Rare Cancer are Subsets of Common Cancers

In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. One of the key ideas developed in the book is that each common diseases is actually an aggregate of cellular processes that are present, individually, in rare diseases. In the case of the common cancers, we can find specific rare diseases that are subsets of the common diseases. Here is an excerpt from Chapter 8: 8.3.3 Inherited syndromes that cause rare cancers are often associated with increased risk for developing common cancers; hence, the causes of rare cancers are related to the causes of common cancers. Many of the greatest advances in our understanding of common cancers have come through the study of rare familial cancer syndromes in which common types of cancer occur. Here are a few common cancers and the familial syndromes that account for a small percentage of cases.Colon tumors (benign and malignant)- Colorectal cancer hereditary non-polyposis - Polyposis syndrome, mixed hereditary - Turcot syndrome (central nervous system cancer and familial polyposis of the colon) - Mismatch repair gene pmsl1 colorectal cancer hereditary, non-polyposis type 3 included - Checkpoint kinase 2 S. pombe homologue of breast and colorectal cancer susceptibility - Colorectal adenomatous polyposis autosomal ...
Source: Specified Life - Category: Pathologists Tags: cancer syndromes carcinogenesis common cancers common disease familial cancer syndromes genetic disease orphan disease orphan drugs rare cancers rare disease Source Type: blogs