Histological features in pediatric central nervous system tumors with FGFR alterations
CONCLUSIONS: Pediatric FGFR-fused CNS tumors demonstrate histologic features similar to their adult counterparts but also exhibit significant morphologic variability. As such, this histologic variability prevents the prediction of FGFR fusion and necessitates molecular testing for the identification of this alteration.PMID:33480239 | DOI:10.5114/fn.2020.102437 (Source: Folia Neuropathologica)
Source: Folia Neuropathologica - January 22, 2021 Category: Pathology Authors: Ahmed Gilani Kurtis Davies Bette Kleinschmidt-DeMasters Source Type: research
Histological features in pediatric central nervous system tumors with FGFR alterations
CONCLUSIONS: Pediatric FGFR-fused CNS tumors demonstrate histologic features similar to their adult counterparts but also exhibit significant morphologic variability. As such, this histologic variability prevents the prediction of FGFR fusion and necessitates molecular testing for the identification of this alteration.PMID:33480239 | DOI:10.5114/fn.2020.102437 (Source: Folia Neuropathologica)
Source: Folia Neuropathologica - January 22, 2021 Category: Pathology Authors: Ahmed Gilani Kurtis Davies Bette Kleinschmidt-DeMasters Source Type: research
Histological features in pediatric central nervous system tumors with FGFR alterations
CONCLUSIONS: Pediatric FGFR-fused CNS tumors demonstrate histologic features similar to their adult counterparts but also exhibit significant morphologic variability. As such, this histologic variability prevents the prediction of FGFR fusion and necessitates molecular testing for the identification of this alteration.PMID:33480239 | DOI:10.5114/fn.2020.102437 (Source: Folia Neuropathologica)
Source: Folia Neuropathologica - January 22, 2021 Category: Pathology Authors: Ahmed Gilani Kurtis Davies Bette Kleinschmidt-DeMasters Source Type: research
Histological features in pediatric central nervous system tumors with FGFR alterations
CONCLUSIONS: Pediatric FGFR-fused CNS tumors demonstrate histologic features similar to their adult counterparts but also exhibit significant morphologic variability. As such, this histologic variability prevents the prediction of FGFR fusion and necessitates molecular testing for the identification of this alteration.PMID:33480239 | DOI:10.5114/fn.2020.102437 (Source: Folia Neuropathologica)
Source: Folia Neuropathologica - January 22, 2021 Category: Pathology Authors: Ahmed Gilani Kurtis Davies Bette Kleinschmidt-DeMasters Source Type: research
Histological features in pediatric central nervous system tumors with FGFR alterations
CONCLUSIONS: Pediatric FGFR-fused CNS tumors demonstrate histologic features similar to their adult counterparts but also exhibit significant morphologic variability. As such, this histologic variability prevents the prediction of FGFR fusion and necessitates molecular testing for the identification of this alteration.PMID:33480239 | DOI:10.5114/fn.2020.102437 (Source: Folia Neuropathologica)
Source: Folia Neuropathologica - January 22, 2021 Category: Pathology Authors: Ahmed Gilani Kurtis Davies Bette Kleinschmidt-DeMasters Source Type: research
Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma
ConclusionSimilar variant allele frequencies ofFGFR1 p.K656E andFGFR1 p.V561M mutations in our patient's tumor suggest that these mutations may have occurred at similar time points. Use of FGFR inhibitors in addition to STAT3 or PI3K/mTOR inhibition may prove a useful strategy in targeting our patient's pilomyxoid astrocytoma. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - January 15, 2021 Category: Genetics & Stem Cells Authors: Elena I. Fomchenko,
Benjamin C. Reeves,
William Sullivan,
Asher M. Marks,
Anita Huttner,
Kristopher T. Kahle,
E. Zeynep Erson ‐Omay Tags: CLINICAL REPORT Source Type: research
Frequent Clinical and Radiological Progression of Optic Pathway/Hypothalamic Pilocytic Astrocytoma in Adolescents and Young Adults.
In conclusion, histological diagnoses of OHG before and in AYA were pilocytic astrocytoma or pilomyxoid astrocytoma. Both pediatric and AYA-onset OHPA demonstrate high incidences of tumor progression and visual dysfunctions in AYA, so that long-term follow up is essential after the completion of treatment for pediatric and AYA-onset OHPA. The optimal timing of debulking surgery and radiation therapy should be established to achieve the long-term tumor control and to preserve the visual function.
