Volatile free liquid membranes for electromembrane extraction
Anal Chim Acta. 2021 Oct 16;1182:338959. doi: 10.1016/j.aca.2021.338959. Epub 2021 Aug 16.ABSTRACTVolatile solvents are excellent extraction media for liquid-liquid extractions. However, their use in supported liquid membranes (SLMs) is limited by their evaporation from SLM and thus poor SLM stability and they have never been considered truly useful for electromembrane extraction (EME). In this contribution, volatile solvents were systematically investigated as liquid membranes for EME and their extraction characteristics were comprehensively examined for the first time. A short plug of a water immiscible volatile solvent ...
Source: Analytica Chimica Acta - October 4, 2021 Category: Chemistry Authors: Andrea Šlampová Pavel Kub áň Source Type: research
Therapeutic Drug Monitoring of Psychotropics as a Diagnostic Tool for CYP2D6 Poor Metabolizer Phenotype
Conclusions:
If therapeutic drug monitoring is available, the thresholds presented here could serve as a diagnostic tool for the CYP2D6 PM phenotype of psychiatric patients prescribed the aforementioned psychotropic medications. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - September 19, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
The effect of smoking on the plasma concentration of tricyclic antidepressants - a systematic review
CONCLUSION: The effect of smoking on the plasma concentration of TCAs is still not entirely clear. There is a possibility that smoking affects the distribution of TCA metabolites, but this is probably not of clinical importance.PMID:34497000 | DOI:10.1017/neu.2021.28 (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - September 9, 2021 Category: Psychiatry Authors: Nicklas Hasselblad Lundstr øm Nikolaj K Holgersen Maija Bruun Haastrup Source Type: research
A Scoping Review of Interventions for Spousal Bereavement in Older Adults
Am J Geriatr Psychiatry. 2021 Aug 16:S1064-7481(21)00423-1. doi: 10.1016/j.jagp.2021.08.002. Online ahead of print.ABSTRACTThe loss of a spouse is a common and natural life event for older adults. Nearly one of four older bereaved spouses experience prolonged grief, impaired function or chronic depression. Mechanisms underlying these and other long-term health risks are not well understood. We conducted a scoping literature review to examine the interventions and outcomes that have been studied for late-life spousal bereavement to date. We identified 22 studies of group and individual-level interventions with most studies ...
Source: Am J Geriatr Psychia... - September 8, 2021 Category: Geriatrics Authors: Jennie B Davidow Benjamin S Zide Leonard L Levin Kelsey D Biddle Juan Carlos Urizar Nancy J Donovan Source Type: research
A Scoping Review of Interventions for Spousal Bereavement in Older Adults
Am J Geriatr Psychiatry. 2021 Aug 16:S1064-7481(21)00423-1. doi: 10.1016/j.jagp.2021.08.002. Online ahead of print.ABSTRACTThe loss of a spouse is a common and natural life event for older adults. Nearly one of four older bereaved spouses experience prolonged grief, impaired function or chronic depression. Mechanisms underlying these and other long-term health risks are not well understood. We conducted a scoping literature review to examine the interventions and outcomes that have been studied for late-life spousal bereavement to date. We identified 22 studies of group and individual-level interventions with most studies ...
Source: The American Journal of Geriatric Psychiatry - September 8, 2021 Category: Psychiatry Authors: Jennie B Davidow Benjamin S Zide Leonard L Levin Kelsey D Biddle Juan Carlos Urizar Nancy J Donovan Source Type: research
A Scoping Review of Interventions for Spousal Bereavement in Older Adults
Am J Geriatr Psychiatry. 2021 Aug 16:S1064-7481(21)00423-1. doi: 10.1016/j.jagp.2021.08.002. Online ahead of print.ABSTRACTThe loss of a spouse is a common and natural life event for older adults. Nearly one of four older bereaved spouses experience prolonged grief, impaired function or chronic depression. Mechanisms underlying these and other long-term health risks are not well understood. We conducted a scoping literature review to examine the interventions and outcomes that have been studied for late-life spousal bereavement to date. We identified 22 studies of group and individual-level interventions with most studies ...
Source: Am J Geriatr Psychia... - September 8, 2021 Category: Geriatrics Authors: Jennie B Davidow Benjamin S Zide Leonard L Levin Kelsey D Biddle Juan Carlos Urizar Nancy J Donovan Source Type: research
A Scoping Review of Interventions for Spousal Bereavement in Older Adults
Am J Geriatr Psychiatry. 2021 Aug 16:S1064-7481(21)00423-1. doi: 10.1016/j.jagp.2021.08.002. Online ahead of print.ABSTRACTThe loss of a spouse is a common and natural life event for older adults. Nearly one of four older bereaved spouses experience prolonged grief, impaired function or chronic depression. Mechanisms underlying these and other long-term health risks are not well understood. We conducted a scoping literature review to examine the interventions and outcomes that have been studied for late-life spousal bereavement to date. We identified 22 studies of group and individual-level interventions with most studies ...
