PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma
Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide-3-kinase (PI3K) activation, contributing to the development of GC insensitivit... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 28, 2020 Category: Internal Medicine Authors: Jing Bi, Zhihui Min, Honglei Yuan, Zhilong Jiang, Ruolin Mao, Tao Zhu, Chunfang Liu, Yuzhen Zeng, Juan Song, Chunling Du and Zhihong Chen Tags: Research Source Type: research

A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia
To explore the genetic correlation between schizophrenia (SCZ) and osteoporosis (OP). (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 27, 2020 Category: Internal Medicine Authors: Li Liu, Yan Wen, Yujie Ning, Ping Li, Bolun Cheng, Shiqiang Cheng, Lu Zhang, Mei Ma, Xin Qi, Chujun Liang, Tielin Yang, Xiangding Chen, Lijun Tan, Hui Shen, Qing Tian, Hong-Wen Deng & hellip; Tags: Research Source Type: research

2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies
An ongoing outbreak of 2019-nCoV pneumonia was first identified in Wuhan, Hubei province, China at the end of 2019. With the spread of the new coronavirus accelerating, person-to-person transmission in family ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 20, 2020 Category: Internal Medicine Authors: Jun She, Jinjun Jiang, Ling Ye, Lijuan Hu, Chunxue Bai and Yuanlin Song Tags: Review Source Type: research

Bone mineral density is negatively correlated with ulcerative colitis: a systematic review and meta-analysis
Newer epidemiological studies suggest that the incidence of ulcerative colitis might be increasing rapidly. Furthermore, osteoporosis in ulcerative colitis patients has gained great attention, but the epidemio... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 18, 2020 Category: Internal Medicine Authors: Tianyu Zhou, Jiaqi Pan, Bin Lai, Li Cen, Wenxi Jiang, Chaohui Yu and Zhe Shen Tags: Review Source Type: research

Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients
The Peroxisome proliferator-activated receptor gamma gene (PPARG), encodes a member of the peroxisome-activated receptor subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) wh... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 17, 2020 Category: Internal Medicine Authors: Howeida Abdullah Mustafa, Afraa Mohamed Suliman Albkrye, Buthiena Mohamed AbdAlla, Mona AbdelRahman Mohammed Khair, Nidal Abdelwahid and Hind Abdelaziz Elnasri Tags: Research Source Type: research

EGFR T790M relative mutation purity predicts osimertinib treatment efficacy in non-small cell lung cancer patients
Despite the impressive anti-tumor activity of osimertinib in epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer (NSCLC) patients, 30 –40% of patients still show limited response. ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 17, 2020 Category: Internal Medicine Authors: Qiufan Zheng, Shaodong Hong, Yan Huang, Hongyun Zhao, Yunpeng Yang, Xue Hou, Yuanyuan Zhao, Yuxiang Ma, Ting Zhou, Yaxiong Zhang, Wenfeng Fang and Li Zhang Tags: Research Source Type: research

The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats
The advent of proprotein convertase subtilisin/kexin type 9 (PCSK9) –inhibiting drugs have provided an effective, but extremely expensive treatment for the management of low density lipoprotein (LDL). Our aim w... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 13, 2020 Category: Internal Medicine Authors: Xinyang Li, Meiniang Wang, Xinhua Zhang, Chuxin Liu, Haitao Xiang, Mi Huang, Yingying Ma, Xiaoyan Gao, Lin Jiang, Xiaopan Liu, Bo Li, Yong Hou, Xiuqing Zhang, Shuang Yang and Naibo Yang Tags: Research Source Type: research

Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer
Accumulating evidence demonstrated immune/inflammation-related implications of basophils in affecting tissue microenvironment that surrounded a tumor, and this study aimed to elucidate the clinical value of se... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 10, 2020 Category: Internal Medicine Authors: Qi Liu, Dakui Luo, Sanjun Cai, Qingguo Li and Xinxiang Li Tags: Research Source Type: research

Embryos derived from donor or patient oocytes are not different for in vitro fertilization outcomes when PGT allows euploid embryo selection: a retrospective study
At our facilities, patients that received embryos using donor oocyte during in vitro fertilization (IVF), usually have had at least one failed attempt to produce at least one euploid embryo with their own oocy... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 7, 2020 Category: Internal Medicine Authors: Elizabeth Schaeffer, Leonardo M. Porchia, Adina Neumann, Almena Luna, Tania Rojas and Esther L ópez-Bayghen Tags: Research Source Type: research

