Fight Aging! Newsletter, September 20th 2021
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients.
NANOG Expression versus Cellular Senescence
https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/
Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living a...
Source: Fight Aging! - September 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is it Possible to Safely Tip the Balance in Cancer Treatment Towards Cell Death Rather than Cell Senescence?
Most cancer treatments produce a lot of senescent cells in the course of killing cancerous cells. This is thought to be the primary reason as to why cancer survivors have a reduced life expectancy and greater burden of age-related disease. Senescent cells secrete disruptive, inflammatory signals that harm tissue function when consistently present. Growing numbers of senescent cells in old tissues are an important contribution to degenerative aging.
The straightforward approach to this issue would be to treat cancer patients with senolytic therapies to clear senescent cells after the anti-cancer treatment is complete...
Source: Fight Aging! - September 13, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 4th 2019
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice.
Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - November 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Consume their Neighbors
The accumulation of lingering senescent cells is an important contributing cause of degenerative aging. In this intriguing report, researchers note that senescent cells resulting from chemotherapy treatment can consume neighboring cells in order to prolong their survival. This is most likely the case for senescent cells in general, whatever their origin. This cellular cannibalism is probably detrimental to tissue function to some small degree, but, since senescent cells are always a tiny minority of all cells, even in old tissues, it is nowhere near as detrimental as the inflammatory signaling profile that accompanies cell...
Source: Fight Aging! - October 31, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Podcast: Haunted Asylums – Stigmatizing or Just Entertainment?
Each Halloween we encounter the same debate: are haunted asylums stigmatizing or are they simply entertainment? While some may think haunted asylums are tasteless at worst, they don’t feel like they’re an actual detriment to the mental illness community. In this episode, we look at this argument from both sides and really dig into what happens when we use mental illness as a theme for entertainment. While Jackie and Gabe both make great arguments, we toss this question back to you.
Are you offended by haunted asylums or do you see them as harmless entertainment — or something in between? Listen now and decide...
Source: World of Psychology - October 28, 2019 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: General Not Crazy Podcast Stigma Trauma Source Type: blogs
Last Month in Oncology with Dr. Bishal Gyawali: April 2019
By BISHAL GYAWALI, MD
Keynote speech on the JAVELIN not going far enough to improve survival
The treatment landscape for metastatic renal-cell carcinoma has changed dramatically with the introduction of immunotherapies. Unfortunately though, we are promoting combinations over single agents without having much idea of added benefit of each drug. This is an important issue because when we combine two drugs, the only thing we are certain of are the added toxicities. PD-1 inhibitor nivolumab had improved OS when given in second line, however nivolumab was tested in combination with ipilimumab (not as a nivolumab monother...
Source: The Health Care Blog - May 10, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Bishal Gyawali Clinical Trials Oncology PD-1 inhibitor Source Type: blogs
6 Inspiring Books That Will Lift Your Mood
Losing yourself in the pages of a riveting novel or memoir is a legitimate form of therapy. Even better is coming away from the characters and the story with a renewed purpose and sense of hope.
John Green, one of my favorite authors, said “Great books help you understand, and they help you feel understood.” I think that’s true especially for people who struggle with depression and anxiety or some other chronic illness that is stigmatized in our culture. Between the covers of a book, we find a new world that shines some light on our reality.
Here are a few inspiring books that will “help you understand and help you...
Source: World of Psychology - April 18, 2019 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Books Inspiration & Hope Mental Health and Wellness Motivation and Inspiration Self-Help Change In Mood reading uplifting Source Type: blogs
An Interview with Orthopaedic Oncologist Dr. Vincent Ng
Dr. Vincent Ng is an orthopaedic oncologist with the University of Maryland Greenebaum Comprehensive Cancer Center and an Assistant Professor or Orthopaedics with the University of Maryland School of Medicine. Dr. Ng specializes in treating bone cancer and soft tissue sarcoma. Below he answers common questions about orthopaedic oncology.
What is an orthopaedic oncologist? How do they differ from surgical oncologists?
“An orthopaedic oncologist specializes in bone and soft tissue tumors. I treat any adult or pediatric patient with any bone or soft tissue tumor/lesion/mass, whether benign or malignant, whether it is...
Source: Life in a Medical Center - June 2, 2017 Category: Universities & Medical Training Authors: UMMC Tags: Cancer Doctors bone cancer oncology orthopedics Source Type: blogs
MR-HIFU and ThermoDox to Treat Recurrent Childhood Tumors: Interview with AeRang Kim, Principal Investigator
Children’s National Health System and the Celsion Corporation (Lawrenceville, NJ) have recently announced a Phase I clinical trial in the US to determine a safe and tolerable dose of ThermoDox in conjunction with non-invasive magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU). The trial is aimed on young adults and children with recurring solid tumors.
