Corrigendum: Blocking soluble Fas Ligand ameliorates pemphigus: PC111 efficacy in ex-vivo human pemphigus models
(Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 23, 2024 Category: Allergy & Immunology Source Type: research
The autoimmune IgG subclass response defines the IgG deposition pattern in pemphigus patient skin
Pemphigus is an autoimmune blistering disease that is caused by autoantibodies to the extracellular domains of desmoglein (Dsg) 1 and/or 3 (Egami et al., 2020). Desmogleins are cadherin molecules that interconnect two half-desmosomes, ensuring stable binding between neighboring keratinocytes. When bound to desmoglein, these autoantibodies deposit in the stratified epithelial layers of skin and mucosa. Indirect immunofluorescence of healthy skin or mucosa sections shows a smooth and even desmoglein staining around cells, while direct immunofluorescence of the patient lesional skin shows granular IgG deposits to a greater or...
Source: Journal of Investigative Dermatology - January 23, 2024 Category: Dermatology Authors: Hendri H. Pas, Marije van der Molen, Laura van Nijen-Vos, Miranda Nijenhuis, Jeroen Bremer Tags: Letters to the Editor Source Type: research
The efficacy and safety of low-dose rituximab in the treatment of pemphigus vulgaris: a cohort study
CONCLUSIONS: This study indicated that low-dose RTX may be a beneficial and secure therapy option for patients with moderate to severe PV.PMID:38247364 | DOI:10.1080/09546634.2024.2302071 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 22, 2024 Category: Dermatology Authors: Xingli Zhou Tongying Zhan Xiaoxi Xu Tianjiao Lan Hongxiang Hu Yuxi Zhou Dengmei Xia Jinqiu Wang Yiyi Wang Yue Xiao Wei Li Source Type: research
Giant Ulcer with Necrosis on Right Vulva, Groin, and Thigh-- A Case of Necrotizing Fasciitis Associated with Erythematous Pemphigus
We report a case of a 72-year female with erythematous pemphigus who developed erythema, swelling and ulceration on right vulva, groin, and thigh. The early clinical manifestations of the patient were nonspecific and easily misdiagnosed as cellulitis. However, upon the occurrence of ulceration and necrosis, deep fungal infection, pyoderma gangrenosum or lymphoproliferative disorders were considered. The pathology suggested IgG4-related diseases, plasmacytoma et al. But at last, surgical exploration and postoperative pathology confirmed the diagnosis of necrotizing fasciitis. The patient recovered after multiple aggressive ...
Source: Clinical, Cosmetic and Investigational Dermatology - January 18, 2024 Category: Dermatology Authors: Miao Wan Xiangrong Xu Xiaojiao Zhao Xia You Guiying Zhang Hai Long Ping He Jian Long Jianjian Zhu Source Type: research
Inflammatory conditions of the oral mucosa
Inflammatory mucocutaneous conditions that affect the oral cavity are wide ranging with overlapping clinical and histological features. Clinically these can present with a range of appearances including lace to plaque like patches to erosive and ulcerative conditions. Many of these conditions are associated with systemic affects including gastrointestinal, ocular and dermatological. Early recognition is essential to ensure optimal patient care and appropriate referral to other specialists. This review will concentrate on lichenoid mucositis including lichen planus and erythema multiforme, the vesiculo-bullous conditions pe...
Source: Diagnostic Histopathology - January 12, 2024 Category: Pathology Authors: Philip A Atkin, Syed A Khurram, Adam V Jones Tags: Mini-symposium: head and neck pathology Source Type: research
Novel Arena of Nanocosmetics: Applications and their Remarkable Contribution in the Management of Dermal Disorders, Topical Delivery, Future Trends and Challenges
Curr Pharm Des. 2024 Jan 10. doi: 10.2174/0113816128288516231228101024. Online ahead of print.ABSTRACTNanocosmetics have attracted a considerable audience towards natural care due to their low cost, target-specific delivery, and reduced toxicity compared to chemical-based cosmetics. Nanofomulations, including nanoemulsions, nanotubes, and polymeric carriers, have become next-generation products explored for the multifaced applications of nanotechnology in skin care. The rise in the cosmetic industry demands innovative and personalized products designed using nanocarriers for better targeting and improving patient complianc...
