Dimensions of temperament and character as predictors of antidepressant discontinuation, response and adverse reactions during treatment with nortriptyline and escitalopram

CONCLUSIONS: This study, representing the largest investigation between several personality traits and response to two different antidepressants, suggests that correlations between personality traits and antidepressant treatment response may be confounded by differential rates of discontinuation. Future trials on personality in the treatment of depression need to consider this interdependency and study whether interventions aiming at improving compliance for some personality types may improve response to antidepressants.PMID:34763734 | DOI:10.1017/S003329172100444X

Source: Psychological Medicine - November 12, 2021 Category: Psychiatry Authors: Ole K öhler-Forsberg Robert Keers Rudolf Uher Joanna Hauser Wolfgang Maier Marcella Rietschel Peter McGuffin Anne E Farmer Katherine J Aitchison Ole Mors Source Type: research