The clinicopathological features of pituicytoma and the differential diagnosis of sellar glioma

This study explored the clinicopathological features, immunophenotype and differential diagnosis of pituicytoma. We compared 11 cases of pituicytoma and 26 cases of sellar glioma (16 pilocytic astrocytomas, four diffuse astrocytomas, three pilomyxoid astrocytomas, and three third ventricle chordoid gliomas). The 11 pituicytoma cases involved six men and five women (age: 33–65 years). Three of the 11 patients experienced recurrence due to a residual tumor, and one patient underwent three surgeries during a 6‐month period. Imaging findings revealed tumors were in the intrasellar region (four cases), suprasellar region (four cases) and intra‐suprasellar regions (three cases). The tumor diameters were 1.3–3.8 cm, and the preoperative diagnoses were pituitary adenoma, craniopharyngioma and meningioma. The tumors were solid and contained spindle or slightly chubby cells that were densely arranged with visible cleft‐like or expanded sinusoid structures. The cells had vague boundaries, circular nuclei, fine chromatin, and a small nucleolus. Immunohistochemical staining of the pituicytomas revealed positive expression of thyroid transcription factor‐1 (TTF‐1) and S‐100 protein (S‐100), positive focal expression of glial GFAP;(five of 11 cases), and negative oligodendrocyte transcription factor 2 (Olig2), CD34 and neurofilament expression. The Ki67 index was 6% in one case and 1–2% in the other cases. Unlike pituicytoma, most sellar glioma cases exhibited GFAP and...
Source: Neuropathology - Category: Neurology Authors: Tags: Original Article Source Type: research