The Effect of Tegoprazan on the Treatment of Endoscopic Resection-Induced Artificial Ulcers: A Multicenter, Randomized, Active-Controlled Study
CONCLUSIONS: : Tegoprazan showed similar effects on post-ESD artificial ulcer healing in comparison with esomeprazole.PMID:38384180 | DOI:10.5009/gnl230242 (Source: Gut and Liver)
Source: Gut and Liver - February 22, 2024 Category: Gastroenterology Authors: Byung-Wook Kim Jong Jae Park Hee Seok Moon Wan Sik Lee Ki-Nam Shim Gwang Ho Baik Yun Jeong Lim Hang Lak Lee Young Hoon Youn Jun Chul Park In-Kyung Sung Hyunsoo Chung Jeong Seop Moon Gwang Ha Kim Su Jin Hong Hyuk Soon Choi Source Type: research

The Relevance of Integrating CYP2C19 Phenoconversion Effects into Clinical Pharmacogenetics
Discussion PC of CYP2C19 changes phenotypes but does not improve correlations with serum concentrations. However, only a limited number of patients received perturbators of CYP2C19. Studies with large numbers of patients are still lacking, and thus, it cannot be decided if there are minor differences and which method of correction to use. For the time being, PC is relevant in individual patients treated with CYP2C19-affecting drugs, for example, esomeprazole. To ensure adequate serum concentrations in these patients, this study suggests the use of therap...
Source: Pharmacopsychiatry - February 14, 2024 Category: Psychiatry Authors: Scherf-Clavel, Maike Weber, Heike Unterecker, Stefan Frantz, Amelie Eckert, Andreas Reif, Andreas Deckert, J ürgen Hahn, Martina Tags: Original Paper Source Type: research

Relationships of Proton Pump Inhibitor-Induced Renal Injury with CYP2C19 Polymorphism: A Retrospective Cohort Study
In conclusion, this retrospective study showed that CYP2C19 metabolizer status was associated with the time to a 30% eGFR decrease in patients treated with lansoprazole, but not with esomeprazole, rabeprazole, or vonoprazan.PMID:38258325 | DOI:10.1002/cpt.3183 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - January 23, 2024 Category: Drugs & Pharmacology Authors: Rika Fukui Satoshi Noda Yoshito Ikeda Yuichi Sawayama Tomohiro Terada Yoshihisa Nakagawa Shin-Ya Morita Source Type: research

Trend analysis of proton pump inhibitor consumption and expenditure: The real-world evidence
ConclusionWithin this analysis, we provide an illustrative representation of the prescribing trends for PPIs within a European context. Omeprazole, rabeprazole and lansoprazole appear to be the cheapest drugs compared to pantoprazole and esomeprazole. However, the results show that the most widely used PPIs, despite their therapeutic equivalence, are precisely the high-cost ones, thus generating higher expenditure for central governments.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 17, 2024 Category: Gastroenterology Source Type: research

Clinical Study on the Eradication of Helicobacter pylori by Vonoprazan Combined with Amoxicillin for 10 ‐Day Dual Therapy
In this study,H. pylori patients (426) were enrolled and randomized into 3 groups: an EA14 group (20  mg of esomeprazole qid and 1000 mg of amoxicillin tid for 14 days), a VA14 group (20 mg of vonoprazan bid and 750 mg of amoxicillin qid for 14 days), and a VA10 group (20 mg of vonoprazan bid and 1000 mg of amoxicillin tid for 10 days). Key outcomes encompassed theH. pylori eradication rate, patient adverse effects, and compliance. In the EA14, VA14, and VA10 groups,H. pylori eradication rates were 89.4%, 90.1%, and 88.7% in intention-to-treat analysis, and 94.2%, 94.4%, and 94.6% in per-protocol analysis, respectiv...
Source: Clinical Pharmacology in Drug Development - January 11, 2024 Category: Drugs & Pharmacology Authors: Kunfeng Yan, Xiaorong Dai, Zhenxing Li, Weiwei Rong, Lei Chen, Xinxin Diao Tags: Original Article Source Type: research

Prescribing Patterns of Proton Pump Inhibitors in Germany: A Retrospective Study Including 472  146 Patients
This study highlights that discrepancies exist between clinical guidelines and real-life prescribing practices of PPIs in Germany. Particular attention should be given to the incidence of patients being prescribed high-dose or long-duration PPI with mild indications. These findings are particularly apt considering the publication (March 2023) of new guidelines on the "management of gastroesophageal reflux disease and eosinophilic esophagitis," by the DGVS.PMID:38142444 | DOI:10.1177/21501319231221002 (Source: Primary Care)
Source: Primary Care - December 24, 2023 Category: Primary Care Authors: Kate Plehhova Monika Haering Joshua Wray Cathal Coyle Eduardo Ib áñez Karel Kostev Source Type: research

