Pharmacological management of fibromyalgia: a Bayesian network meta-analysis
Expert Rev Clin Pharmacol. 2022 Feb 23:1-10. doi: 10.1080/17512433.2022.2044792. Online ahead of print.ABSTRACTINTRODUCTION: The identification of the most effective therapy for patients with fibromyalgia (FM) remains controversial. Thus, we conducted a Bayesian network meta-analysis to compare several drugs employed as pharmacological management for FM.AREAS COVERED: The following databases were accessed in October 2021: PubMed, Google Scholar, Embase, and Scopus. All the randomized clinical trials (RCTs) that compare two or more pharmacological management for fibromyalgia were accessed. Only studies involving a minimum o...
Source: Pharmacological Reviews - February 21, 2022 Category: Drugs & Pharmacology Authors: Filippo Migliorini Nicola Maffulli J örg Eschweiler Matthias Knobe Markus Tingart Giorgia Colarossi Source Type: research
A prospective study examining the effect of selected topical and systemic drugs on pruritus grading system score and stat 6 expression in patients of prurigo nodularis
Conclusion: A combination of selected oral and topical agents can effectively control the severity of PN within one month, and this was found to correlate with STAT 6 expression. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - January 28, 2022 Category: Dermatology Authors: Diksha Agrawal Kabir Sardana Sinu R Mathachan Minakshi Bhardwaj Arvind Ahuja Swasti Jain Source Type: research
[ASAP] Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule Soft Constraints
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.1c00919 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - January 20, 2022 Category: Drugs & Pharmacology Authors: Olivera S. Markovic ́, Nirali G. Patel, Abu T. M. Serajuddin, Alex Avdeef, and Tatjana Ž. Verbić Source Type: research
The preventive effect of the combination of atorvastatin and nortriptyline in migraine-type headache: a randomized, triple-blind, placebo-controlled trial
CONCLUSION: In patients with migraine, prophylaxis with atorvastatin significantly improved the frequency of headache and QOL over 24 weeks compared with placebo with no effect on the intensity of headache. Statins seem to be a potential promising drug for prophylaxis of migraine headaches.PMID:35037597 | DOI:10.1080/01616412.2021.1981105 (Source: Neurological Research)
Source: Neurological Research - January 17, 2022 Category: Neurology Authors: Amir Sherafat Adeleh Sahebnasagh Roya Rahmany Farhad Mohammadi Fatemeh Saghafi Source Type: research
Electrochemical sensor for tricyclic antidepressants with low nanomolar detection limit: Quantitative Determination of Amitriptyline and Nortriptyline in blood
Talanta. 2021 Nov 15;239:123072. doi: 10.1016/j.talanta.2021.123072. Online ahead of print.ABSTRACTAmitriptyline and its metabolite, Nortriptyline are commonly used tricyclic antidepressant (TCA) drugs that are electrochemically active. In this work, the performance characteristics of a plasticized PVC membrane-coated glassy carbon (GC) electrode are described for the voltammetric quantification of Amitriptyline and Nortriptyline in whole blood. The highly lipophilic Amitriptyline and Nortriptyline preferentially partition into the plasticized PVC membrane where the free drug is oxidized on the GC electrode. The concentrat...
Source: Talanta - December 5, 2021 Category: Chemistry Authors: Marcin Guzinski Ern ő Lindner Bradford Pendley Edward Chaum Source Type: research
Effectiveness of perampanel in managing chronic pain caused by the complex regional pain syndrome: A case report
This report describes a patient with complex regional pain syndrome (CRPS) type I in the right lower leg and foot who responded well to perampanel, an AMPA receptor antagonist, for managing the chronic pain.
Patient concern:
A 61-year-old woman complained of pain in her right lower leg and foot over a period of 7 year (numeric rating scale: 8) due to CRPS type I.
Diagnosis:
CRPS type 1.
Interventions:
Despite the combination of 300 mg pregabalin, 225 mg/1950 mg tramadol/acetaminophen, and 10 mg nortriptyline per day, her right lower leg and foot were nearly disabled due to the severity of the p...