The clinical potential of gene editing as a tool to engineer cell-based therapeutics
The clinical application of ex vivo gene edited cell therapies first began a decade ago with zinc finger nuclease editing of autologous CD4+ T-cells. Editing aimed to disrupt expression of the human immunodeficie... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 7, 2020 Category: Internal Medicine Authors: Candice Ashmore-Harris and Gilbert O. Fruhwirth Tags: Review Source Type: research

Prediction of hepatic metastasis and relapse in colorectal cancers based on concordance analyses with liver fibrosis scores
Liver fibrosis, resulted from several liver diseases, are increasing up to 25% in population in global. It remains undetermined how much impact liver fibrosis have on the development of hepatic metastasis and ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 5, 2020 Category: Internal Medicine Authors: Xiang Hu, Audrey Marietta, Wei-Xing Dai, Ya-Qi Li, Xiao-ji Ma, Long Zhang, San-Jun Cai and Jun-Jie Peng Tags: Research Source Type: research

Unveiling ncRNA regulatory axes in atherosclerosis progression
Completion of the human genome sequencing project highlighted the richness of the cellular RNA world, and opened the door to the discovery of a plethora of short and long non-coding RNAs (the dark transcriptom... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 3, 2020 Category: Internal Medicine Authors: Estanislao Navarro, Adrian Mall én, Josep M. Cruzado, Joan Torras and Miguel Hueso Tags: Review Source Type: research

PI3K inhibitors in thrombosis and cardiovascular disease
Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important intracellular signalling and vesicle trafficking events via the generation of 3-phosphoinositides. Comprising eight core isoforms ac... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 31, 2020 Category: Internal Medicine Authors: Tom N. Durrant and Ingeborg Hers Tags: Review Source Type: research

Personalized CT-based radiomics nomogram preoperative predicting Ki-67 expression in gastrointestinal stromal tumors: a multicenter development and validation cohort
To develop and validate radiomic prediction models using contrast-enhanced computed tomography (CE-CT) to preoperatively predict Ki-67 expression in gastrointestinal stromal tumors (GISTs). (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 31, 2020 Category: Internal Medicine Authors: Qing-Wei Zhang, Yun-Jie Gao, Ran-Ying Zhang, Xiao-Xuan Zhou, Shuang-Li Chen, Yan Zhang, Qiang Liu, Jian-Rong Xu and Zhi-Zheng Ge Tags: Research Source Type: research

Dilemmas about instructions for administering drugs and indications for their use: is there negative effect of pharmaceutical industry?
Instructions for administering some drugs and indications for their use raise certain dilemmas and controversies questioning the appropriateness of the treatment in this way. In this article, some controversie... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 30, 2020 Category: Internal Medicine Authors: Enver Zerem Tags: Perspective Source Type: research

Whole-transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction
Fetal growth restriction (FGR) contributes the primary cause of perinatal mortality and morbidity with impacts on the long-term health. To determine the core gene expression network and gene signatures, which ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 28, 2020 Category: Internal Medicine Authors: Guiying Wang, Jun Yu, Yiwei Yang, Xiaoqin Liu, Xiaobo Zhao, Xudong Guo, Tao Duan, Chenqi Lu and Jiuhong Kang Tags: Research Source Type: research

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression
The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes. Histone a... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 28, 2020 Category: Internal Medicine Authors: Hongyu Zhao, Yunfei Wang, Chao Yang, Junhu Zhou, Lin Wang, Kaikai Yi, Yansheng Li, Qixue wang, Jin Shi, Chunsheng Kang and Liang Zeng Tags: Research Source Type: research

Detection of bladder cancer using urinary cell-free DNA and cellular DNA
The present study sought to identify a panel of DNA markers for noninvasive diagnosis using cell-free DNA (cfDNA) from urine supernatant or cellular DNA from urine sediments of hematuria patients. A panel of 4... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 14, 2020 Category: Internal Medicine Authors: Zhenyu Ou, Kai Li, Ting Yang, Ying Dai, Mohan Chandra, Jun Ning, Yongli Wang, Ran Xu, Tangjie Gao, Yu Xie, Qing He, Yuanwei Li, Qin Lu, Long Wang and Zhuo Song Tags: Research Source Type: research

RANKL/RANK promotes the migration of gastric cancer cells by interacting with EGFR
The incidence and mortality rates of gastric cancer (GC) rank in top five among all malignant tumors. Chemokines and their receptor-signaling pathways reportedly play key roles in the metastasis of malignant t... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 13, 2020 Category: Internal Medicine Authors: Xing Wan, Yongxi Song, Honghong Fang, Ling Xu, Xiaofang Che, Shuo Wang, Xiaomeng Zhang, Lingyun Zhang, Ce Li, Yibo Fan, Kezuo Hou, Zhi Li, Xueqing Wang, Yunpeng Liu and Xiujuan Qu Tags: Research Source Type: research

