Bile acids induce IL-1 α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells
This study further underlines a mechanistic role for bile acids in the pathogenesis of inflammatory diseases through stimulating the production of pro-inflammatory cytokines and recruitment of innate immune cells. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - November 27, 2023 Category: Allergy & Immunology Source Type: research
Association of low-dose ionising radiation with site-specific solid cancers: Chinese medical X-ray workers cohort study, 1950-1995
Conclusions
These findings provided more useful insights into the risks of site-specific cancers from protracted low-dose rate exposure to ionising radiation. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - November 23, 2023 Category: Occupational Health Authors: Gu, Y., Wang, J., Wang, Y., Xu, C., Liu, Y., Du, L., Wang, Q., Ji, K., He, N., Zhang, M., Song, H., Niu, K., Liu, Q. Tags: Workplace Source Type: research
Endoscopic submucosal dissection for oesophageal cavernous haemangioma accompanied by squamous epithelial dysplasia
A 70-year-old man with dysphagia presented to our hospital. Gastroscopy revealed a submucosal eminence with a bluish surface in the anterior wall of the oesophagus 20 –23 cm from the incisor, which was soft to the touch (Fig. 1A). Endoscopic ultrasound (EUS) showed a 10.5 × 18.5 mm hypoechoic and homogeneous mass in the submucosal layer (Fig. 1B). The patient was initially diagnosed with a submucosal bulge of the oesophagus, and atypical hemangioma was t he first consideration. A subsequent computed tomography (CT) scan confirmed the presence and location of the lesion (Fig. 2). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - November 18, 2023 Category: Gastroenterology Authors: Chen Wu, Yuwen Pang, Xiangyu Liu, Lingyun Wang Tags: Image of the Month Source Type: research
Barretts oesophagus with indefinite for dysplasia shows high rates of prevalent and incident neoplasia in a UK multicentre cohort
Conclusions
IDD carries significant risk of progression to dysplasia or neoplasia. Therefore, careful diagnosis and management aided by clear histological reporting of these cases is required to diagnose prevalent and incident neoplasia. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - November 17, 2023 Category: Pathology Authors: Kopczynska, M., Ratcliffe, E., Yalamanchili, H., Thompson, A., Nimri, A., Britton, J., Ang, Y. Tags: Original research Source Type: research
Correlation of the Geriatric Assessment with Overall Survival in Older Patients with Cancer
DISCUSSION: The geriatric assessment is a powerful prognostic tool for survival among older Indian patients with cancer. The geriatric assessment is prognostic even in the cohort of patients thought to be the fittest, i.e. performance status 0 and 1. Our study re-emphasises the critical importance of the geriatric assessment in all older patients planned for cancer-directed therapy.PMID:37953073 | DOI:10.1016/j.clon.2023.11.003 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - November 12, 2023 Category: Cancer & Oncology Authors: A R Rao V Noronha A Ramaswamy A Kumar A Pillai S Gattani A Sehgal S Kumar R Castelino R Dhekale J Krishnamurthy S Mahajan A Daptardar L Sonkusare J Deodhar N Ansari M Vagal P Mahajan S Timmanpyati M Nookala A Chitre A Kapoor V Gota S Banavali R A Badwe K Source Type: research
Sems Sensibility: Biliary Stent Migration into the Oesophagus
We report a case of a patient affected by cancer of the pancreas who was treated with a proximal metallic biliary stent. The stent migrated to the oesophagus and was endoscopically removed. Proximal migration, although rare, should be kept in mind as a potential complication of the procedure. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - November 11, 2023 Category: Gastroenterology Source Type: research
Opium use and risk of colorectal cancer: a multi-center case-referent study in Iran
CONCLUSION: There seems to be no overall association between opium use and CRC, but the risk of CRC might be increased among persons who use opium many times a day.PMID:37934078 | DOI:10.1080/0284186X.2023.2276326 (Source: Acta Oncologica)
Source: Acta Oncologica - November 7, 2023 Category: Cancer & Oncology Authors: Maryam Hadji Maryam Marzban Hamideh Rashidian Ahmad Naghibzadeh-Tahami Mahin Gholipour Elham Mohebbi Roya Safari-Faramani Monireh Sadat Seyyedsalehi Bayan Hosseini Reza Alizadeh-Navaei Abbas Rezaianzadeh Abdolvahab Moradi Soodabeh ShahidSales Farid Najafi Source Type: research
Mechanical experimentation of the gastrointestinal tract: a systematic review
Biomech Model Mechanobiol. 2023 Nov 8. doi: 10.1007/s10237-023-01773-8. Online ahead of print.ABSTRACTThe gastrointestinal (GI) organs of the human body are responsible for transporting and extracting nutrients from food and drink, as well as excreting solid waste. Biomechanical experimentation of the GI organs provides insight into the mechanisms involved in their normal physiological functions, as well as understanding of how diseases can cause disruption to these. Additionally, experimental findings form the basis of all finite element (FE) modelling of these organs, which have a wide array of applications within medici...
