Targeting Pro-Inflammatory Cytokine IL-17 to Slow Skin Aging
Researchers here report that a few cell types in aged skin begin to generate large amounts of IL-17, an inflammatory signal molecule. While the obvious suspect here is cellular senescence, as we know that senescent cells accumulate with age and energetically secrete pro-inflammatory signal molecules, this data suggests that this may not be the case, at least for this particular signal molecule in this particular tissue. The researchers show that blocking IL-17 slows the manifestations of skin aging. The challenge in this sort of approach is that inflammatory signal molecules are needed for the normal immune response to fun...
Source: Fight Aging! - June 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Chimeric Antigen Receptor Strategies can be Used to Target and Destroy Specific Classes of Unwanted Immune Cell
The work noted here is targeted at curing autoimmune conditions by removing the misconfigured immune cells that attack important infrastructure in tissues. This is good news for all autoimmunity in which the relevant biochemistry is fairly well understood - where the target immune cells can be well described in terms of their distinctive surface chemistry. However this is also very good news for the prospects of rejuvenating the aged adaptive immune system, wherein much of the problem is that the available capacity for immune cells is used up by an excess of cells uselessly specific to persistent viruses such as cytomegalo...
Source: Fight Aging! - July 1, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Funtabulously Frivolous Friday Five 132
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old-fashioned medical trivia…introducing Funtabulously Frivolous Friday Five 132
Question 1
What is the Asboe-Hansen sign, seen in toxic epidermal necrolysis (TEN)?
+ Reveal the Funtabulous Answer
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The Asboe-Hansen sign (also known as “indirect Nikolsky sign”or “Nikolsky II sign”) refers to the extension of a blister to adjacent unblistered skin when press...
Source: Life in the Fast Lane - January 22, 2016 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five Asboe-Hansen Sign FFFF flu le fort plasters Pterygium Source Type: blogs
Why NOT follow the Wheat Belly approach?
A frequently asked question around this neighborhood: “I (or my friend/husband/wife/cousin etc.) have ______________ (insert condition). Can wheat elimination help me?”
We know for certain that a wide range of human health conditions recede or disappear with wheat elimination, from autoimmune diseases, to common skin rashes like eczema and seborrhea, to metabolic disorders like type 2 diabetes and obesity. We know this from published clinical data, confirmed with the overwhelming cumulative experience generated through the Wheat Belly experience.
But we don’t have data nor experience for many uncommon con...
Source: Wheat Belly Blog - July 11, 2014 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle acid reflux autoimmune Inflammation migraine Source Type: blogs
Paget's disease if Nipple- Review
Clinical:Approximately 1% –3% of women with adenocarcinoma of the breast have Paget disease. Clinically-Paget disease has common dermatitis-like appearance, as originally described in 1874, when Sir James Paget recorded that such lesions may resemble “ordinary chronic eczema” or present as nipple erosion or ulceration. Paget disease often has a deceptively banal clinical morphology but should lead the list of differential diagnoses when evaluating unilateral lesions of the nipple–areola complex in adults.Paget disease presenting with nipple erosion. Most women with the histopathologic finding of Paget disease ...
Source: Oncopathology - June 28, 2013 Category: Cancer & Oncology Tags: a common misdiagnosis. breast Breast Biopsy Procedure Breast Carcinoma vs. Pulmonary Adenocarcinoma Source Type: blogs
Paget's disease if Nipple- Review
Clinical:
Approximately 1%–3% of women with adenocarcinoma of the
breast have Paget disease. Clinically-Paget disease has common dermatitis-like appearance,
as originally described in 1874, when Sir James Paget recorded that such
lesions may resemble “ordinary chronic eczema” or present as nipple erosion or
ulceration. Paget disease often has a deceptively banal clinical morphology but
should lead the list of differential diagnoses when evaluating unilateral
lesions of the nipple–areola complex in adults.
Paget disease presenting with nipple erosion.
Most women with the histopathologic finding o...
Source: Oncopathology - June 28, 2013 Category: Pathologists Tags: Breast Biopsy Procedure Breast Carcinoma vs. Pulmonary Adenocarcinoma a common misdiagnosis. Source Type: blogs
