Advancing Postoperative Pain Management in Oral Cancer Patients: A Systematic Review
Pharmaceuticals (Basel). 2024 Apr 22;17(4):542. doi: 10.3390/ph17040542.ABSTRACTThe goal of this review is to shed light on the management of orofacial discomfort after a cancer diagnosis in the head and neck region. A search was conducted on PubMed, Scopus, and Web of Science to identify studies on postoperative pain control in oral cancer. The review included open-access research, investigations into pain management, randomized clinical trials, retrospective studies, case-control studies, prospective studies, English-written studies, and full-text publications. Exclusion criteria included animal studies; in vitro studies...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Angelo Michele Inchingolo Gianna Dipalma Alessio Danilo Inchingolo Irene Palumbo Mariafrancesca Guglielmo Roberta Morolla Antonio Mancini Francesco Inchingolo Source Type: research
Rib fracture secondary to cough ‐induced trauma
Chest CT 3D reconstruction showing a linear fracture of the right ninth and tenth ribs (green arrows). Key clinical messageEarly identification of rib fractures, even in young patients without chronic diseases, is essential. Prompt diagnosis facilitates appropriate management, aiding in pain control and addressing underlying causes such as persistent coughing. Additionally, vigilance for complications such as pneumothorax and rib displacement is crucial for optimizing patient care. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 27, 2024 Category: General Medicine Authors: Ahmed Qasim Mohammed Alhatemi,
Hashim Talib Hashim,
Ali Talib Hashim Tags: CASE IMAGE Source Type: research
Associations between health-related quality of life and subsequent need for specialized palliative care and hospital utilization in patients with gastrointestinal cancer —a prospective single-center cohort study
ConclusionThe study indicates a need for interventions in hospital departments to identify and manage the substantial symptom burden experienced by patients, provide palliative care, and ensure timely referral to SPC. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 27, 2024 Category: Cancer & Oncology Source Type: research
Goal setting in people with low back pain attending an education and exercise program (GLA:D Back) and the impact of demographic factors
Individual goal setting is a fundamental element in self-management supportive interventions, serving to guide actions and enhance motivation for engagement. Despite this, little is known about the goals peopl... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - April 27, 2024 Category: Orthopaedics Authors: Mette H.M. Gregersen, Kristine R. Nielsen, Nana H. Lynge, Bibi D. Heiberg, Jan Hartvigsen, Greg Kawchuk and Alice Kongsted Tags: Research Source Type: research
Mechanical ventilation in older adults with dementia: opportunities to promote goal-concordant care
: Recent studies show increasing use of mechanical ventilation among people living with dementia. There are concerns that this trend may not be driven by patient preferences. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 27, 2024 Category: Palliative Care Authors: Lauren R. Pollack, Jamie T. Nomitch, Lois Downey, Sudiptho R. Paul, May J. Reed, Alison M. Uyeda, Whitney A. Kiker, Danae G. Dotolo, Elizabeth Dzeng, Robert Y. Lee, Ruth A. Engelberg, Erin K. Kross Tags: Original Article Source Type: research
Anticonvulsant toxicity
Anticonvulsant medications are used in the treatment of epilepsy as neuropathic pain, migraine and psychiatric illness. Anticonvulsants suppress neuronal excitation to reduce the likelihood of seizure activity. Generally, management is supportive, with correction of physiological and metabolic parameters. Drug concentrations can help guide specific treatments such as l-carnitine (for valproate) and multiple-dose activated charcoal (for carbamazepine, phenytoin and phenobarbital). Extracorporeal treatmen ts can be used to enhance elimination. (Source: Medicine)
Source: Medicine - April 27, 2024 Category: Internal Medicine Authors: Laurence A. Gray Tags: Poisonous substances Source Type: research
Microbial Symphony: Exploring the Role of the Gut in Osteoarthritis-Related Pain. A Narrative Review
AbstractOne of the most common musculoskeletal disorders, osteoarthritis (OA), causes worldwide disability, morbidity, and poor quality of life by degenerating articular cartilage, modifying subchondral bone, and inflaming synovial membranes. OA pathogenesis pathways must be understood to generate new preventative and disease-modifying therapies. In recent years, it has been acknowledged that gut microbiota (GM) can significantly contribute to the development of OA. Dysbiosis of GM can disrupt the “symphony” between the host and the GM, leading to a host immunological response that activates the “gut–joint” axis,...
Source: Pain and Therapy - April 27, 2024 Category: Anesthesiology Source Type: research
Cancers, Vol. 16, Pages 1703: Targeting TRPV4 Channels for Cancer Pain Relief
Trevisan
Despite the unique and complex nature of cancer pain, the activation of different ion channels can be related to the initiation and maintenance of pain. The transient receptor potential vanilloid 4 (TRPV4) is a cation channel broadly expressed in sensory afferent neurons. This channel is activated by multiple stimuli to mediate pain perception associated with inflammatory and neuropathic pain. Here, we focused on summarizing the role of TRPV4 in cancer etiology and cancer-induced pain mechanisms. Many studies revealed that the administration of a TRPV4 antagonist and TRPV4 knockdown diminishes nociception in ...
