Intermolecular interactions between natural humic substances and tricyclic antidepressants
Publication date: July–August 2019Source: Mendeleev Communications, Volume 29, Issue 4Author(s): Ekaterina D. Mordvinova, Marina V. Parkhats, Yong Chen, Ivan P. PozdnyakovIntermolecular interactions between humic substances (HSs) and the tricyclic antidepressants (TAs) amitriptyline, nortriptyline, imipramine and desipramine were detected for the first time by fluorescence spectroscopy. Two simplest models assuming coordination of one or two of TA molecules at the binding centers of HSs were proposed to explain the photodegradation of TAs caused by sunlight photolysis of humic substances.Graphical abstract (Source: Mendeleev Communications)
Source: Mendeleev Communications - August 15, 2019 Category: Chemistry Source Type: research
Practical LC-MS/MS method for the simultaneous quantification of amitriptyline, nortriptyline and their hydroxy-metabolites in human serum.
Abstract
Amitriptyline has been in use for decades in depression and more recently for the management of neuropathic pain. A highly sensitive and specific LC-MS/MS method was developed for simultaneous determination of amitriptyline [AMI], its active metabolite nortriptyline [NOR] and their hydroxy-metabolites in human serum, using deuterated AMI and NOR as internal standards. The isobaric E-10-hydroxyamitriptyline [E-OH AMI], Z-10-hydroxyamitriptyline [Z-OH AMI], E-10-hydroxynortriptyline [E-OH NOR] and Z-10-hydroxynortriptyline [Z-OH NOR], together with their parent compounds, were separated on an ACE C-...
Source: Biomedical Chromatography : BMC - August 14, 2019 Category: Biomedical Science Authors: Mifsud Buhagiar L, Sammut C, Chircop Y, Axisa K, Sammut Bartolo N, Vella Szijj J, Serracino Inglott A, LaFerla G Tags: Biomed Chromatogr Source Type: research
Commutability of proficiency testing material containing amitriptyline and nortriptyline: A study within the framework of the Dutch Calibration 2.000 project
ConclusionsThe PTM used for amitriptyline and nortriptyline is preferably prepared with human serum, although not all relative residuals are within the commutability decision limit. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - July 30, 2019 Category: Laboratory Medicine Source Type: research
Commutability of proficiency testing material containing amitriptyline and nortriptyline: A study within the framework of the Dutch Calibration 2.000 project.
CONCLUSIONS: The PTM used for amitriptyline and nortriptyline is preferably prepared with human serum, although not all relative residuals are within the commutability decision limit.
PMID: 31374190 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - July 29, 2019 Category: Chemistry Authors: Robijns K, Boone NW, Jansen RTP, Kuypers AWHM, Neef C, Touw DJ Tags: Clin Chim Acta Source Type: research
Experimental and Clinical Pharmacokinetics of Fluoxetine and Amitriptyline: Comparative Analysis and Possible Methods of Extrapolation
The pharmacokinetics of two fluoxetine capsulated dosage forms and two amitriptyline tablet forms after a single oral intake was studied in dogs and healthy volunteers. High significant correlations were detected between plasma concentrations of fluoxetine (r=0.96,p<0.00001,n=11) and amitriptyline (r=0.78,p<0.0224,n=8) in dogs and volunteers. A correlation of medium strength (though insignificant) was detected between nortriptyline concentrations in the plasma of dogs and volunteers (r=0.69,p<0.199,n=5). The bioavailability parameters of the test drugs in dogs and volunteers did not differ. Similar trends of fluox...
Source: Bulletin of Experimental Biology and Medicine - July 25, 2019 Category: Biology Source Type: research
Trajectories of Suicidal Ideation During 12 Weeks of Escitalopram or Nortriptyline Antidepressant Treatment Among 811 Patients With Major Depressive Disorder.
CONCLUSION: Approximately 1 of 5 patients with MDD showed high or fluctuating suicidal ideation despite antidepressant treatment. Studies should investigate whether suicidal ideation may persist for longer periods and more targeted treatment possibilities.
TRIAL REGISTRATION: ISRCTN identifier: ISRCTN03693000.
PMID: 31318184 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 19, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
IJERPH, Vol. 16, Pages 2255: Indices of Change, Expectations, and Popularity of Biological Treatments for Major Depressive Disorder between 1988 and 2017: A Scientometric Analysis
Conclusions. This scientometric analysis represents comprehensive evidence on the popularity and change in prospects of biological treatments for MDD from 1988 to 2017. The popularity of SSRI peaked between 1998 and 2002, when their efficacy, tolerability and safety profile allowed them to replace the TCAs and MAOIs. While the newer neurostimulation therapies are gaining momentum, the popularity of ECT has sustained. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - June 25, 2019 Category: Environmental Health Authors: Bach X. Tran Giang H. Ha Giang T. Vu Long H. Nguyen Carl A. Latkin Kalpana Nathan Roger S. McIntyre Cyrus S. Ho Wilson W. Tam Roger C. Ho Tags: Article Source Type: research
CMA accuses four pharmaceutical companies of breaking competition law on supply of antidepressant
The Competition and Markets Authority has provisionally found four pharmaceutical companies to have broken completion law in relation to supply of nortriptyline, a tricyclic antidepressant. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - June 20, 2019 Category: Drugs & Pharmacology Source Type: research
Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation.
