Predicting the Efficacy of Novel Synthetic Compounds in the Treatment of Osteosarcoma via Anti-Receptor Activator of Nuclear Factor- κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) Targets
CONCLUSION: The analytic scrutiny of both algorithms underscores their commendable reliability in forecasting the efficacy of nascent compounds. A juxtaposition based on correlation coefficients elucidates that the GEP algorithm exhibits superior predictive prowess relative to the HM algorithm for novel synthetic compounds.PMID:38468522 | DOI:10.2174/0115734064287922240222115200 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Wenhua Zhang Siping Xu Peng Liu Xusheng Li Xinyuan Yu Bing Kang Source Type: research
Predicting the Efficacy of Novel Synthetic Compounds in the Treatment of Osteosarcoma via Anti-Receptor Activator of Nuclear Factor- κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) Targets
CONCLUSION: The analytic scrutiny of both algorithms underscores their commendable reliability in forecasting the efficacy of nascent compounds. A juxtaposition based on correlation coefficients elucidates that the GEP algorithm exhibits superior predictive prowess relative to the HM algorithm for novel synthetic compounds.PMID:38468522 | DOI:10.2174/0115734064287922240222115200 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Wenhua Zhang Siping Xu Peng Liu Xusheng Li Xinyuan Yu Bing Kang Source Type: research
Predicting the Efficacy of Novel Synthetic Compounds in the Treatment of Osteosarcoma via Anti-Receptor Activator of Nuclear Factor- κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) Targets
CONCLUSION: The analytic scrutiny of both algorithms underscores their commendable reliability in forecasting the efficacy of nascent compounds. A juxtaposition based on correlation coefficients elucidates that the GEP algorithm exhibits superior predictive prowess relative to the HM algorithm for novel synthetic compounds.PMID:38468522 | DOI:10.2174/0115734064287922240222115200 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Wenhua Zhang Siping Xu Peng Liu Xusheng Li Xinyuan Yu Bing Kang Source Type: research
Intelligent structure prediction and visualization analysis of non-coding RNA in osteosarcoma research
ConclusionThis study represents the first comprehensive bibliometric analysis of the knowledge structure and development of ncRNAs in OS. These findings highlight current research hotspots and frontier directions, offering valuable insights for future studies on the role of ncRNAs in OS (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 12, 2024 Category: Cancer & Oncology Source Type: research
[Retracted] miR ‑133b induces chemoresistance of osteosarcoma cells to cisplatin treatment by promoting cell death, migration and invasion
Oncol Lett. 2024 Feb 26;27(4):175. doi: 10.3892/ol.2024.14308. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/ol.2017.7432.].PMID:38464341 | PMC:PMC10921265 | DOI:10.3892/ol.2024.14308 (Source: Oncology Letters)
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Yonggen Zou Jiexiang Yang Jian Wu Cheng Luo Yuanshuai Huang Source Type: research
Cellular responses to silencing of PDIA3 (protein disulphide-isomerase A3): effects on proliferation, migration and genes in control of active vitamin D
J Steroid Biochem Mol Biol. 2024 Mar 7:106497. doi: 10.1016/j.jsbmb.2024.106497. Online ahead of print.ABSTRACTThe active form of vitamin D, 1,25-dihydroxyvitamin D3, is known to act via VDR (vitamin D receptor), affecting several physiological processes. In addition, PDIA3 (protein disulphide-isomerase A3) has been associated with some of the functions of 1,25-dihydroxyvitamin D3. In the present study we used siRNA-mediated silencing of PDIA3 in osteosarcoma and prostate carcinoma cell lines to examine the role(s) of PDIA3 for 1,25-dihydroxyvitamin D3-dependent responses. PDIA3 silencing affected VDR target genes and sign...
Source: Mol Biol Cell - March 9, 2024 Category: Molecular Biology Authors: Despoina Kermpatsou Frida Olsson Erik W åhlén Ola S öderberg Johan Lennartsson Maria Norlin Source Type: research
Molecular characterization of Golgi apparatus-related genes indicates prognosis and immune infiltration in osteosarcoma
CONCLUSIONS: Our study revealed that patients with osteosarcoma can be divided into two GARGs subgroups. Furthermore, we have developed a GARGs prognostic signature that can accurately forecast the prognosis of osteosarcoma patients.PMID:38460960 | DOI:10.18632/aging.205645 (Source: Aging)
Source: Aging - March 9, 2024 Category: Biomedical Science Authors: Jian Zhang Jiahao Liu Rui Ding Xinxin Miao Jianjian Deng Xiaokun Zhao Tianlong Wu Xigao Cheng Source Type: research
Co-delivery of siAEG-1 and doxorubicin to treat osteosarcoma via nanomicelles for azide-alkyne "click" conjugation of poly(l-lysine) dendrons onto Zein
Int J Biol Macromol. 2024 Mar 7:130729. doi: 10.1016/j.ijbiomac.2024.130729. Online ahead of print.ABSTRACTAstrocyte elevated gene-1 (AEG-1) oncogene is a notorious and evolving target in a variety of human malignancies including osteosarcoma. The RNA interference (RNAi) has been clinically proven to effectively knock down specific genes. To successfully implement RNAi in vivo, protective vectors are required not only to protect unstable siRNAs from degradation, but also to deliver siRNAs to target cells with controlled release. Here, we synthesized a Zein-poly(l-lysine) dendrons non-viral modular system that enables effic...
