Paget's disease if Nipple- Review
Clinical:
Approximately 1%–3% of women with adenocarcinoma of the
breast have Paget disease. Clinically-Paget disease has common dermatitis-like appearance,
as originally described in 1874, when Sir James Paget recorded that such
lesions may resemble “ordinary chronic eczema” or present as nipple erosion or
ulceration. Paget disease often has a deceptively banal clinical morphology but
should lead the list of differential diagnoses when evaluating unilateral
lesions of the nipple–areola complex in adults.
Paget disease presenting with nipple erosion.
Most women with the histopathologic finding of Paget disease
have a clinical abnormality of the nipple. However, in at least 10% of affected
patients, Paget disease is found incidentally, during microscopic examination
of mastectomy specimens.
Underlying invasive ductal carcinoma or DCIS, detected in
more than 90% of patients with Paget disease, is multifocal in about 50% of
cases and does not necessarily occur near or contiguous with the nipple–areola
complex.
In addition, because of the practice shift from mastectomy
to breast-conserving surgery, a patient whose nipple–areola complex was spared
during surgery may present with Paget disease or epidermotropic metastatic
breast cancer to the nipple after diagnosis and treatment of primary breast
cancer.
Histopathology:
Paget disease is characterized by intraepidermal
infiltration with large cells that have abundant pale cytoplasm and
hype...
Source: Oncopathology - Category: Pathologists Tags: Breast Biopsy Procedure Breast Carcinoma vs. Pulmonary Adenocarcinoma a common misdiagnosis. Source Type: blogs
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