Prescribing Patterns of Proton Pump Inhibitors in Germany: A Retrospective Study Including 472  146 Patients
This study highlights that discrepancies exist between clinical guidelines and real-life prescribing practices of PPIs in Germany. Particular attention should be given to the incidence of patients being prescribed high-dose or long-duration PPI with mild indications. These findings are particularly apt considering the publication (March 2023) of new guidelines on the "management of gastroesophageal reflux disease and eosinophilic esophagitis," by the DGVS.PMID:38142444 | PMC:PMC10749518 | DOI:10.1177/21501319231221002 (Source: Primary Care)
Source: Primary Care - December 24, 2023 Category: Primary Care Authors: Kate Plehhova Monika Haering Joshua Wray Cathal Coyle Eduardo Ib áñez Karel Kostev Source Type: research

Efficacy and safety of HIP1601 (dual delayed-release esomeprazole) 40 mg in erosive esophagitis compared to HGP1705 (delayed-release esomeprazole) 40 mg: a multicenter, randomized, double-blind, non-inferiority study
This study aime... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - December 18, 2023 Category: Gastroenterology Authors: Hyun Lim, Jong Kyu Park, Hyunsoo Chung, Si Hyung Lee, Jae Myung Park, Jung Ho Park, Gwang Ha Kim, Sung Kwan Shin, Su Jin Hong, Kwang Jae Lee, Moo In Park, Hye-Kyung Jung, Hyun-Soo Kim, Jae Kyu Sung, Seong Woo Jeon, Suck Chei Choi & hellip; Tags: Research Source Type: research

Acid ‐suppressive drugs: A systematic review and network meta‐analysis of their nocturnal acid‐inhibitory effect
ConclusionsThis is the first study to compare the effect of ASDs on inhibiting nocturnal acid breakthrough. Overall, in terms of nocturnal acid-inhibitory effect, vonoprazan and tegoprazan had an advantage against other regimens including H2RAs, isomer PPIs, traditional PPIs, AHB, and new PPIs. Even in some subgroups, such as language classification (English), types of study design (crossover-RCT), age ( ≤40 years), BMI (18.5-24.9 kg/m2), continent (Asia and North America), disease status (health), the duration of therapy (2  weeks), and time of administration (at daytime or at night-time), the nocturnal acid-inhibit...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 5, 2023 Category: Drugs & Pharmacology Authors: Shupeng Zou, Mengling Ouyang, Qian Cheng, Xuan Shi, Minghui Sun Tags: RESEARCH ARTICLE Source Type: research

Assessing the hypolipidemic and gastro-liver protective activity of herbal combination with emphasis on PPI amid selected multiple antihypertensive drug combination in experimental animal models
CONCLUSIONS: CThis investigation reported that antihypertensive drugs did not produce gastrointestinal (GI) toxicity, and the morphological structure of the organ was not changed. So, it could be concluded that the herbal combination used in this experiment has a promising role in controlling lipid profile, liver function, and antiulcer effects. Moreover, multiple drug therapy for hypertension does not cause any harm to the stomach. Further investigations might be carried out on a larger scale to make these statements more valid.PMID:38039033 | DOI:10.26355/eurrev_202311_34471 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 1, 2023 Category: Drugs & Pharmacology Authors: R P Monisa A K Azad I Rahma J T Israt A Shopnil A K Ayaz U H Taqweem T Aziz A Metab H A Thamer F A Abdullah Source Type: research

Assessing the hypolipidemic and gastro-liver protective activity of herbal combination with emphasis on PPI amid selected multiple antihypertensive drug combination in experimental animal models
CONCLUSIONS: CThis investigation reported that antihypertensive drugs did not produce gastrointestinal (GI) toxicity, and the morphological structure of the organ was not changed. So, it could be concluded that the herbal combination used in this experiment has a promising role in controlling lipid profile, liver function, and antiulcer effects. Moreover, multiple drug therapy for hypertension does not cause any harm to the stomach. Further investigations might be carried out on a larger scale to make these statements more valid.PMID:38039033 | DOI:10.26355/eurrev_202311_34471 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 1, 2023 Category: Drugs & Pharmacology Authors: R P Monisa A K Azad I Rahma J T Israt A Shopnil A K Ayaz U H Taqweem T Aziz A Metab H A Thamer F A Abdullah Source Type: research