Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research

Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research

Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research

Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research

Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research

Activation of NOP receptor increases vulnerability to stress: role of glucocorticoids and CRF signaling
ConclusionsPresent findings suggest that NOP agonists increase vulnerability to depression by hyperactivating the HPA axis and then increasing stress circulating hormones and CRF1 receptor signaling. (Source: Psychopharmacology)
Source: Psychopharmacology - January 25, 2024 Category: Psychiatry Source Type: research

Comparing the efficacy of duloxetine and nortriptyline in alleviating the symptoms of functional dyspepsia – a randomized clinical trial
ConclusionWhile both medications demonstrated efficacy, Nortriptyline appeared to be superior in symptom reduction. Duloxetine exhibited more advantages compared to Nortriptyline in addressing anxiety and depression and enhancing the overall quality of life. Also, Duloxetine may have a noteworthy impact, contributing to a 20% reduction in FD symptoms by lowering anxiety levels.Clinical trial registrationhttps://en.irct.ir/trial/65512. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - January 16, 2024 Category: Psychiatry Source Type: research

Clinical Trial: Efficacy of Mosapride Controlled-release and Nortriptyline in Patients With Functional Dyspepsia: A Multicenter, Double-placebo, Double-blinded, Randomized Controlled, Parallel Clinical Study
CONCLUSION: Mosapride CR and nortriptyline showed similar efficacy in patients with FD regardless of the subtype. Both treatments could be equally helpful for improving quality of life and psychological well-being while also relieving dyspepsia.PMID:38173162 | DOI:10.5056/jnm23147 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Chung Hyun Tae Ra Ri Cha Jung-Hwan Oh Tae-Guen Gweon Jong Kyu Park Ki Bae Bang Kyung Ho Song Cheal Wung Huh Ju Yup Lee Cheol Min Shin Jong Wook Kim Young Hoon Youn Joong Goo Kwon Functional Dyspepsia Research Group under the Korean Society of Neurogastroe Source Type: research

Clinical Trial: Efficacy of Mosapride Controlled-release and Nortriptyline in Patients With Functional Dyspepsia: A Multicenter, Double-placebo, Double-blinded, Randomized Controlled, Parallel Clinical Study
CONCLUSION: Mosapride CR and nortriptyline showed similar efficacy in patients with FD regardless of the subtype. Both treatments could be equally helpful for improving quality of life and psychological well-being while also relieving dyspepsia.PMID:38173162 | PMC:PMC10774802 | DOI:10.5056/jnm23147 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Chung Hyun Tae Ra Ri Cha Jung-Hwan Oh Tae-Guen Gweon Jong Kyu Park Ki Bae Bang Kyung Ho Song Cheal Wung Huh Ju Yup Lee Cheol Min Shin Jong Wook Kim Young Hoon Youn Joong Goo Kwon Functional Dyspepsia Research Group under the Korean Society of Neurogastroe Source Type: research

Adverse drug events associated with nortriptyline compared with paroxetine and alternative medications in an older adult population: a retrospective cohort study in Southern California
Conclusions Compared with therapeutic alternatives, nortriptyline was found to represent a lower risk for falls, fractures and syncope, versus comparator medications, except for a few instances that had equivalent risk. The risk for these adverse events from paroxetine was comparable to the alternative medications. (Source: BMJ Open)
Source: BMJ Open - December 28, 2023 Category: General Medicine Authors: George, M. M., Deamer, R. L., Do, D. Tags: Open access, Geriatric medicine Source Type: research

Smoking cessation and its significant role in the Indian scenario
Monaldi Arch Chest Dis. 2023 Dec 4. doi: 10.4081/monaldi.2023.2814. Online ahead of print.ABSTRACTGiven the increased health dangers of tobacco use, particularly in developing countries, smoking cessation intervention is crucially important. The aim of this study is to determine and assess the effectiveness of a comprehensive smoking cessation intervention program, incorporating behavior modification, counseling, and pharmacologic treatments, in the context of the Indian scenario. The process of initiating smoking or tobacco cessation begins with the evaluation of the distinct stages that smokers undergo as part of their j...
Source: Monaldi Archives for Chest Disease - December 5, 2023 Category: Respiratory Medicine Authors: Raj Kumar Manoj Kumar Sukriti Raj Dileep Kumar Arisham Anil Kumar Mavi Kamal Singh Source Type: research