CONCLUSIONS: There is high-certainty evidence that providing behavioural support in person or via telephone for people using pharmacotherapy to stop smoking increases quit rates. Increasing the amount of behavioural support is likely to increase the chance of success by about 10% to 20%, based on a pooled estimate from 65 trials. Subgroup analysis suggests that the incremental benefit from more support is similar over a range of levels of baseline support. More research is needed to assess the effectiveness of specific components that comprise behavioural support.
PMID: 31166007 [PubMed - as supplied by publisher] ...
Source: Cochrane Database of Systematic Reviews - June 4, 2019 Category: General Medicine Authors: Hartmann-Boyce J, Hong B, Livingstone-Banks J, Wheat H, Fanshawe TR Tags: Cochrane Database Syst Rev Source Type: research
Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants Randomized.
CONCLUSION: Solutions to these challenges, including early inclusion of stake holders, will inform future pragmatic studies in older adults with depression.
PMID: 31147244 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - June 1, 2019 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
F93. CYP2D6 Revisited in GENDEP, a Multicenter Clinical Trial of Nortriptyline and Escitalopram
The polymorphic CYP2D6 enzyme is estimated to be responsible for the oxidation of 20-25% of all drugs in clinical use. However, genotyping for its variants is not routinely clinically available. The gene is particularly complex, with different platforms analysing different subsets of variants. GENDEP (Genome-based therapeutic drugs for depression) is a multicentre clinical trial which found an association between CYP2D6 genotype and nortriptyline concentration, but no association between CYP2D6 or CYP2C19 and response to nortriptyline. (Source: Biological Psychiatry)
Source: Biological Psychiatry - May 13, 2019 Category: Psychiatry Authors: Katherine Aitchison, Rohit J. Lodhi, Yabing Wang, Beatriz Carvalho Henriques, Xiuying Hu, Dawon Lee, Diego Lomnitzer Lapetina, Joanna Hauser, Wolfgang Maier, Mojca Z. Dernovsek, Neven Henigsberg, Daniel Souery, Annamaria Cattaneo, Ole Mors, Marcella Riets Source Type: research
Dexamethasone changes the pharmacokinetics of amitriptyline and reduces its accumulation in rat brain: the roles of P-gp and cyp3a2
In this study, we used amitriptyline (AMI) and dexamethasone (DEX) as the corresponding poisoning and pre-protecting drugs, respectively, to study whether DEX has the potential to reduce AMI accumulation in brain. By measuring the pharmacokinetic data of AMI and its main metabolite nortriptyline (NOR), we found that DEX possibly accelerated the metabolism and elimination of AMI with minimal effects on the concentrations of NOR in blood. Nevertheless, the results indicated that DEX reduced the brain/plasma concentration ratio of AMI and NOR, even if the plasma concentration of NOR had an upward trend. Western blot results s...
Source: Journal of Pharmacological Sciences - May 5, 2019 Category: Drugs & Pharmacology Source Type: research
Nortriptyline Abuse: A Case Report and Review of the Literature
This article reviews the prior literature in regard to tricyclic antidepressants and anticholinergics as substances of abuse, the proposed mechanisms of this, and susceptible populations, as well as a case review of a patient who admitted to using nortriptyline for its “buzz.” (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2019 Category: Neurology Tags: Case Reports Source Type: research
Carbon monoxide releasing molecule 401 (CORM-401) modulates phase I metabolism of xenobiotics.
Abstract
Next to its well-studied toxicity, carbon monoxide (CO) is recognized as a signalling molecule in various cellular processes. Thus, CO-releasing molecules (CORMs) are of considerable interest for basic research and drug development. Aim of the present study was to investigate if CO, released from CORMs, inhibits cytochrome P450-dependent monooxygenase (CYP) activity and modulates xenobiotic metabolism. CORM-401 was used as a model CO delivering compound; inactive CORM-401 (iCORM-401), unable to release CO, served as control compound. CO release from CORM-401, but not from iCORM-401, was validated ...
Source: Toxicology in Vitro - April 16, 2019 Category: Toxicology Authors: Walter M, Stahl W, Brenneisen P, Reichert AS, Stucki D Tags: Toxicol In Vitro Source Type: research
Extent and Predictors of Potentially Inappropriate Antidepressant Use Among Older Adults With Dementia and Major Depressive Disorder.
CONCLUSION: More than 7% of older adults in the study sample initiated a potentially inappropriate antidepressant, and the authors identified a few individual-level factors significantly associated with it. Appropriately tailored interventions to address modifiable and nonmodifiable factors significantly associated with potentially inappropriate antidepressant prescribing are required to minimize risks in this vulnerable population.
PMID: 30926273 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - March 31, 2019 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