Systems biology approaches toward autosomal dominant polycystic kidney disease (ADPKD)
In this study, we have re-analyzed a microarray... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 6, 2020 Category: Internal Medicine Authors: Ilnaz Rahimmanesh and Razieh Fatehi Tags: Research Source Type: research

The prognostic value of integration of pretreatment serum amyloid A (SAA) –EBV DNA (S-D) grade in patients with nasopharyngeal carcinoma
Serum amyloid A (SAA) has been associated with the development and prognosis of cancer. The purpose of this study was to evaluate the predictive value of integration of pretreatment SAA –EBV DNA (S-D) grade and... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 6, 2020 Category: Internal Medicine Authors: Jianpei Li, Changchun Lai, Songguo Peng, Hao Chen, Lei Zhou, Yufeng Chen and Shulin Chen Tags: Research Source Type: research

Feasibility study of using high-throughput drug sensitivity testing to target recurrent glioblastoma stem cells for individualized treatment
Despite the well described heterogeneity in glioblastoma (GBM), treatment is standardized, and clinical trials investigate treatment effects at population level. Genomics-driven oncology for stratified treatme... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 30, 2019 Category: Internal Medicine Authors: Erlend Skaga, Evgeny Kulesskiy, Marit Brynjulvsen, Cecilie J. Sandberg, Swapnil Potdar, Iver A. Langmoen, Aki Laakso, Em ília Gaál-Paavola, Markus Perola, Krister Wennerberg and Einar O. Vik-Mo Tags: Research Source Type: research

Mesenchymal stem cell –gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect
Several investigations affirm that, patients with inflammatory bowel disease (IBD) exhibit dysbiosis characterized by restricted biodiversity and imbalanced bacterial composition intertwined with immune dysreg... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 23, 2019 Category: Internal Medicine Authors: Dickson Kofi Wiredu Ocansey, Li Wang, Jingyan Wang, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu and Fei Mao Tags: Review Source Type: research

The dual functional role of MicroRNA-18a (miR-18a) in cancer development
The polycistronic miR-17-92 cluster is instrumental in physiological processes commonly dysregulated in cancer, such as proliferation, the cell cycle, apoptosis, and differentiation. MicroRNA-18a (miR-18a) is ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - December 23, 2019 Category: Internal Medicine Authors: Kexin Shen, Zhe Cao, Ruizhe Zhu, Lei You and Taiping Zhang Tags: Review Source Type: research

Sites of synchronous distant metastases and prognosis in prostate cancer patients with bone metastases at initial diagnosis: a population-based study of 16,643 patients
Bone is a preferential site for prostate cancer (PCa) metastasis. However, sites of synchronous distant metastases in PCa patients with bone metastases at initial diagnosis and their impacts on prognosis are s... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 29, 2019 Category: Internal Medicine Authors: Feng Zhao, Jili Wang, Meiqin Chen, Danni Chen, Sunyi Ye, Xinke Li, Xin Chen, Guoping Ren and Senxiang Yan Tags: Research Source Type: research

Rethinking the combination treatment of fulvestrant and anastrozole for metastatic breast cancer: an integrated reanalysis of aromatase –estrogen receptor axis
Aberrant expression or hyperactivation of aromatase (CYP19A1) –estrogen receptor (ESR) axis is well identified as one of the major causes of breast cancer. Lots of drugs have been developed for targeting CYP19A... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - November 18, 2019 Category: Internal Medicine Authors: Xing Huang Tags: Commentary Source Type: research

Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSC), the most common ovarian carcinoma type, is associated with the highest mortality rate among all gynecological malignancies. As chemoresistance has been demonstrated as ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 29, 2019 Category: Internal Medicine Authors: Xin Qi, Chunjiang Yu, Yi Wang, Yuxin Lin and Bairong Shen Tags: Research Source Type: research

From fiction to science: clinical potentials and regulatory considerations of gene editing
Gene editing technologies such as CRISPR/Cas9 have emerged as an attractive tool not only for scientific research but also for the development of medicinal products. Their ability to induce precise double stra... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 21, 2019 Category: Internal Medicine Authors: Maria Schacker and Diane Seimetz Tags: Review Source Type: research

Debutant iOS app and gene-disease complexities in clinical genomics and precision medicine
The last decade has seen a dramatic increase in the availability of scientific data, where human-related biological databases have grown not only in count but also in volume, posing unprecedented challenges in... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 4, 2019 Category: Internal Medicine Authors: Zeeshan Ahmed, Saman Zeeshan, Ruoyun Xiong and Bruce T. Liang Tags: Short report Source Type: research

