Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor: A Pilot Study on Comparable Efficacy in the Treatment of Gastroesophageal Reflux-Related Cough
In conclusion, vonoprazan may be comparable to esomeprazole in cough symptom relief in GERC during the 2-month treatment period, but possibly provides better gains on classic reflux symptoms and quality-of-life. The long-term efficacy of P-CABs on GERC may be worth further exploration. Trial Registration: Chinese Clinical Trial Registry Identifier: ChiCTR2200067089.PMID:38528386 | DOI:10.4168/aair.2024.16.2.191 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 26, 2024 Category: Allergy & Immunology Authors: Shuxin Zhong Mingyu Zhong Liman Fang Haopeng Zhi Xiaolong Ji Kailun Tang Chen Zhan Xu Shi Mo Xian Wanjun Wang Jing Li Wei Luo Kefang Lai Ruchong Chen Source Type: research

Anti-fungal effects of novel N-(tert-butyl)-2-(pyridin-2-yl)imidazo[1,2-a]pyridin-3-amine derivative and it's in-vitro, in-silico, and mode of action against Candida spp
In this study, two newly synthesized imidazo[1,2-a]pyridine derivative (Probe I and Probe II) molecules were investigated for its antimicrobial potency against of a panel of bacterial (Gram-positive and Gram-negative bacteria) and fungal pathogens. Among the different types of pathogens, we found that Probe II showed excellent antifungal activity against fungal pathogens, based on the preliminary screening the potent molecule further investigated against multidrug-resistance Candida sp. (n = 10) and compared with commercial molecules. In addition, in-silico molecular docking, its dynamics, absorption, distribution, metabol...
Source: Archives of Microbiology - March 21, 2024 Category: Microbiology Authors: Manivannan Nandhagopal Ramanjaneyulu Mala Kanagasabai Somarathinam Divya Dhakshinamurthy Mathivanan Narayanasamy Priyadharshni Vijayan Manimuthu Mani Shankar Source Type: research

Anti-fungal effects of novel N-(tert-butyl)-2-(pyridin-2-yl)imidazo[1,2-a]pyridin-3-amine derivative and it's in-vitro, in-silico, and mode of action against Candida spp
In this study, two newly synthesized imidazo[1,2-a]pyridine derivative (Probe I and Probe II) molecules were investigated for its antimicrobial potency against of a panel of bacterial (Gram-positive and Gram-negative bacteria) and fungal pathogens. Among the different types of pathogens, we found that Probe II showed excellent antifungal activity against fungal pathogens, based on the preliminary screening the potent molecule further investigated against multidrug-resistance Candida sp. (n = 10) and compared with commercial molecules. In addition, in-silico molecular docking, its dynamics, absorption, distribution, metabol...
Source: Archives of Microbiology - March 21, 2024 Category: Microbiology Authors: Manivannan Nandhagopal Ramanjaneyulu Mala Kanagasabai Somarathinam Divya Dhakshinamurthy Mathivanan Narayanasamy Priyadharshni Vijayan Manimuthu Mani Shankar Source Type: research

Anodic oxidation of esomeprazole in water by carbon coated titanium (C/Ti) electrode: Optimization and degradation analysis
Anodic oxidation of Esomeprazole in water. AbstractEsomeprazole (ESO) is one of the proton pump inhibitors (PPIs) that is commonly used to treat extreme acidity and gastrointestinal irritation. Since it is used at a high rate, it is now classified as a pollutant of emerging concern (CEC). ESO gravely jeopardizes the health of living beings because it persists in water and wastewater sources even after standard treatment. Studies on the effective removal of PPIs, especially ESO, are scarce. In the current study, esomeprazole is disintegrated in water using electrochemical oxidation (EO). Titanium cathode with sodium sulfate...
Source: Environmental Quality Management - March 20, 2024 Category: Environmental Health Authors: Salman Farissi, Harikrishnan Palasseri, Utukuri Gopi, Gara Ajith, Anbazhagi Muthukumar, Muthukumar Muthuchamy Tags: RESEARCH ARTICLE Source Type: research

The multicenter real-world report of the efficacies of 14-day esomeprazole-based and rabeprazole-based high-dose dual therapy in first-line Helicobacter pylori eradication in Taiwan
CONCLUSIONS: Esomeprazole-based HDDT achieved over 90% eradication rates but rabeprazole-based HDDT, which failed.PMID:38461114 | DOI:10.1016/j.jmii.2024.02.009 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - March 9, 2024 Category: Microbiology Authors: Wei-Chen Tai I-Ting Wu Hsin-Ming Wang Pao-Yuan Huang Chih-Chien Yao Cheng-Kun Wu Shih-Cheng Yang Chih-Ming Liang Pin-I Hsu Seng-Kee Chuah Source Type: research

