Molnupiravir inhibits human norovirus and rotavirus replication in 3D human intestinal enteroids
Antiviral Res. 2024 Feb 17:105839. doi: 10.1016/j.antiviral.2024.105839. Online ahead of print.ABSTRACTHuman norovirus (HuNoV) and human rotavirus (HRV) are the leading causes of gastrointestinal diarrhea. There are no approved antivirals and rotavirus vaccines are insufficient to cease HRV associated mortality. Furthermore, treatment of chronically infected immunocompromised patients is limited to off-label compassionate use of repurposed antivirals with limited efficacy, highlighting the urgent need of potent and specific antivirals for HuNoV and HRV. Recently, a major breakthrough in the in vitro cultivation of HuNoV an...
Source: Antiviral Research - February 19, 2024 Category: Virology Authors: Nanci Santos-Ferreira Jana Van Dycke Winston Chiu Johan Neyts Jelle Matthijnssens Joana Rocha-Pereira Source Type: research
Molnupiravir inhibits human norovirus and rotavirus replication in 3D human intestinal enteroids
Antiviral Res. 2024 Feb 17:105839. doi: 10.1016/j.antiviral.2024.105839. Online ahead of print.ABSTRACTHuman norovirus (HuNoV) and human rotavirus (HRV) are the leading causes of gastrointestinal diarrhea. There are no approved antivirals and rotavirus vaccines are insufficient to cease HRV associated mortality. Furthermore, treatment of chronically infected immunocompromised patients is limited to off-label compassionate use of repurposed antivirals with limited efficacy, highlighting the urgent need of potent and specific antivirals for HuNoV and HRV. Recently, a major breakthrough in the in vitro cultivation of HuNoV an...
Source: Antiviral Research - February 19, 2024 Category: Virology Authors: Nanci Santos-Ferreira Jana Van Dycke Winston Chiu Johan Neyts Jelle Matthijnssens Joana Rocha-Pereira Source Type: research
Molnupiravir inhibits human norovirus and rotavirus replication in 3D human intestinal enteroids
Antiviral Res. 2024 Feb 17;223:105839. doi: 10.1016/j.antiviral.2024.105839. Online ahead of print.ABSTRACTHuman norovirus (HuNoV) and human rotavirus (HRV) are the leading causes of gastrointestinal diarrhea. There are no approved antivirals and rotavirus vaccines are insufficient to cease HRV associated mortality. Furthermore, treatment of chronically infected immunocompromised patients is limited to off-label compassionate use of repurposed antivirals with limited efficacy, highlighting the urgent need of potent and specific antivirals for HuNoV and HRV. Recently, a major breakthrough in the in vitro cultivation of HuNo...
Source: Antiviral Research - February 19, 2024 Category: Virology Authors: Nanci Santos-Ferreira Jana Van Dycke Winston Chiu Johan Neyts Jelle Matthijnssens Joana Rocha-Pereira Source Type: research
Transmission of Viruses from Restroom Use: A Quantitative Microbial Risk Assessment
In this study, we apply quantitative microbial risk assessment to quantify the risk of viral transmission by contaminated restroom fomites. We estimate risk from high-touch fomite surfaces (entrance/exit door, toilet seat) for three viruses of interest (SARS-CoV-2, adenovirus, norovirus) through eight exposure scenarios involving differing user behaviors, and the use of hand sanitizer following each scenario. We assessed the impacts of several sequences of fomite contacts in the restroom, reflecting the variability of human behavior, on infection risks for these viruses. Touching of the toilet seat was assumed to model adj...