PMID: 32404575 [PubMed - as supplied by publisher] (Source: Neurologia Medico-Chirurgica)
Source: Neurologia Medico-Chirurgica - May 15, 2020 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Association of the FGFR1 mutation with spontaneous hemorrhage in low-grade gliomas in pediatric and young adult patients.
CONCLUSIONS: Although the mechanism remains unclear, the FGFR1 mutation is associated with spontaneous hemorrhage in pediatric and young adult LGG.
PMID: 32059187 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - February 13, 2020 Category: Neurosurgery Authors: Ishi Y, Yamaguchi S, Hatanaka KC, Okamoto M, Motegi H, Kobayashi H, Terasaka S, Houkin K Tags: J Neurosurg Source Type: research
Thoracolumbar pilomyxoid astrocytoma concomitant with spinal scoliosis: A case report and literature review.
Conclusion: We recommend the early performance of a thoracic MR in children with idiopathic scoliosis presenting with the onset of a significant spastic paraparesis.
PMID: 31893136 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - January 2, 2020 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Differentiation of pilocytic and pilomyxoid astrocytomas using dynamic susceptibility contrast perfusion and diffusion weighted imaging
ConclusionPMA has a significantly higher rCBV than PA in the infratentorial space. DSC perfusion and diffusion MR imaging may be helpful to distinguish between the two tumor types in this location. (Source: Neuroradiology)
Source: Neuroradiology - October 31, 2019 Category: Radiology Source Type: research
Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors
ConclusionWe demonstrate a strong association between intraoperative observations and spectrometric measurements of PPIX fluorescence in tumor tissue. As in former studies, fluorescence signal was more commonly observed in malignant glial tumors. Further prospective controlled trials should be conducted to investigate the feasibility of 5-ALA-guided resection of pediatric brain tumors. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - August 20, 2019 Category: Neurosurgery Source Type: research
Pilomyxoid astrocytomas: a short review
AbstractPilomyxoid astrocytoma is a variant of pilocytic astrocytoma and the clinical, histological and molecular data point to a very close relationship as well as a more aggressive biological behavior for the former. WHO 2016 classification does not provide a specific grade for these neoplasms, but there is sufficient evidence in the literature that pilomyxoid astrocytoma has slightly worse prognosis than typical pilocytic astrocytoma. There is increasing evidence that in addition to the MAPK pathway alterations, pilomyxoid astrocytomas harbor genetic alterations that distinguish them from typical pilocytic astrocytoma (...
Source: Brain Tumor Pathology - April 2, 2019 Category: Neurology Source Type: research
22. Clinical utility of integrated genomic profiling in pediatric brain tumor
Brain tumors are the most common solid tumor among children under 15, representing 20% of childhood cancers. Prognosis and therapeutic options vary dramatically based on histologic and molecular profiles. We have studied 222 brain tumors using the CHOP Comprehensive Solid Tumor Panel, which interrogates 238 cancer genes and 110 fusion partners. The most common tumors are pilocytic/pilomyxoid astrocytoma (67), medulloblastoma (23) and diffuse midline glioma (17). Clinically significant genomic alterations were identified in 93% of patients. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - July 11, 2018 Category: Genetics & Stem Cells Authors: Fumin Lin, Fengqi Chang, Lea Surrey, Gozde Akgumus, Daniel Gallo, Kajia Cao, Mariarita Santi, Angela Waanders, Marilyn Li Source Type: research
Endovascular glue embolization of a radiation-induced lenticulostriate artery pseudoaneurysm in a pediatric patient with optic pathway glioma: Case report and review of literature.
We present a young patient with a radiation-induced intracranial pseudoaneurysm arising from the lenticulostriate branch of the left middle cerebral artery (MCA); this developed 1 year 4 months after 59.4 Gy of focused radiation to the suprasellar pilomyxoid astrocytoma. The patient successfully underwent endovascular glue embolization of the aneurysm and occlusion of the lenticulostriate artery after unsuccessful trapping of the aneurysm and occlusion of the parent artery using coils. She developed transient hemiparesis of the right side following the procedure, which was managed conservatively. We performed a complete ...
Source: Interventional Neuroradiology - June 2, 2018 Category: Radiology Tags: Interv Neuroradiol Source Type: research