Source: The American Journal of Geriatric Psychiatry - September 8, 2021 Category: Psychiatry Authors: Jennie B Davidow Benjamin S Zide Leonard L Levin Kelsey D Biddle Juan Carlos Urizar Nancy J Donovan Source Type: research
Dose-dependent opposite effects of nortriptyline on affective-like behavior in adolescent rats: Comparison with adult rats
In conclusion, clear behavioral and neurochemical differences were observed between adolescent and adult rats in response to nortriptyline treatment. Interestingly, while nortriptyline displayed an antidepressant-like potential at the lowest dose examined in adolescence, a higher dose shifted these results towards a negative outcome, thus reinforcing the need to extreme caution when considering this treatment for our younger population.PMID:34464602 | DOI:10.1016/j.ejphar.2021.174465 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - August 31, 2021 Category: Drugs & Pharmacology Authors: Cristian Bis-Humbert Rub én García-Cabrerizo M Julia Garc ía-Fuster Source Type: research
Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis
DiscussionTricyclic antidepressants are recommended by clinical guidelines and frequently used worldwide in the treatment of major depressive disorder. There is a need for a thorough systematic review to provide the necessary background for weighing the benefits against the harms. This review will ultimately inform best practice in the treatment of major depressive disorder.Systematic review registrationPROSPEROCRD42021226161. (Source: Systematic Reviews)
Source: Systematic Reviews - August 13, 2021 Category: International Medicine & Public Health Source Type: research
Treatment of Long-term Sudden Sensorineural Hearing Loss as an Otologic Migraine Phenomenon
Objectives:
To describe a cohort of patients presenting with long-term sudden sensorineural hearing loss (SSNHL) treated with prophylactic migraine and intratympanic steroid therapy.
Methods:
Patients presenting to a neurotology clinic at least 6 weeks from SSNHL onset were included. All patients received migraine prophylactic medication (nortriptyline, topiramate, and/or verapamil) and lifestyle changes for at least 6 weeks, as well as intratympanic steroid injections, if appropriate.
Results:
Twenty-one patients (43% female) with a mean age of 64 ± 11 years who presented 9 ± 8 months (...
Source: Otology and Neurotology - July 15, 2021 Category: ENT & OMF Tags: SENSORINEURAL HEARING LOSS AND TINNITUS Source Type: research
Beneficial and harmful effects of antidepressants versus placebo, ‘active placebo’, or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and unpublished data with meta-analyses and trial sequential analyses
DiscussionAs antidepressants are commonly used to treat major depressive disorder in adults, a systematic review evaluating their beneficial and harmful effects is urgently needed. This review will inform best practice in treatment and clinical research of this highly prevalent and burdensome disorder.Systematic review registrationPROSPEROCRD42020220279 (Source: Systematic Reviews)
Source: Systematic Reviews - May 25, 2021 Category: International Medicine & Public Health Source Type: research
Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients
The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics. Apart from interindividual differences in the activity of the metabolising enzymes cytochrome P450 (CYP) 2D6 and 2C19, genetic polymorphism of the hepatic influx transporter organic cation transporter 1 (OCT1) could be contributing to interindividual variation in pharmacokinetics. Here, the impact of OCT1 genetic variation on the pharmacokinetics of amitriptyline and its active metabolite nortriptyline was studied in vitro as well as in healthy volunteers and in...
Source: Frontiers in Pharmacology - May 21, 2021 Category: Drugs & Pharmacology Source Type: research
Determination of drugs in exhumed liver and brain tissue after over 9 years of burial by liquid chromatography–tandem mass spectrometry—Part 2: Benzodiazepines, opioids, and further drugs
This paper may serve as reference for exhumations with a postmortem interval of more than 9.5 years in which an investigation of benzodiazepines, opioids, and further drugs is performed. The benzodiazepines diazepam, its metabolites, 7 ‐aminoflunitrazepam, and midazolam as well as all opioids (like fentanyl, morphine, and tramadol), and 4‐aminoantipyrine, 4‐methylaminoantipyrine, ambroxol, amitriptyline, its metabolite nortriptyline, bupivacaine, etomidate, glibenclamide, nortriptyline, its metabolite amitriptyline, pantopra zole, promethazine, propofol, rocuronium, and ropivacaine were detectable in liver and brain ...
Source: Drug Testing and Analysis - April 7, 2021 Category: Drugs & Pharmacology Authors: Katarina Bolte,
Marek Dziadosz,
Naomi Kono,
Benedikt Vennemann,
Michael Klintschar,
J örg Teske Tags: RESEARCH ARTICLE Source Type: research
