Rare Cancer are Subsets of Common Cancers
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. One of the key ideas developed in the book is that each common diseases is actually an aggregate of cellular processes that are present, individually, in rare diseases. In the case of the common cancers, we can find specific rare diseases that are subsets of the common diseases. Here is an excerpt from Chapter 8: 8.3.3 Inherited syndromes that...
Source: Specified Life - July 9, 2014 Category: Pathologists Tags: cancer syndromes carcinogenesis common cancers common disease familial cancer syndromes genetic disease orphan disease orphan drugs rare cancers rare disease Source Type: blogs
Sunray Appearance: Osteosarcoma
If the lesion grows rapidly but steadily, the periosteum will not have enough time to lay down thin shell of bone, and in such cases, the tiny fibers that connect the periosteum to the bone (Sharpey's fibers) become stretched out perpendicular to the bone. When these fibers ossify, they produce a pattern sometimes called "sunburst" periosteal reaction.
From Sumer's Radiology Site http://www.sumerdoc.blogspot.com -The Top Radiology Magazine. Teleradiology Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - July 24, 2013 Category: Radiologists Authors: Sumer Sethi Source Type: blogs
Silk Scaffolds Provide Good Home for Growing 3D Tumors
Researchers developing new therapies to treat cancer are constantly challenged by the fact that tumors are hard to grow outside the body in three dimensions. Drugs, it turns out, affect a tumor differently depending on its structure, and two dimensional cell cultures don’t offer a testing platform that sufficiently replicates a tumor’s native environment. The result is that too many live animals are used to screen various compounds for safety and efficacy, and the work turns out to be slow and tedious.Now researchers at National University of Singapore have shown that they were able to grow 3D osteosarcoma tum...
Source: Medgadget - June 21, 2013 Category: Technology Consultants Authors: Editors Tags: in the news... Source Type: blogs
Crowdsourcing a Diagnosis With a Scientific Video
László Rosta, PhD published a video in which he tries to find an explanation for the disease of a young boy by offering the video for crowdsourcing. He sent me this particular question:
Do you have any therapeutic ideas which might be curative for inoperable osteosarcoma of the pelvis with pulmonary metastases? Radiotherapy (72 Gy) and chemotherapy (EURAMOS-1 protocol) did not help.
I see more and more attempts at crowdsourcing which is not surprising as the increased use of social media platforms opened the way for communicating with like-minded people worldwide in no time. If you can share the video with oncologists y...
Source: ScienceRoll - June 4, 2013 Category: Geneticists and Genetics Commentators Authors: Dr. Bertalan Meskó Tags: Crowdsourcing Medicine Medicine 2.0 Video Web 2.0 Source Type: blogs
The Fault In Ours Stars (TFIOS): An Insightful Depiction Of Teens Living With Serious Illness
I have to confess that even though I am a grown woman I seem to like many young adult –teenage books (I am still seventeen at heart). I am frequently asking my daughter and nieces about books they enjoyed when I’m looking for something to read. So far the books I have read include some teenage love stories happening in a futuristic dystopia in which the main characters are at risk of dying because of being in a arena fighting other children like in the hunger games; or being at risk of getting injured while performing difficult stunts like jumping from a train like in the divergent series.
The Fault in Ours Sta...
Source: Pallimed: A Hospice and Palliative Medicine Blog - May 8, 2013 Category: Palliative Carer Workers Authors: Jeanette Ross Source Type: blogs
The Fault In Our Stars (TFIOS): An Insightful Depiction Of Teens Living With Serious Illness
I have to confess that even though I am a grown woman I seem to like many young adult–teenage books (I am still seventeen at heart). I am frequently asking my daughter and nieces about books they enjoyed when I’m looking for something to read. So far the books I have read include some teenage love stories happening in a futuristic dystopia in which the main characters are at risk of dying because of being in a arena fighting other children like in the hunger games; or being at risk of getting injured while performing difficult stunts like jumping from a train like in the divergent series.
