilomyxoid Astrocytomas in Childhood
Conclusion: Our data suggest that PMAs are hypermetabolic on PET, have elevated PIs and BRAF V600E mutations, and behave aggressively. (Source: Journal of Pediatric Hematology Oncology)
Source: Journal of Pediatric Hematology Oncology - February 19, 2016 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
The clinicopathological features of pituicytoma and the differential diagnosis of sellar glioma
This study explored the clinicopathological features, immunophenotype and differential diagnosis of pituicytoma. We compared 11 cases of pituicytoma and 26 cases of sellar glioma (16 pilocytic astrocytomas, four diffuse astrocytomas, three pilomyxoid astrocytomas, and three third ventricle chordoid gliomas). The 11 pituicytoma cases involved six men and five women (age: 33–65 years). Three of the 11 patients experienced recurrence due to a residual tumor, and one patient underwent three surgeries during a 6‐month period. Imaging findings revealed tumors were in the intrasellar region (four cases), suprasellar region (...
Source: Neuropathology - February 1, 2016 Category: Neurology Authors: Junmei Wang, Zhaoxia Liu, Jiang Du, Yun Cui, Jingyi Fang, Li Xu, Guilin Li Tags: Original Article Source Type: research
Pilomyxoid astrocytoma in the adult cerebellum
Publication date: Available online 14 January 2016 Source:Journal of Clinical Neuroscience Author(s): Annie S. Chen, Iddo Paldor, Alpha E. Tsui, Tanya I. Yuen Pilomyxoid astrocytoma (PMA) is a recently recognised World Health Organization (WHO) Grade II tumour that was previously characterised as a subtype of the WHO Grade I pilocytic astrocytoma (PA). PMA has a histological appearance distinct from PA and a poorer prognosis due to its greater propensity for local recurrence and cerebrospinal dissemination. Although originally considered a paediatric tumour involving mainly the hypothalamic and chiasmatic regio...
Source: Journal of Clinical Neuroscience - January 15, 2016 Category: Neuroscience Source Type: research
Pilomyxoid astrocytomas with rare rosenthal fibers
Abstract
Pilomyxoid astrocytomas (PMAs) were first officially described in 2007. Since then, intermediate pilomyxoid tumors with histopathological features typical of both PMAs and pilocytic astrocytomas (PAs) have been described. However, we found evidence of tumors that are histologically like PMAs but contain rare Rosenthal fibers, which have been reported in PAs but not in PMAs. We retrospectively analyzed four such cases involving a 16-year-old adolescent with a 3-cm recurring suprasellar tumor, an 11-year-old boy with a nonrecurring 3-cm mass in the left cerebellum, an 18-year-old adolescent with a ...
Source: Brain Tumor Pathology - December 15, 2015 Category: Neurology Source Type: research
Pilomyxoid astrocytoma in an adult woman: Case report
We present a 22-year-old patient with a left frontal lobe PMA manifesting with atypical radiographic findings. This is the first reported case of PMA in an adult woman. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - October 9, 2015 Category: Cancer & Oncology Authors: Adam H KibolaShearwood McClelland IIIJoseph HlavinJonathan A Friedman Source Type: research
A clinicopathologic study of diencephalic pediatric low-grade gliomas with BRAF V600 mutation
Abstract
Among brain tumors, the BRAF
V600E mutation is frequently associated with pleomorphic xanthoastrocytomas (PXAs) and gangliogliomas (GGs). This oncogenic mutation is also detected in ~5 % of other pediatric low-grade gliomas (LGGs) including pilocytic astrocytomas (PAs) and diffuse astrocytomas. In the current multi-institutional study of 56 non-PXA/non-GG diencephalic pediatric LGGs, the BRAF
V600 mutation rate is 36 %. V600-mutant tumors demonstrate a predilection for infants and young children (<age 3) and have a higher tendency for mul...
