The multicenter real-world report of the efficacies of 14-day esomeprazole-based and rabeprazole-based high-dose dual therapy in first-line Helicobacter pylori eradication in Taiwan
CONCLUSIONS: Esomeprazole-based HDDT achieved over 90% eradication rates but rabeprazole-based HDDT, which failed.PMID:38461114 | DOI:10.1016/j.jmii.2024.02.009 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - March 9, 2024 Category: Microbiology Authors: Wei-Chen Tai I-Ting Wu Hsin-Ming Wang Pao-Yuan Huang Chih-Chien Yao Cheng-Kun Wu Shih-Cheng Yang Chih-Ming Liang Pin-I Hsu Seng-Kee Chuah Source Type: research
Sodium citrate buffer improves pazopanib solubility and absorption in gastric acid-suppressed rat model
Drug Metab Pharmacokinet. 2024 Jan 3;55:100995. doi: 10.1016/j.dmpk.2024.100995. Online ahead of print.ABSTRACTPazopanib exhibits pH-dependent solubility and its absorption depends primarily on the stomach pH. Significant decrease of pazopanib absorption by coadministration with proton pump inhibitors in clinical situation need to be overcome. Thus, the purpose of this study is firstly to investigate the effect of acidic beverages and sodium citrate buffer on the solubility of pazopanib and secondly to examine the effect of sodium citrate buffer on pazopanib absorption in a rat model with esomeprazole-mediated gastric acid...
Source: Drug Metabolism and Pharmacokinetics - March 6, 2024 Category: Drugs & Pharmacology Authors: Huda Jassim Muhammad Tsutomu Shimada Arimi Fujita Yoshimichi Sai Source Type: research
Severe Anemia from Multiple Gastric Hyperplastic Polyps in a Hemodialysis Patient after Long-term Use of a Proton-pump Inhibitor
Intern Med. 2024;63(5):649-657. doi: 10.2169/internalmedicine.2091-23.ABSTRACTA 90-year-old man on maintenance hemodialysis was admitted due to severe symptomatic anemia. Biopsies under esophagogastroduodenoscopy demonstrated that the cause of anemia was intermittent blood oozing from multiple gastric hyperplastic polyps. Even after successful eradication of Helicobacter pylori, he showed hypergastrinemia (480 pg/mL) owing to esomeprazole (proton-pump inhibitor) therapy for the past 4.5 years to treat reflux esophagitis. Seven months after we switched esomeprazole to famotidine (H2-receptor antagonist), those gastric polyp...
Source: Internal Medicine - March 3, 2024 Category: Internal Medicine Authors: Shiyo Ikeda Toshiya Takahashi Toshitsugu Tandoh Kaori Ushiyama Yujiro Kida Source Type: research
The Effect of Tegoprazan on the Treatment of Endoscopic Resection-Induced Artificial Ulcers: A Multicenter, Randomized, Active-Controlled Study
CONCLUSIONS: : Tegoprazan showed similar effects on post-ESD artificial ulcer healing in comparison with esomeprazole.PMID:38384180 | DOI:10.5009/gnl230242 (Source: Gut and Liver)
Source: Gut and Liver - February 22, 2024 Category: Gastroenterology Authors: Byung-Wook Kim Jong Jae Park Hee Seok Moon Wan Sik Lee Ki-Nam Shim Gwang Ho Baik Yun Jeong Lim Hang Lak Lee Young Hoon Youn Jun Chul Park In-Kyung Sung Hyunsoo Chung Jeong Seop Moon Gwang Ha Kim Su Jin Hong Hyuk Soon Choi Source Type: research
The Relevance of Integrating CYP2C19 Phenoconversion Effects into
Clinical Pharmacogenetics
Discussion PC of CYP2C19 changes phenotypes but does not improve
correlations with serum concentrations. However, only a limited number of
patients received perturbators of CYP2C19. Studies with large numbers of
patients are still lacking, and thus, it cannot be decided if there are minor
differences and which method of correction to use. For the time being, PC is
relevant in individual patients treated with CYP2C19-affecting drugs, for
example, esomeprazole. To ensure adequate serum concentrations in these
patients, this study suggests the use of therap...
Source: Pharmacopsychiatry - February 14, 2024 Category: Psychiatry Authors: Scherf-Clavel, Maike Weber, Heike Unterecker, Stefan Frantz, Amelie Eckert, Andreas Reif, Andreas Deckert, J ürgen Hahn, Martina Tags: Original Paper Source Type: research
Relationships of Proton Pump Inhibitor-Induced Renal Injury with CYP2C19 Polymorphism: A Retrospective Cohort Study
In conclusion, this retrospective study showed that CYP2C19 metabolizer status was associated with the time to a 30% eGFR decrease in patients treated with lansoprazole, but not with esomeprazole, rabeprazole, or vonoprazan.PMID:38258325 | DOI:10.1002/cpt.3183 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - January 23, 2024 Category: Drugs & Pharmacology Authors: Rika Fukui Satoshi Noda Yoshito Ikeda Yuichi Sawayama Tomohiro Terada Yoshihisa Nakagawa Shin-Ya Morita Source Type: research