The multicenter real-world report of the efficacies of 14-day esomeprazole-based and rabeprazole-based high-dose dual therapy in first-line Helicobacter pylori eradication in Taiwan
CONCLUSIONS: Esomeprazole-based HDDT achieved over 90% eradication rates but rabeprazole-based HDDT, which failed.PMID:38461114 | DOI:10.1016/j.jmii.2024.02.009 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - March 9, 2024 Category: Microbiology Authors: Wei-Chen Tai I-Ting Wu Hsin-Ming Wang Pao-Yuan Huang Chih-Chien Yao Cheng-Kun Wu Shih-Cheng Yang Chih-Ming Liang Pin-I Hsu Seng-Kee Chuah Source Type: research

The multicenter real-world report of the efficacies of 14-day esomeprazole-based and rabeprazole-based high-dose dual therapy in first-line Helicobacter pylori eradication in Taiwan
CONCLUSIONS: Esomeprazole-based HDDT achieved over 90% eradication rates but rabeprazole-based HDDT, which failed.PMID:38461114 | DOI:10.1016/j.jmii.2024.02.009 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - March 9, 2024 Category: Microbiology Authors: Wei-Chen Tai I-Ting Wu Hsin-Ming Wang Pao-Yuan Huang Chih-Chien Yao Cheng-Kun Wu Shih-Cheng Yang Chih-Ming Liang Pin-I Hsu Seng-Kee Chuah Source Type: research

The multicenter real-world report of the efficacies of 14-day esomeprazole-based and rabeprazole-based high-dose dual therapy in first-line Helicobacter pylori eradication in Taiwan
CONCLUSIONS: Esomeprazole-based HDDT achieved over 90% eradication rates but rabeprazole-based HDDT, which failed.PMID:38461114 | DOI:10.1016/j.jmii.2024.02.009 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - March 9, 2024 Category: Microbiology Authors: Wei-Chen Tai I-Ting Wu Hsin-Ming Wang Pao-Yuan Huang Chih-Chien Yao Cheng-Kun Wu Shih-Cheng Yang Chih-Ming Liang Pin-I Hsu Seng-Kee Chuah Source Type: research

Sodium citrate buffer improves pazopanib solubility and absorption in gastric acid-suppressed rat model
Drug Metab Pharmacokinet. 2024 Jan 3;55:100995. doi: 10.1016/j.dmpk.2024.100995. Online ahead of print.ABSTRACTPazopanib exhibits pH-dependent solubility and its absorption depends primarily on the stomach pH. Significant decrease of pazopanib absorption by coadministration with proton pump inhibitors in clinical situation need to be overcome. Thus, the purpose of this study is firstly to investigate the effect of acidic beverages and sodium citrate buffer on the solubility of pazopanib and secondly to examine the effect of sodium citrate buffer on pazopanib absorption in a rat model with esomeprazole-mediated gastric acid...
Source: Drug Metabolism and Pharmacokinetics - March 6, 2024 Category: Drugs & Pharmacology Authors: Huda Jassim Muhammad Tsutomu Shimada Arimi Fujita Yoshimichi Sai Source Type: research

Severe Anemia from Multiple Gastric Hyperplastic Polyps in a Hemodialysis Patient after Long-term Use of a Proton-pump Inhibitor
Intern Med. 2024;63(5):649-657. doi: 10.2169/internalmedicine.2091-23.ABSTRACTA 90-year-old man on maintenance hemodialysis was admitted due to severe symptomatic anemia. Biopsies under esophagogastroduodenoscopy demonstrated that the cause of anemia was intermittent blood oozing from multiple gastric hyperplastic polyps. Even after successful eradication of Helicobacter pylori, he showed hypergastrinemia (480 pg/mL) owing to esomeprazole (proton-pump inhibitor) therapy for the past 4.5 years to treat reflux esophagitis. Seven months after we switched esomeprazole to famotidine (H2-receptor antagonist), those gastric polyp...
Source: Internal Medicine - March 3, 2024 Category: Internal Medicine Authors: Shiyo Ikeda Toshiya Takahashi Toshitsugu Tandoh Kaori Ushiyama Yujiro Kida Source Type: research