22. Clinical utility of integrated genomic profiling in pediatric brain tumor

Brain tumors are the most common solid tumor among children under 15, representing 20% of childhood cancers. Prognosis and therapeutic options vary dramatically based on histologic and molecular profiles. We have studied 222 brain tumors using the CHOP Comprehensive Solid Tumor Panel, which interrogates 238 cancer genes and 110 fusion partners. The most common tumors are pilocytic/pilomyxoid astrocytoma (67), medulloblastoma (23) and diffuse midline glioma (17). Clinically significant genomic alterations were identified in 93% of patients.

Source: Cancer Genetics and Cytogenetics - July 11, 2018 Category: Genetics & Stem Cells Authors: Fumin Lin, Fengqi Chang, Lea Surrey, Gozde Akgumus, Daniel Gallo, Kajia Cao, Mariarita Santi, Angela Waanders, Marilyn Li Source Type: research