Source: International Journal of Biological Macromolecules - March 9, 2024 Category: Biochemistry Authors: Jiadong Pang Leilei Huang Yating Lian Zhijie Yuan Fen Wang Li-Ming Zhang Source Type: research
Cellular responses to silencing of PDIA3 (protein disulphide-isomerase A3): effects on proliferation, migration and genes in control of active vitamin D
J Steroid Biochem Mol Biol. 2024 Mar 7:106497. doi: 10.1016/j.jsbmb.2024.106497. Online ahead of print.ABSTRACTThe active form of vitamin D, 1,25-dihydroxyvitamin D3, is known to act via VDR (vitamin D receptor), affecting several physiological processes. In addition, PDIA3 (protein disulphide-isomerase A3) has been associated with some of the functions of 1,25-dihydroxyvitamin D3. In the present study we used siRNA-mediated silencing of PDIA3 in osteosarcoma and prostate carcinoma cell lines to examine the role(s) of PDIA3 for 1,25-dihydroxyvitamin D3-dependent responses. PDIA3 silencing affected VDR target genes and sign...
Source: Mol Biol Cell - March 9, 2024 Category: Molecular Biology Authors: Despoina Kermpatsou Frida Olsson Erik W åhlén Ola S öderberg Johan Lennartsson Maria Norlin Source Type: research
Molecular characterization of Golgi apparatus-related genes indicates prognosis and immune infiltration in osteosarcoma
CONCLUSIONS: Our study revealed that patients with osteosarcoma can be divided into two GARGs subgroups. Furthermore, we have developed a GARGs prognostic signature that can accurately forecast the prognosis of osteosarcoma patients.PMID:38460960 | DOI:10.18632/aging.205645 (Source: Aging)
Source: Aging - March 9, 2024 Category: Biomedical Science Authors: Jian Zhang Jiahao Liu Rui Ding Xinxin Miao Jianjian Deng Xiaokun Zhao Tianlong Wu Xigao Cheng Source Type: research
ZIF ‐8‐Encapsulated Pexidartinib Delivery via Targeted Peptide‐Modified M1 Macrophages Attenuates MDSC‐Mediated Immunosuppression in Osteosarcoma
This study proposes a strategy for ZIF-8-encapsulated pexidartinib delivery via targeted peptide-modified M1 macrophages. Modified macrophages not only have a stronger affinity for tumors but also carry anti-tumor drugs that can act precisely on tumor sites. Through this therapeutic strategy, M1 macrophages achieve a precise, sustained, and improved anti-tumor effect. AbstractAdoptive cellular therapy is a promising strategy for cancer treatment. However, the effectiveness of this therapy is limited by its intricate and immunosuppressive tumor microenvironment. In this study, a targeted therapeutic strategy for macrophage ...
Source: Small - March 8, 2024 Category: Nanotechnology Authors: Jiabao Dong,
Xupeng Chai,
Yucheng Xue,
Shiyun Shen,
Zhuo Chen,
Zetao Wang,
Eloy Yinwang,
Shengdong Wang,
Liang Chen,
Fengfeng Wu,
Hengyuan Li,
Zehao Chen,
Jianbin Xu,
Zhaoming Ye,
Xiongfeng Li,
Qian Lu Tags: Research Article Source Type: research
Exploring the Anti-Cancer Potential of Hispidin: A Comprehensive In Silico and In Vitro Study on Human Osteosarcoma Saos2 Cells
Chem Biodivers. 2024 Mar 8:e202301833. doi: 10.1002/cbdv.202301833. Online ahead of print.ABSTRACTHispidin was initially discovered in basidiomycete Inonotus hispidus (Bull.) P. Karst and this extraordinary compound possesses immense potency and can be extracted from the wild mushroom through specialized bioreactor cultivation techniques. In our study, we isolated it from Inonotus hispidus (Bull.) P. Karst., with a yield of 3.6%. We identified and characterized hispidin through the implementation of spectroscopic techniques such as FTIR, NMR, and MS. Additionally, we utilized Thermogravimetric Analysis for thermal characte...
Source: Chemistry and Biodiversity - March 8, 2024 Category: Biochemistry Authors: Khedidja Benarous Arif Mermer Talia Serseg Aydin Tahmasebifar Houssem Boulebd Abderahmane Linani Source Type: research
Exploring the Anti-Cancer Potential of Hispidin: A Comprehensive In Silico and In Vitro Study on Human Osteosarcoma Saos2 Cells
Chem Biodivers. 2024 Mar 8:e202301833. doi: 10.1002/cbdv.202301833. Online ahead of print.ABSTRACTHispidin was initially discovered in basidiomycete Inonotus hispidus (Bull.) P. Karst and this extraordinary compound possesses immense potency and can be extracted from the wild mushroom through specialized bioreactor cultivation techniques. In our study, we isolated it from Inonotus hispidus (Bull.) P. Karst., with a yield of 3.6%. We identified and characterized hispidin through the implementation of spectroscopic techniques such as FTIR, NMR, and MS. Additionally, we utilized Thermogravimetric Analysis for thermal characte...
Source: Chemistry and Biodiversity - March 8, 2024 Category: Biochemistry Authors: Khedidja Benarous Arif Mermer Talia Serseg Aydin Tahmasebifar Houssem Boulebd Abderahmane Linani Source Type: research
Article review: Brazilin as potential anticancer agent
Brazilin is the main compound in Caesalpinia sappan and Haematoxylum braziletto, which is identified as a homoisoflavonoid based on its molecular structure. These plants are traditionally used as an anti-inflammatory to treat fever, hemorrhage, rheumatism, skin problems, diabetes, and cardiovascular diseases. Recently, brazilin has increased its interest in cancer studies. Several findings have shown that brazilin has cytotoxic effects on colorectal cancer, breast cancer, lung cancer, multiple myeloma, osteosarcoma, cervical cancer, bladder carcinoma, also other cancers, along with numerous facts about its possible mechani...
Source: Frontiers in Pharmacology - March 7, 2024 Category: Drugs & Pharmacology Source Type: research