Source: Food and Environmental Virology - February 19, 2024 Category: Virology Source Type: research
Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant
CONCLUSIONS: Our data show that more than half of pediatric patients who were admitted for HSCT were colonized with various gastrointestinal pathogens, and more than one-third of these pathogens were associated with post-transplantation diarrhea. In addition, the FilmArray GI panel can increase the detection rate of diarrheal pathogens in pediatric HSCT patients, but the panel needs to be optimized for pathogen species, and further studies assessing its clinical impact and cost-effectiveness in this specific patient population are also needed.PMID:38367140 | DOI:10.1007/s12519-023-00776-w (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - February 17, 2024 Category: Pediatrics Authors: Yue Tao Cheng-Juan Luo Bing-Hua Zhang Xin-Yan Shen Rui-Ke Zhao Bei-Ying Ma Nan Shen Chang-Ying Luo Jian-Min Wang Yi-Jun Xia Li Xie Jing Chen Xi Mo Source Type: research
Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant
CONCLUSIONS: Our data show that more than half of pediatric patients who were admitted for HSCT were colonized with various gastrointestinal pathogens, and more than one-third of these pathogens were associated with post-transplantation diarrhea. In addition, the FilmArray GI panel can increase the detection rate of diarrheal pathogens in pediatric HSCT patients, but the panel needs to be optimized for pathogen species, and further studies assessing its clinical impact and cost-effectiveness in this specific patient population are also needed.PMID:38367140 | DOI:10.1007/s12519-023-00776-w (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - February 17, 2024 Category: Pediatrics Authors: Yue Tao Cheng-Juan Luo Bing-Hua Zhang Xin-Yan Shen Rui-Ke Zhao Bei-Ying Ma Nan Shen Chang-Ying Luo Jian-Min Wang Yi-Jun Xia Li Xie Jing Chen Xi Mo Source Type: research
Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant
CONCLUSIONS: Our data show that more than half of pediatric patients who were admitted for HSCT were colonized with various gastrointestinal pathogens, and more than one-third of these pathogens were associated with post-transplantation diarrhea. In addition, the FilmArray GI panel can increase the detection rate of diarrheal pathogens in pediatric HSCT patients, but the panel needs to be optimized for pathogen species, and further studies assessing its clinical impact and cost-effectiveness in this specific patient population are also needed.PMID:38367140 | DOI:10.1007/s12519-023-00776-w (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - February 17, 2024 Category: Pediatrics Authors: Yue Tao Cheng-Juan Luo Bing-Hua Zhang Xin-Yan Shen Rui-Ke Zhao Bei-Ying Ma Nan Shen Chang-Ying Luo Jian-Min Wang Yi-Jun Xia Li Xie Jing Chen Xi Mo Source Type: research
Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant
CONCLUSIONS: Our data show that more than half of pediatric patients who were admitted for HSCT were colonized with various gastrointestinal pathogens, and more than one-third of these pathogens were associated with post-transplantation diarrhea. In addition, the FilmArray GI panel can increase the detection rate of diarrheal pathogens in pediatric HSCT patients, but the panel needs to be optimized for pathogen species, and further studies assessing its clinical impact and cost-effectiveness in this specific patient population are also needed.PMID:38367140 | DOI:10.1007/s12519-023-00776-w (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - February 17, 2024 Category: Pediatrics Authors: Yue Tao Cheng-Juan Luo Bing-Hua Zhang Xin-Yan Shen Rui-Ke Zhao Bei-Ying Ma Nan Shen Chang-Ying Luo Jian-Min Wang Yi-Jun Xia Li Xie Jing Chen Xi Mo Source Type: research
Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant
CONCLUSIONS: Our data show that more than half of pediatric patients who were admitted for HSCT were colonized with various gastrointestinal pathogens, and more than one-third of these pathogens were associated with post-transplantation diarrhea. In addition, the FilmArray GI panel can increase the detection rate of diarrheal pathogens in pediatric HSCT patients, but the panel needs to be optimized for pathogen species, and further studies assessing its clinical impact and cost-effectiveness in this specific patient population are also needed.PMID:38367140 | DOI:10.1007/s12519-023-00776-w (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - February 17, 2024 Category: Pediatrics Authors: Yue Tao Cheng-Juan Luo Bing-Hua Zhang Xin-Yan Shen Rui-Ke Zhao Bei-Ying Ma Nan Shen Chang-Ying Luo Jian-Min Wang Yi-Jun Xia Li Xie Jing Chen Xi Mo Source Type: research
Development of real-time RT-PCR systems for detection and quantitation of bovine enteric viral pathogens
In conclusion, real time PCR developed for these viruses are highly specific and sensitive technique for the detection of diarrheic viral pathogens of cattle and buffalo.PMID:38347693 | DOI:10.1080/10495398.2023.2182314 (Source: Animal Biotechnology)
Source: Animal Biotechnology - February 13, 2024 Category: Biotechnology Authors: Monika Punia Sushila Maan Kanisht Batra Deepika Chaudhary Bhanita Devi Aman Kumar Suresh Kumar Gahlawat Narender Singh Maan Source Type: research
Development of real-time RT-PCR systems for detection and quantitation of bovine enteric viral pathogens
In conclusion, real time PCR developed for these viruses are highly specific and sensitive technique for the detection of diarrheic viral pathogens of cattle and buffalo.PMID:38347693 | DOI:10.1080/10495398.2023.2182314 (Source: Animal Biotechnology)
Source: Animal Biotechnology - February 13, 2024 Category: Biotechnology Authors: Monika Punia Sushila Maan Kanisht Batra Deepika Chaudhary Bhanita Devi Aman Kumar Suresh Kumar Gahlawat Narender Singh Maan Source Type: research
Development of real-time RT-PCR systems for detection and quantitation of bovine enteric viral pathogens
In conclusion, real time PCR developed for these viruses are highly specific and sensitive technique for the detection of diarrheic viral pathogens of cattle and buffalo.PMID:38347693 | DOI:10.1080/10495398.2023.2182314 (Source: Animal Biotechnology)
Source: Animal Biotechnology - February 13, 2024 Category: Biotechnology Authors: Monika Punia Sushila Maan Kanisht Batra Deepika Chaudhary Bhanita Devi Aman Kumar Suresh Kumar Gahlawat Narender Singh Maan Source Type: research
Development of real-time RT-PCR systems for detection and quantitation of bovine enteric viral pathogens
In conclusion, real time PCR developed for these viruses are highly specific and sensitive technique for the detection of diarrheic viral pathogens of cattle and buffalo.PMID:38347693 | DOI:10.1080/10495398.2023.2182314 (Source: Animal Biotechnology)
Source: Animal Biotechnology - February 13, 2024 Category: Biotechnology Authors: Monika Punia Sushila Maan Kanisht Batra Deepika Chaudhary Bhanita Devi Aman Kumar Suresh Kumar Gahlawat Narender Singh Maan Source Type: research
Development of real-time RT-PCR systems for detection and quantitation of bovine enteric viral pathogens
In conclusion, real time PCR developed for these viruses are highly specific and sensitive technique for the detection of diarrheic viral pathogens of cattle and buffalo.PMID:38347693 | DOI:10.1080/10495398.2023.2182314 (Source: Animal Biotechnology)
Source: Animal Biotechnology - February 13, 2024 Category: Biotechnology Authors: Monika Punia Sushila Maan Kanisht Batra Deepika Chaudhary Bhanita Devi Aman Kumar Suresh Kumar Gahlawat Narender Singh Maan Source Type: research
Development of real-time RT-PCR systems for detection and quantitation of bovine enteric viral pathogens
In conclusion, real time PCR developed for these viruses are highly specific and sensitive technique for the detection of diarrheic viral pathogens of cattle and buffalo.PMID:38347693 | DOI:10.1080/10495398.2023.2182314 (Source: Animal Biotechnology)
Source: Animal Biotechnology - February 13, 2024 Category: Biotechnology Authors: Monika Punia Sushila Maan Kanisht Batra Deepika Chaudhary Bhanita Devi Aman Kumar Suresh Kumar Gahlawat Narender Singh Maan Source Type: research