Source: Current Pharmaceutical Design - January 11, 2024 Category: Drugs & Pharmacology Authors: Ashima Ahuja Meenakshi Bajpai Source Type: research
Comparison of gut microbiota dysbiosis between pemphigus vulgaris and bullous pemphigoid
CONCLUSIONS: Our study suggests that the composition of gut microbiota is specific in different bullous diseases and the role of gut microbiota differs. Gut microbiota could help distinguish BP and PV, and might play a role in the pathogenesis of different bullous diseases.PMID:38185033 | DOI:10.1016/j.intimp.2023.111470 (Source: International Immunopharmacology)
Source: International Immunopharmacology - January 7, 2024 Category: Allergy & Immunology Authors: Ziying Han Yue Fan Qingyang Wu Feng Guo Sizhe Li Xiaomin Hu Ya-Gang Zuo Source Type: research
Development of novel treatment for pemphigus and confirmation of its efficacy: a randomized controlled trial of protein A-immunoadsorption therapy
Br J Dermatol. 2024 Jan 4:ljae008. doi: 10.1093/bjd/ljae008. Online ahead of print.NO ABSTRACTPMID:38174665 | DOI:10.1093/bjd/ljae008 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 4, 2024 Category: Dermatology Authors: Takashi Hashimoto Jun Yamagami Source Type: research
Development of novel treatment for pemphigus and confirmation of its efficacy: a randomized controlled trial of protein A-immunoadsorption therapy
Br J Dermatol. 2024 Jan 4:ljae008. doi: 10.1093/bjd/ljae008. Online ahead of print.NO ABSTRACTPMID:38174665 | DOI:10.1093/bjd/ljae008 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 4, 2024 Category: Dermatology Authors: Takashi Hashimoto Jun Yamagami Source Type: research
Eponyms and Clinical Entities from the Land of Israel
Seven eponyms havd been pioneered by dermatologists in Israel: Brenner's sign, Chanarin-Dorfman syndrome, granulated sweetener packet sign, isopathic the phenomenon of Sagher, lanolin paradox, Nakar-Ingber disease, and Wolf's isotopic response. In addition, three id reactions described by Israeli dermatologists are listed: leishmanid, pediculid and scabid. There is also the acronym PEMPHIGUS, which stands for the causative reasons for pemphigus. We celebrate these eponyms and clinical entities, which reflect the impressive progress made by dermatologists in Israel during the past century, which has helped to build an acade...
Source: Clinics in Dermatology - December 29, 2023 Category: Dermatology Authors: Leonard J. Hoenig, Sarah Brenner, Ronni Wolf, Arieh Ingber, Jane M. Grant-Kels, Dan Lipsker, Lawrence Charles Parish Tags: Reflections on Dermatology: Past, Present, and Future Source Type: research
C3d Immunohistochemical Staining on Paraffin-Embedded Tissue for Diagnosis of Pemphigus
CONCLUSIONS.—: Our study indicated that C3d-IHC results for paraffin-fixed tissues were not significantly different from DIF results for the diagnosis of pemphigus. The C3d-IHC assay has the potential for routine diagnosis of pemphigus, especially in the absence of fresh-frozen tissue.PMID:38149406 | DOI:10.5858/arpa.2023-0274-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - December 27, 2023 Category: Laboratory Medicine Authors: Nanhui Wu Yijie Cai Fei Wu Yulin Liang Shuyi Liu Pengfei Zhang Yeqiang Liu Source Type: research
Potential Indications of Dupilumab in Th-2 Inflammatory Disease
Rev Recent Clin Trials. 2023 Dec 20. doi: 10.2174/0115748871263396231121060901. Online ahead of print.ABSTRACTDupilumab is a fully humanized IgG4 monoclonal antibody, inhibiting IL-4 and IL-13 signaling, which are the main cytokines involved in type 2 inflammatory diseases. Its introduction was a breakthrough in the treatment of moderate-to-severe atopic dermatitis, but it is also used in other inflammatory diseases, including asthma, eosinophilic esophagitis and chronic rhinosinusitis with nasal polyposis. Recent advances in the understanding of inflammatory pathways have revealed that Th2-type inflammation is involved in...