Mesenchymal stem cells-derived extracellular vesicles in acute respiratory distress syndrome: a review of current literature and potential future treatment options
Acute respiratory distress syndrome (ARDS) is a life-threatening inflammatory lung condition associated with significant morbidity and mortality. Unfortunately, the current treatment for this disease is mainly... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - September 12, 2019 Category: Internal Medicine Authors: Trushil G. Shah, Dan Predescu and Sanda Predescu Tags: Review Source Type: research

Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
Abnormal regulation and expression of microRNAs (miRNAs) has been documented in various diseases including cancer. The miRNA let-7 (MIRLET7) family controls developmental timing and differentiation. Let-7 loss co... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - August 28, 2019 Category: Internal Medicine Authors: Evgeny Chirshev, Kerby C. Oberg, Yevgeniya J. Ioffe and Juli J. Unternaehrer Tags: Review Source Type: research

New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota
Transformation and growth of tumor cells are associated with profound alterations in neighbouring cells and their environment, together forming the tumor microenvironment (TME). The TME provides a conducive bu... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - August 27, 2019 Category: Internal Medicine Authors: Babita Agrawal Tags: Review Source Type: research

Systemic treatment for lung carcinoids: from bench to bedside
In the huge spectrum of lung neuroendocrine neoplasms, typical and atypical carcinoids should be considered as a separate biological entity from poorly differentiated forms, harboring peculiar molecular altera... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 4, 2019 Category: Internal Medicine Authors: Mariangela Torniai, Laura Scortichini, Francesca Tronconi, Corrado Rubini, Francesca Morgese, Silvia Rinaldi, Paola Mazzanti and Rossana Berardi Tags: Review Source Type: research

Comparison of the effects of amantadine and ondansetron in treatment of fatigue in patients with multiple sclerosis
Multiple sclerosis (MS) is a common neurological disorder with a variety of manifestations including fatigue. Fatigue may interfere with daily work and activities. Different pharmacological and non-pharmacolog... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 1, 2019 Category: Internal Medicine Authors: Mojtaba Khazaei, Ashkan Karevan, Mohammad Taheri and Soudeh Ghafouri-Fard Tags: Research Source Type: research

The role of liver microenvironment in hepatic metastasis
Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delega... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - July 1, 2019 Category: Internal Medicine Authors: Tovah Williamson, Nikhila Sultanpuram and Hossein Sendi Tags: Review Source Type: research

The use of leukocytes ’ secretome to individually target biological therapy in autoimmune arthritis: a case report
Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, clas... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 5, 2019 Category: Internal Medicine Authors: Patrice E. Poubelle, Nathalie Pag é, Marie-Pier Longchamps, Natalia Sampaio Moura, David B. Beck, Ivona Aksentijevich, Philippe A. Tessier and Martin Pelletier Tags: Case report Source Type: research

Circulating monocytes and tumor-associated macrophages express recombined immunoglobulins in glioblastoma patients
Glioblastoma is the most common and malignant brain tumor in adults. Glioblastoma is usually fatal 12 –15 months after diagnosis and the current possibilities in therapy are mostly only palliative. Therefore, n... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - June 3, 2019 Category: Internal Medicine Authors: Svenja Busch, Marina Talamini, Steffen Brenner, Amr Abdulazim, Daniel H änggi, Michael Neumaier, Marcel Seiz-Rosenhagen and Tina Fuchs Tags: Research Source Type: research

The significance of microbiome in personalized medicine
Considering the important role of microbiome, many of current investigations have focused on its beneficial aspects. Although, research explores new dimensions of the impact of microbiome and examines the diff... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 13, 2019 Category: Internal Medicine Authors: Ava Behrouzi, Amir Hossein Nafari and Seyed Davar Siadat Tags: Review Source Type: research

Epigenetics of hepatocellular carcinoma
In recent years, large scale genomics and genome-wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity. Hepatocellular carcinoma, being one of the... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 6, 2019 Category: Internal Medicine Authors: Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow Tags: Review Source Type: research

Genetics in primary care: validating a tool to pre-symptomatically assess common disease risk using an Australian questionnaire on family history
A positive family history for diabetes, cardiovascular diseases or various types of cancer increases the relative risk for these diseases by 2 to 5 times compared to people without a positive family history. T... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 2, 2019 Category: Internal Medicine Authors: Elisa J. F. Houwink, Olga R. Hortensius, Kees van Boven, Annet Sollie and Mattijs E. Numans Tags: Research Source Type: research

Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy
The chemical composition of fucoidan, a kind of sulfated polysaccharide mainly derived from brown seaweed, includes a substantial percentage of l-fucose. Fucoidan has various biological and pharmacological activi... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - May 1, 2019 Category: Internal Medicine Authors: Hsien-Yeh Hsu and Pai-An Hwang Tags: Review Source Type: research

Circulating free DNA concentration as a marker of disease recurrence and metastatic potential in lung cancer
Plasma circulating cell-free (cf) DNA is regarded as a source of tumor DNA. Based on availability of blood tissue for the purposes of early detection of cancer and patients ’ follow-up, several studies have eva... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 18, 2019 Category: Internal Medicine Authors: Hanifeh Mirtavoos-Mahyari, Soudeh Ghafouri-Fard, Adnan Khosravi, Elahe Motevaseli, Zahra Esfahani-Monfared, Sharareh Seifi, Babak Salimi, Vahid Kholghi Oskooei, Mohsen Ghadami and Mohammad Hossein Modarressi Tags: Research Source Type: research

Role of medical and molecular imaging in COPD
Chronic obstructive pulmonary disease (COPD) is expected to climb on the podium of the leading causes of mortality worldwide in the upcoming decade. Clinical diagnosis of COPD has classically relied upon detec... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 15, 2019 Category: Internal Medicine Authors: Lukasz A. Myc, Yun M. Shim, Victor E. Laubach and Julien Dimastromatteo Tags: Review Source Type: research

A non-randomized clinical trial to evaluate the effect of fingolimod on expanded disability status scale score and number of relapses in relapsing-remitting multiple sclerosis patients
Multiple sclerosis (MS) is a chronic disease characterized by demyelination, glial activation and axonal degeneration in the central nervous system. At the present, there is no certain remedy for this disease.... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 8, 2019 Category: Internal Medicine Authors: Mehrdokht Mazdeh, Shahriar Kargar Monhaser, Mohammad Taheri and Soudeh Ghafouri-Fard Tags: Research Source Type: research

Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor microenvironment contains infiltrating immune ce... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - April 1, 2019 Category: Internal Medicine Authors: S. K. Daniel, K. M. Sullivan, K. P. Labadie and V. G. Pillarisetty Tags: Review Source Type: research

The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies
There is growing interest in identifying predictive biomarkers for inhibitors of programmed cell death protein 1 receptor (PD-1), programmed death ligand 1 (PD-L1), and cytotoxic T-lymphocyte associated protei... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 18, 2019 Category: Internal Medicine Authors: Jun Gong, Alexander Chehrazi-Raffle, Veronica Placencio-Hickok, Michelle Guan, Andrew Hendifar and Ravi Salgia Tags: Review Source Type: research

Impact of fatty acid binding protein 5-deficiency on COPD exacerbations and cigarette smoke-induced inflammatory response to bacterial infection
Although cigarette smoking (CS) is by far the most important risk factor of chronic obstructive pulmonary disease (COPD), repeated and sustained infections are clearly linked to disease pathogenesis and are re... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 15, 2019 Category: Internal Medicine Authors: Deviyani M. Rao, Della T. Phan, Michelle J. Choo, Michael R. Weaver, Rebecca E. Oberley-Deegan, Russell P. Bowler and Fabienne Gally Tags: Research Source Type: research

Cell membrane protein functionalization of nanoparticles as a new tumor-targeting strategy
Nanoparticles have seen considerable popularity as effective tools for drug delivery. However, non-specific targeting continues to remain a challenge. Recently, biomimetic nanoparticles have emerged as an inno... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 15, 2019 Category: Internal Medicine Authors: Anna Pasto, Federica Giordano, Michael Evangelopoulos, Alberto Amadori and Ennio Tasciotti Tags: Review Source Type: research

Comparison of administration of clopidogrel with aspirin versus aspirin alone in prevention of secondary stroke after transient ischemic attack
Patients with transient ischemic attack (TIA) or minor stroke are at risk of strokes. One of the precautionary measures to reduce risk of stroke in these patients is administration of antiplatelet drugs. (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - March 4, 2019 Category: Internal Medicine Authors: Mojtaba Khazaei, Fateme Ghasemian, Mehrdokht Mazdeh, Mohammad Taheri and Soudeh Ghafouri-Fard Tags: Research Source Type: research

Expression of Concern to: Clinical study of Gene-Eden-VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases
The Editor of this journal has published this Expression of Concern to alert readers that, following publication of the article [1], it came to light that there were undeclared competing interests that have a ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 6, 2019 Category: Internal Medicine Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian Tags: Correction Source Type: research