Source: Biomechanics and Modeling in Mechanobiology - November 7, 2023 Category: Biomedical Science Authors: Ciara Durcan Mokarram Hossain Gr égory Chagnon Djordje Peri ć Edouard Girard Source Type: research
Opium use and risk of colorectal cancer: a multi-center case-referent study in Iran
CONCLUSION: There seems to be no overall association between opium use and CRC, but the risk of CRC might be increased among persons who use opium many times a day.PMID:37934078 | DOI:10.1080/0284186X.2023.2276326 (Source: Acta Oncologica)
Source: Acta Oncologica - November 7, 2023 Category: Cancer & Oncology Authors: Maryam Hadji Maryam Marzban Hamideh Rashidian Ahmad Naghibzadeh-Tahami Mahin Gholipour Elham Mohebbi Roya Safari-Faramani Monireh Sadat Seyyedsalehi Bayan Hosseini Reza Alizadeh-Navaei Abbas Rezaianzadeh Abdolvahab Moradi Soodabeh ShahidSales Farid Najafi Source Type: research
Mechanical experimentation of the gastrointestinal tract: a systematic review
Biomech Model Mechanobiol. 2023 Nov 8. doi: 10.1007/s10237-023-01773-8. Online ahead of print.ABSTRACTThe gastrointestinal (GI) organs of the human body are responsible for transporting and extracting nutrients from food and drink, as well as excreting solid waste. Biomechanical experimentation of the GI organs provides insight into the mechanisms involved in their normal physiological functions, as well as understanding of how diseases can cause disruption to these. Additionally, experimental findings form the basis of all finite element (FE) modelling of these organs, which have a wide array of applications within medici...
Source: Biomechanics and Modeling in Mechanobiology - November 7, 2023 Category: Biomedical Science Authors: Ciara Durcan Mokarram Hossain Gr égory Chagnon Djordje Peri ć Edouard Girard Source Type: research
Mechanical experimentation of the gastrointestinal tract: a systematic review
Biomech Model Mechanobiol. 2023 Nov 8. doi: 10.1007/s10237-023-01773-8. Online ahead of print.ABSTRACTThe gastrointestinal (GI) organs of the human body are responsible for transporting and extracting nutrients from food and drink, as well as excreting solid waste. Biomechanical experimentation of the GI organs provides insight into the mechanisms involved in their normal physiological functions, as well as understanding of how diseases can cause disruption to these. Additionally, experimental findings form the basis of all finite element (FE) modelling of these organs, which have a wide array of applications within medici...
Source: Biomechanics and Modeling in Mechanobiology - November 7, 2023 Category: Biomedical Science Authors: Ciara Durcan Mokarram Hossain Gr égory Chagnon Djordje Peri ć Edouard Girard Source Type: research
Association of low-dose ionising radiation with site-specific solid cancers: Chinese medical X-ray workers cohort study, 1950-1995
CONCLUSIONS: These findings provided more useful insights into the risks of site-specific cancers from protracted low-dose rate exposure to ionising radiation.PMID:37918914 | DOI:10.1136/oemed-2023-108875 (Source: Cancer Control)
Source: Cancer Control - November 2, 2023 Category: Cancer & Oncology Authors: Yeqing Gu Jinhan Wang Yan Wang Chang Xu Yang Liu Liqing Du Qin Wang Kaihua Ji Ningning He Manman Zhang Huijuan Song Kaijun Niu Qiang Liu Source Type: research
Oesophageal injury
is a rare but serious event, which is potentially fatal. Morbidity remains high even with prompt treatment. Injuries can be described as either partial or full-thickness wall disruption. They may not present typically and a high index of suspicion is required for successful diagnosis, taking into account history and examination findings. All patients should be discussed with a centre which treats high volumes of oesophageal cases, and initial management should focus on general resuscitation principles with an early decision for definitive care. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - October 31, 2023 Category: Surgery Authors: Nima Abbassi-Ghadi, Emily Moore Tags: Oesophagus and stomach Source Type: research
Ethical and legal implications of implementing risk algorithms for early detection and screening for oesophageal cancer, now and in the future
ConclusionsNovel pathways incorporating risk prediction algorithms hold considerable promise, especially when combined with low-cost sampling. However immediate priorities should be to develop risk communication strategies that take account of using validated risk algorithms, and to ensure equitable implementation. Resolving questions about liability for harms arising should be a longer-term objective. (Source: PLoS One)
Source: PLoS One - October 30, 2023 Category: Biomedical Science Authors: Tanya Brigden Source Type: research