Source: Medicine - December 3, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
Ferroptosis, an iron-dependent nonapoptotic cell death, is a highly regulated tumor suppressing process. However, functions and mechanisms of RNA-binding proteins in regulation of evasion of ferroptosis during lung cancer progression are still largely unknown. Here, we report that the RNA-binding protein RBMS1 participates in lung cancer development via mediating ferroptosis evasion. Through an shRNA-mediated systematic screen, we discovered that RBMS1 is a key ferroptosis regulator. Clinically, RBMS1 was elevated in lung cancer and its high expression was associated with reduced patient survival. Conversely, depletion of ...
Source: Journal of Clinical Investigation - November 15, 2021 Category: Biomedical Science Authors: Wenjing Zhang, Yu Sun, Lu Bai, Lili Zhi, Yun Yang, Qingzhi Zhao, Chaoqun Chen, Yangfan Qi, Wenting Gao, Wenxia He, Luning Wang, Dan Chen, Shujun Fan, Huan Chen, Hai-Long Piao, Qinglong Qiao, Zhaochao Xu, Jinrui Zhang, Jinyao Zhao, Sirui Zhang, Yue Yin, Ch Source Type: research
Dimensions of temperament and character as predictors of antidepressant discontinuation, response and adverse reactions during treatment with nortriptyline and escitalopram
CONCLUSIONS: This study, representing the largest investigation between several personality traits and response to two different antidepressants, suggests that correlations between personality traits and antidepressant treatment response may be confounded by differential rates of discontinuation. Future trials on personality in the treatment of depression need to consider this interdependency and study whether interventions aiming at improving compliance for some personality types may improve response to antidepressants.PMID:34763734 | DOI:10.1017/S003329172100444X (Source: Psychological Medicine)
Source: Psychological Medicine - November 12, 2021 Category: Psychiatry Authors: Ole K öhler-Forsberg Robert Keers Rudolf Uher Joanna Hauser Wolfgang Maier Marcella Rietschel Peter McGuffin Anne E Farmer Katherine J Aitchison Ole Mors Source Type: research
Dimensions of temperament and character as predictors of antidepressant discontinuation, response and adverse reactions during treatment with nortriptyline and escitalopram
CONCLUSIONS: This study, representing the largest investigation between several personality traits and response to two different antidepressants, suggests that correlations between personality traits and antidepressant treatment response may be confounded by differential rates of discontinuation. Future trials on personality in the treatment of depression need to consider this interdependency and study whether interventions aiming at improving compliance for some personality types may improve response to antidepressants.PMID:34763734 | DOI:10.1017/S003329172100444X (Source: Psychological Medicine)
Source: Psychological Medicine - November 12, 2021 Category: Psychiatry Authors: Ole K öhler-Forsberg Robert Keers Rudolf Uher Joanna Hauser Wolfgang Maier Marcella Rietschel Peter McGuffin Anne E Farmer Katherine J Aitchison Ole Mors Source Type: research
Dimensions of temperament and character as predictors of antidepressant discontinuation, response and adverse reactions during treatment with nortriptyline and escitalopram
CONCLUSIONS: This study, representing the largest investigation between several personality traits and response to two different antidepressants, suggests that correlations between personality traits and antidepressant treatment response may be confounded by differential rates of discontinuation. Future trials on personality in the treatment of depression need to consider this interdependency and study whether interventions aiming at improving compliance for some personality types may improve response to antidepressants.PMID:34763734 | DOI:10.1017/S003329172100444X (Source: Psychological Medicine)
Source: Psychological Medicine - November 12, 2021 Category: Psychiatry Authors: Ole K öhler-Forsberg Robert Keers Rudolf Uher Joanna Hauser Wolfgang Maier Marcella Rietschel Peter McGuffin Anne E Farmer Katherine J Aitchison Ole Mors Source Type: research
Antidepressants Effects on Pain in Parkinson Disease: A Systematic Review
Conclusions
Prospective studies with a direct comparison of antidepressants and placebo should be conducted, focusing on pain-related scales and questions to understand further the role of antidepressants in treating pain in PD. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2021 Category: Neurology Tags: Review Articles Source Type: research
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
J Clin Invest. 2021 Oct 5:e152067. doi: 10.1172/JCI152067. Online ahead of print.ABSTRACTFerroptosis, an iron-dependent non-apoptotic cell death, is a highly regulated tumor suppressing process. However, functions and mechanisms of RNA binding proteins in regulation of evasion of ferroptosis during lung cancer progression are still largely unknown. Here we reported that the RNA binding protein RBMS1 participated in lung cancer development through mediating ferroptosis evasion. Through an shRNA-mediated systematic screen, we discovered that RBMS1 was a key ferroptosis regulator. Clinically, RBMS1 was elevated in lung cancer...