Source: Reviews on Recent Clinical Trials - December 23, 2023 Category: Cancer & Oncology Authors: Proietti Ilaria Skroza Nevena Tolino Ersilia Bernardini Nicoletta Federica Trovato Marco Di Fraia Dybala Agniezska Potenza Concetta Source Type: research
Potential Indications of Dupilumab in Th-2 Inflammatory Disease
Rev Recent Clin Trials. 2023 Dec 20. doi: 10.2174/0115748871263396231121060901. Online ahead of print.ABSTRACTDupilumab is a fully humanized IgG4 monoclonal antibody, inhibiting IL-4 and IL-13 signaling, which are the main cytokines involved in type 2 inflammatory diseases. Its introduction was a breakthrough in the treatment of moderate-to-severe atopic dermatitis, but it is also used in other inflammatory diseases, including asthma, eosinophilic esophagitis and chronic rhinosinusitis with nasal polyposis. Recent advances in the understanding of inflammatory pathways have revealed that Th2-type inflammation is involved in...
Source: Reviews on Recent Clinical Trials - December 23, 2023 Category: Cancer & Oncology Authors: Proietti Ilaria Skroza Nevena Tolino Ersilia Bernardini Nicoletta Federica Trovato Marco Di Fraia Dybala Agniezska Potenza Concetta Source Type: research
Potential Indications of Dupilumab in Th-2 Inflammatory Disease
Rev Recent Clin Trials. 2023 Dec 20. doi: 10.2174/0115748871263396231121060901. Online ahead of print.ABSTRACTDupilumab is a fully humanized IgG4 monoclonal antibody, inhibiting IL-4 and IL-13 signaling, which are the main cytokines involved in type 2 inflammatory diseases. Its introduction was a breakthrough in the treatment of moderate-to-severe atopic dermatitis, but it is also used in other inflammatory diseases, including asthma, eosinophilic esophagitis and chronic rhinosinusitis with nasal polyposis. Recent advances in the understanding of inflammatory pathways have revealed that Th2-type inflammation is involved in...
Source: Reviews on Recent Clinical Trials - December 23, 2023 Category: Cancer & Oncology Authors: Proietti Ilaria Skroza Nevena Tolino Ersilia Bernardini Nicoletta Federica Trovato Marco Di Fraia Dybala Agniezska Potenza Concetta Source Type: research
Potential Indications of Dupilumab in Th-2 Inflammatory Disease
Rev Recent Clin Trials. 2023 Dec 20. doi: 10.2174/0115748871263396231121060901. Online ahead of print.ABSTRACTDupilumab is a fully humanized IgG4 monoclonal antibody, inhibiting IL-4 and IL-13 signaling, which are the main cytokines involved in type 2 inflammatory diseases. Its introduction was a breakthrough in the treatment of moderate-to-severe atopic dermatitis, but it is also used in other inflammatory diseases, including asthma, eosinophilic esophagitis and chronic rhinosinusitis with nasal polyposis. Recent advances in the understanding of inflammatory pathways have revealed that Th2-type inflammation is involved in...
Source: Reviews on Recent Clinical Trials - December 23, 2023 Category: Cancer & Oncology Authors: Proietti Ilaria Skroza Nevena Tolino Ersilia Bernardini Nicoletta Federica Trovato Marco Di Fraia Dybala Agniezska Potenza Concetta Source Type: research