ThermoDox technology consists of liposomes loaded with doxorubicin, a conventional chemotherapeutic drug. Liposomes are small lipid structures which can be used to encapsulate and deliver drugs through the bloodstream. While liposomal doxorubicin formu...
Source: Medgadget - December 6, 2016 Category: Medical Equipment Authors: Conn Hastings Tags: Exclusive Nanomedicine Oncology Source Type: blogs
Fight Aging! Newsletter, July 25th 2016
This study builds on preliminary findings from the first phase of the INTERSTROKE study, which identified ten modifiable risk factors for stroke in 6,000 participants from 22 countries. The full-scale INTERSTROKE study included an additional 20,000 individuals from 32 countries in Europe, Asia, America, Africa and Australia, and sought to identify the main causes of stroke in diverse populations, young and old, men and women, and within subtypes of stroke.
To estimate the proportion of strokes caused by specific risk factors, the investigators calculated the population attributable risk for each factor (PAR; an esti...
Source: Fight Aging! - July 24, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Introducing Viral Cancer Therapies into the Spleen Greatly Improves Outcomes
There are plenty of results from the past decade to illustrate that the methodology by which a therapy is delivered makes a great deal of difference to the outcome in patients. Here, for example, researchers have found a way to improve the performance of viruses engineered to preferentially target cancer cells. We've been hearing less of this approach to cancer in the past few years, given the progress and more widespread support for cancer immunotherapy as a technology platform, but there are still many researchers working on the use of viruses in targeted cancer therapy, and a number of promising studies have resulted.
...
Source: Fight Aging! - July 19, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Matching Fund Donors Sought for SENS Universal Cancer Therapy Crowdfunding
There is a month left to go in the SENS crowdfunding campaign that aims to accelerate development of an important component of a universal cancer therapy, a way to block the mechanisms of telomere lengthening that every type of cancer depends upon. The SENS Research Foundation and Lifespan.io volunteers are looking for donors to put up matching funds of a few thousand dollars or more, in order to take that news and that inducement to a number of conferences and other events over the next few weeks. More than 150 people have donated to the campaign to date, and we'd like to triple that number in the next 30 days.
To ...
Source: Fight Aging! - July 18, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
“For #WorldCancerDay, we’re sharing this case of a child...
"For #WorldCancerDay, we're sharing this case of a child diagnosed with a high-grade osteosarcoma of the left distal femur at age 13. After undergoing limb salvage surgery with implantation of a megaprosthesis plus pre- and post-operative chemotherapy, she is running again. More importantly, she has been cancer-free for two years now because of her care team. Thank you to all the healthcare professionals who support and treat cancer patients like her every day." By figure1 on Instagram Posted on infosnack. (Source: Kidney Notes)
Source: Kidney Notes - February 4, 2016 Category: Urology & Nephrology Authors: Joshua Schwimmer Source Type: blogs
Another child with cancer endangered by alternative medicine
Yesterday, I wrote about the winner of the Nobel Prize in Physiology or Medicine, Youyou Tu, who, after screening 2,000 herbal treatments from traditional Chinese medicine (TCM) for anti-malaria activity, finally discovered Artemisinin. She isolated it from the plant in which it is found, using modern chemistry to isolate it, purify it, and later chemically… (Source: Respectful Insolence)
Source: Respectful Insolence - October 8, 2015 Category: Surgery Authors: Orac Tags: Cancer Complementary and alternative medicine Politics Popular culture Quackery Science chemotherapy jaw law osteosarcoma surgery traditional Chinese medicine Source Type: blogs
When the back pain red flags aren’t enough
$28 million was awarded to a patient for a late diagnosis of a pelvic tumor, an osteosarcoma. This rare cancer presented as a case of low back pain and sciatica. The patient claimed that if the osteosarcoma had been caught earlier that the subsequent surgery would have been avoided.
Could doctors have done better in diagnosing more quickly?
These cases strike fear into all primary care doctors. Which patient has a sinister pathology when the majority of patients with similar symptoms of back pain are due to benign non-life threatening causes?
Continue reading ...
Your patients are rating you online: How to respond. Manage...
Source: Kevin, M.D. - Medical Weblog - April 19, 2015 Category: Journals (General) Authors: Davis Liu, MD Tags: Conditions Cancer Orthopedics Source Type: blogs