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Caren Tatiane de David Antoniazzi N áthaly Andrighetto Ruviaro Diulle Spat Peres Patr ícia Rodrigues Fernanda Tibolla Viero Gabriela Trevisan Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1696: Updates in Cancer Cachexia: Clinical Management and Pharmacologic Interventions
abbro
Despite a better understanding of the mechanisms causing cancer cachexia (CC) and development of promising pharmacologic and supportive care interventions, CC persists as an underdiagnosed and undertreated condition. CC contributes to fatigue, poor quality of life, functional impairment, increases treatment related toxicity, and reduces survival. The core elements of CC such as weight loss and poor appetite should be identified early. Currently, addressing contributing conditions (hypothyroidism, hypogonadism, and adrenal insufficiency), managing nutrition impact symptoms leading to decreased oral intake (nausea,...
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Sudeep Pandey Lauren Bradley Egidio Del Fabbro Tags: Review Source Type: research
Clinical efficacy of sodium aescinate administration following endovenous laser ablation for varicose veins
CONCLUSIONS: SA, in combination with compression therapy, can relieve edema and alleviate pain in patients following EVLA for varicose veins.PMID:38670962 | DOI:10.1177/17085381241249288 (Source: Vascular)
Source: Vascular - April 26, 2024 Category: Surgery Authors: Xinrui Yang Jian Jin Siyi Huang Peng Qiu Ruihua Wang Kaichuang Ye Xinwu Lu Source Type: research
Renal artery occlusion in a young woman - a tale of mysterious thrombosis
CONCLUSION: Renal artery thrombosis in young people is extremely rare and presents a diagnostic and management challenge requiring input from multiple teams including nephrology, rheumatology, paediatrics and vascular surgery. Systemic coagulopathy and vasculitis are differentials against anatomical aetiologies such as fibromuscular dysplasia. Our case adds to the limited literature regarding this in the young population. Renal artery thrombosis with occlusion in young people is very rare and is most often associated with a systemic coagulopathic disorder, such as antiphospholipid syndrome or structural pathology of the re...
Source: Vascular - April 26, 2024 Category: Surgery Authors: Ned Farley Joseph Faraj Malindu Fernando Tejas Singh Aaron Powell Senthil Kumar Source Type: research
Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry
This study aims to assess changes in validated patient-reported outcome measures (PROMs) and CBMP clinical safety in patients with osteoarthritis. A prospective case series from the UK Medical Cannabis Registry was analyzed. Primary outcomes were changes in the Brief Pain Inventory (BPI), McGill Pain Questionnaire (MPQ2), EQ-5D-5L, Generalized Anxiety Disorder-7 (GAD-7) questionnaire, and Single-Item Sleep Quality Scale (SQS) at 1-, 3-, 6-, and 12-month follow-ups from baseline. Common Terminology Criteria for Adverse Events v.4.0 was used for adverse event (AE) analysis. Statistical significance was defined as p < 0.05...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 26, 2024 Category: Palliative Care Authors: Ann Francis Simon Erridge Carl Holvey Ross Coomber Wendy Holden James Rucker Michael Platt Mikael Sodergren Source Type: research
Talonavicular-cuneiform arthrodesis in the management of Mueller-Weiss Syndrome: a retrospective case series
This study aimed to present clinical and radiological outcomes of talonavicular-cuneiform (TNC) arthrodesis in the treatment of patients with MWS. A retrospective study was performed on 8 consecutive patients (6 female, 2 male; mean age = 50 years; range = 33-64) who underwent TNC arthrodesis using plate fixation with autologous bone grafting for the treatment of MWS. To evaluate clinical status, the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Midfoot Score was performed immediately preoperatively and at the final follow-up. In radiographic evaluation, talus-first metatarsal angle (Meary's angle) was measured...
Source: Acta Orthopaedica Belgica - April 26, 2024 Category: Orthopaedics Authors: G Uzer M Demirel D Kara B Toker F Yildiz V Ucan Source Type: research
Dorsal wrist plating for the management of intra-articular distal radius fractures
Acta Orthop Belg. 2024 Mar;90(1):110-114. doi: 10.52628/90.1.8058.ABSTRACTThe aim of the study was to evaluate the results of Dorsal Wrist Plating in intra-articular distal radius fractures with a dorsal displacement. In this prospective study, a single surgeon treated 20 patients with a (partially) intra-articular distal radius fracture with a dorsal rim avulsion or a dorsal Barton's type fragment. They all underwent an open reduction and internal fixation by Dorsal Wrist Plating. A total of 17 patients had a follow-up period of at least 12 months (mean follow- up of 17 months) and these patients were included in the stud...
Source: Acta Orthopaedica Belgica - April 26, 2024 Category: Orthopaedics Authors: J Brauns W Vandesande Source Type: research
Clinical outcomes of conservative versus surgical treatment for patients with proximal humeral fracture before physiotherapy
This study aimed to compare kinesiophobia, pain, range of motion (ROM), shoulder function, and Quality of life (QoL) in patients treated with either conservative (CT) versus surgical (ST) after PHF. In addition, it aimed to determine correlations between fear of movement and seconder outcome measures. This cross-sectional study enrolled the patients having 5-6 weeks (being permitted active movement) after being treated either CT or ST and receiving no physical therapy. Pain, passive and active ROMs, shoulder function, fear of movement, and QoL were evaluated. 42 patients were recruited. Kinesiophobia scores were similar (p...
Source: Acta Orthopaedica Belgica - April 26, 2024 Category: Orthopaedics Authors: G Kus A Zengin Alpozgen F Gungor A Razak Ozdincler S Altun Source Type: research