Source: Acta Neuropathologica - August 12, 2015 Category: Neurology Source Type: research
Pilomyxoid Astrocytoma Occurring in the Third Ventricle
We report a case of a 24-year-old man who presented with headache, nausea, and vomiting. Brain CT and MRI revealed a mass occupying only the third ventricle. We performed partial resection. Histological findings, including monophasic growth with a myxoid background, and absence of Rosenthal fibers or eosinophilic granular bodies, as well as the strong positivity for glial fibrillary acidic protein were consistent with PMA. (Source: Journal of Clinical Imaging Science)
Source: Journal of Clinical Imaging Science - July 31, 2015 Category: Radiology Authors: Sanghyeon KimMyongjin KangSunseob ChoiDae Cheol Kim Source Type: research
Magnetic resonance spectroscopy detection of high lipid levels in intraaxial tumors without central necrosis: a characteristic of malignant lymphoma.
CONCLUSIONS Large lipid peaks on (1)H-MRS images of tumors without central necrosis were characteristic of malignant lymphomas. Conversely, small or absent lipid peaks in intraaxial tumors without central necrosis were strongly suggestive of glioma.
PMID: 25748300 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 6, 2015 Category: Neurosurgery Authors: Yamasaki F, Takayasu T, Nosaka R, Amatya VJ, Doskaliyev A, Akiyama Y, Tominaga A, Takeshima Y, Sugiyama K, Kurisu K Tags: J Neurosurg Source Type: research
Incidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma
Conclusion:
Gene fusion is found to be significantly increased in cerebellar pilocytic astrocytoma tumors. Furthermore, 15–9 was found to have a higher incidence among our cohort compared to previous studies. While most of the gene fusion positive pilomyxoid astrocytomas were 15–9, we find the association none significant. (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 3, 2015 Category: Internal Medicine Authors: Hala TahaMaha YehiaMadeha MahmoudMohamed El-BeltagyMyret GhabrielShahenda El-Naggar Source Type: research
Grade II pilocytic astrocytoma in a 3‐month‐old patient with encephalocraniocutaneous lipomatosis (ECCL): Case report and literature review of low grade gliomas in ECCL
We report on the fourth case of LGG in a patient with ECCL; a grade II pilocytic astrocytoma with pilomyxoid features in a 3‐month‐old male, the youngest in literature. © 2015 Wiley Periodicals, Inc. (Source: American Journal of Medical Genetics Part A)
Source: American Journal of Medical Genetics Part A - February 23, 2015 Category: Genetics & Stem Cells Authors: Sarah Bieser, Martin Reis, Miguel Guzman, Karen Gauvain, Samer Elbabaa, Stephen R. Braddock, Mohamed S. Abdel‐Baki Tags: Clinical Report Source Type: research
Differential imaging characteristics and dissemination potential of pilomyxoid astrocytomas versus pilocytic astrocytomas
Conclusion
Some imaging features like enhancement pattern or presence of cysts or hemorrhage may help differentiating these low-grade gliomas. Our results confirm previous scarce data suggesting a higher rate of CSF dissemination in PMAs, even in the youngest patient population. (Source: Neuroradiology)
Source: Neuroradiology - February 9, 2015 Category: Radiology Source Type: research
High accuracy of arterial spin labeling perfusion imaging in differentiation of pilomyxoid from pilocytic astrocytoma
Conclusion
ASL imaging has high accuracy in differentiating PMA from PA. The result of this study may have important applications in prognostication and treatment planning especially in patients with less accessible tumors such as hypothalamic-chiasmatic gliomas. (Source: Neuroradiology)
Source: Neuroradiology - February 9, 2015 Category: Radiology Source Type: research
Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA
Abstract
Pilomyxoid astrocytomas (PMAs) manifest a more aggressive clinical course than pilocytic astrocytomas (PAs). Development of effective therapies demands a better biological understanding of PMA. We first conducted gene expression microarray analysis of 9 PMA and 13 PA from infra‐ and supratentorial sites. Unsupervised hierarchical clustering analysis demonstrated that tumors are grouped according to anatomic site, not diagnosis. Gene expression profiles were then contrasted between eight PMAs and six PAs, all supratentorial/hypothalamic/chiasmal. Clinical outcome of PMAs varied, with four out of four patients wit...
Source: Brain Pathology - January 27, 2015 Category: Neurology Authors: Bette K. Kleinschmidt‐DeMasters, Andrew M. Donson, Hannes Vogel, Nicholas K. Foreman Tags: Research Article Source Type: research