The Fault in Our Stars (TFIO...
Source: Pallimed: A Hospice and Palliative Medicine Blog - May 8, 2013 Category: Palliative Carer Workers Authors: Jeanette Ross Source Type: blogs
Breast Cancer
Pathophysiology of Breast Cancer
Breast cancer is a:
1) neoplastic transformation of glandular epithelium of the terminal duct unit, lactiferous proximal ducts, or lobules of the breast
2) almost always adenocarcinoma
3) classification is controversial, but most experts recognize in situ (malignant cells do not invade through the basement membrane) and invasive forms
4) in situ types – intraductal (comedo and noncomedo sutypes) in situ, lobular in situ, and papillary in situ
5) invasive types – ductal, lobular, tubular, colloid, and medullary
Signs and Symptoms
1) palpable mass – hard, irregular, no discr...
Source: Inside Surgery - March 21, 2013 Category: Surgeons Authors: Editor Tags: Breast Surgery Oncology adenocarcinoma BRCA1 BRCA2 comedo in situ invasive ductal Li Fraumeni lobular peau d'orange Source Type: blogs
The Power of Social Media
In the past, I've discussed the financial challenges facing those of us who conduct research on rare diseases and the important role private foundations play in facilitating our work. What I haven't mentioned before is the role social media can play in linking researchers with foundations.
As some of you may know, I'm on Twitter. Well... sort of. I've been on Twitter recently about as much as I've been posting on my blog.
But through Twitter, I found the Rally Foundation. Honestly, I'm not sure I would have found them otherwise. I'm sure glad I did, though. They're a fabulous organizat...
Source: Doctor David's Blog - March 14, 2013 Category: Oncologists Tags: Being a Pediatric Oncologist Philanthropy Announcements Source Type: blogs
Cancer Doesn’t Discriminate – another UK guest post
It’s raining outside and a big killer snowstorm is on its way from Kansas. I opened my email this morning to find another interesting blog from the UK. This one is from an osteosarcoma survivor named Becky McGuiness. Like the … Continue reading → (Source: Being Cancer Network)
Source: Being Cancer Network - February 26, 2013 Category: Cancer Authors: Dennis Pyritz Tags: Guest Post * Living with Cancer Anxiety Sarcoma Source Type: blogs
How to start writing about your cancer?
Yesterday I received a comment on my post ‘Should You Write A Cancer Book?’ from an osteosarcoma survivor named Tamara wrote: “I would love to write a book and share my experience with those that are just starting the journey but I don’t know how to start.”
Though cancer is a monumental experience that we’d like to convey to others, our written story is only as compelling as our words make it. More important than how to start writing about cancer is to start knowing yourself as a writer.
Take time to experiment and discover your writing style, tone, and creative process. Do you want to c...
Source: Everything Changes - February 5, 2013 Category: Cancer Authors: Kairol Rosenthal Tags: Uncategorized agents author daily writing practice publishing houses self-publishing Source Type: blogs
USMLE Questions – Characteristic Disease Findings
The United States Medical Licensing Examination (USMLE) is designed to emphasize knowledge of clinical scenarios and clinical pearls, even on Step I. Listed below are some commonly encountered disease findings and characteristics.
Feature
Disease
45, X chromosome
Turner’s syndrome
5-HIAA increased in urine
Carcinoid syndrome
Aganglionic rectum
Hirschsrpung’s disease
Apple-core sign on barium enema
Colon cancer
Arched back (opisthotonos)
Tetanus
Argyll-Robertson pupil
Syphilis
Ash leaf on forehead
Tuberous sclerosis
Auer rods
Acute myelogenous leukemia
Austin Flint murmur
Aortic regurgitation...
Source: Inside Surgery - January 18, 2013 Category: Surgeons Authors: Editor Tags: Surgpedia USMLE diseases findings VMA water hammer pulse Source Type: blogs