Source: Clinical Lung Cancer - October 5, 2021 Category: Cancer & Oncology Authors: Wenjing Zhang Yu Sun Lu Bai Lili Zhi Yun Yang Qingzhi Zhao Chaoqun Chen Yangfan Qi Wenting Gao Wenxia He Luning Wang Dan Chen Shujun Fan Huan Chen Hai-Long Piao Qinglong Qiao Zhaochao Xu Jinrui Zhang Jinyao Zhao Sirui Zhang Yue Yin Chao Peng Xiaoling Li Q Source Type: research
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
J Clin Invest. 2021 Oct 5:e152067. doi: 10.1172/JCI152067. Online ahead of print.ABSTRACTFerroptosis, an iron-dependent non-apoptotic cell death, is a highly regulated tumor suppressing process. However, functions and mechanisms of RNA binding proteins in regulation of evasion of ferroptosis during lung cancer progression are still largely unknown. Here we reported that the RNA binding protein RBMS1 participated in lung cancer development through mediating ferroptosis evasion. Through an shRNA-mediated systematic screen, we discovered that RBMS1 was a key ferroptosis regulator. Clinically, RBMS1 was elevated in lung cancer...
Source: Clinical Lung Cancer - October 5, 2021 Category: Cancer & Oncology Authors: Wenjing Zhang Yu Sun Lu Bai Lili Zhi Yun Yang Qingzhi Zhao Chaoqun Chen Yangfan Qi Wenting Gao Wenxia He Luning Wang Dan Chen Shujun Fan Huan Chen Hai-Long Piao Qinglong Qiao Zhaochao Xu Jinrui Zhang Jinyao Zhao Sirui Zhang Yue Yin Chao Peng Xiaoling Li Q Source Type: research
Volatile free liquid membranes for electromembrane extraction
Anal Chim Acta. 2021 Oct 16;1182:338959. doi: 10.1016/j.aca.2021.338959. Epub 2021 Aug 16.ABSTRACTVolatile solvents are excellent extraction media for liquid-liquid extractions. However, their use in supported liquid membranes (SLMs) is limited by their evaporation from SLM and thus poor SLM stability and they have never been considered truly useful for electromembrane extraction (EME). In this contribution, volatile solvents were systematically investigated as liquid membranes for EME and their extraction characteristics were comprehensively examined for the first time. A short plug of a water immiscible volatile solvent ...
Source: Analytica Chimica Acta - October 4, 2021 Category: Chemistry Authors: Andrea Šlampová Pavel Kub áň Source Type: research
Volatile free liquid membranes for electromembrane extraction
Anal Chim Acta. 2021 Oct 16;1182:338959. doi: 10.1016/j.aca.2021.338959. Epub 2021 Aug 16.ABSTRACTVolatile solvents are excellent extraction media for liquid-liquid extractions. However, their use in supported liquid membranes (SLMs) is limited by their evaporation from SLM and thus poor SLM stability and they have never been considered truly useful for electromembrane extraction (EME). In this contribution, volatile solvents were systematically investigated as liquid membranes for EME and their extraction characteristics were comprehensively examined for the first time. A short plug of a water immiscible volatile solvent ...
Source: Analytica Chimica Acta - October 4, 2021 Category: Chemistry Authors: Andrea Šlampová Pavel Kub áň Source Type: research
