Evaluation of CYP2C19-Mediated Pharmacokinetic Drug Interaction of Tegoprazan, Compared with Vonoprazan or Esomeprazole
ConclusionTegoprazan, unlike vonoprazan and esomeprazole, exhibited negligible CYP2C19-mediated PK interaction. It suggests that as an alternative to other acid-reducing agents, tegoprazan can be used concomitantly with CYP2C19 substrates in clinical settings.Trial RegistrationClinicaltrials.gov identifier: NCT04568772 (Registered on September 29, 2020). (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - March 10, 2023 Category: Drugs & Pharmacology Source Type: research
NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia
In this study, we examined the effect of NLRP3 inhibition on PE pathophysiology in the reduced uterine perfusion pressure (RUPP) model rat using MCC950 (20 mg/kg/day) or esomeprazole (3.5 mg/kg/day). We hypothesized that increased NLRP3 in response to placental ischemia impairs anti-inflammatory IL-33 signaling to induce T-helper17 cell (TH17) and cytolytic NK cell (cNK) activation, which is known to mediate oxidative stress and vascular dysfunction leading to maternal HTN and intrauterine growth restriction. RUPP rats had significantly higher placental NLRP3 expression, maternal blood pressure, fetal reabsorption rate, va...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 27, 2023 Category: Physiology Authors: Xi Wang Olivia K Travis Corbin A Shields G Ann Tardo Chelsea Giachelli Christopher W Nutter Hannah L Glenn Olive G Cooper Tatiana Davis Rashauna Thomas Jan M Williams Denise C Cornelius Source Type: research
NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia
In this study, we examined the effect of NLRP3 inhibition on PE pathophysiology in the reduced uterine perfusion pressure (RUPP) model rat using MCC950 (20 mg/kg/day) or esomeprazole (3.5 mg/kg/day). We hypothesized that increased NLRP3 in response to placental ischemia impairs anti-inflammatory IL-33 signaling to induce T-helper17 cell (TH17) and cytolytic NK cell (cNK) activation, which is known to mediate oxidative stress and vascular dysfunction leading to maternal HTN and intrauterine growth restriction. RUPP rats had significantly higher placental NLRP3 expression, maternal blood pressure, fetal reabsorption rate, va...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 27, 2023 Category: Physiology Authors: Xi Wang Olivia K Travis Corbin A Shields G Ann Tardo Chelsea Giachelli Christopher W Nutter Hannah L Glenn Olive G Cooper Tatiana Davis Rashauna Thomas Jan M Williams Denise C Cornelius Source Type: research
NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia
In this study, we examined the effect of NLRP3 inhibition on PE pathophysiology in the reduced uterine perfusion pressure (RUPP) model rat using MCC950 (20 mg/kg/day) or esomeprazole (3.5 mg/kg/day). We hypothesized that increased NLRP3 in response to placental ischemia impairs anti-inflammatory IL-33 signaling to induce T-helper17 cell (TH17) and cytolytic NK cell (cNK) activation, which is known to mediate oxidative stress and vascular dysfunction leading to maternal HTN and intrauterine growth restriction. RUPP rats had significantly higher placental NLRP3 expression, maternal blood pressure, fetal reabsorption rate, va...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 27, 2023 Category: Physiology Authors: Xi Wang Olivia K Travis Corbin A Shields G Ann Tardo Chelsea Giachelli Christopher W Nutter Hannah L Glenn Olive G Cooper Tatiana Davis Rashauna Thomas Jan M Williams Denise C Cornelius Source Type: research
NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia
In this study, we examined the effect of NLRP3 inhibition on PE pathophysiology in the reduced uterine perfusion pressure (RUPP) model rat using MCC950 (20 mg/kg/day) or esomeprazole (3.5 mg/kg/day). We hypothesized that increased NLRP3 in response to placental ischemia impairs anti-inflammatory IL-33 signaling to induce T-helper17 cell (TH17) and cytolytic NK cell (cNK) activation, which is known to mediate oxidative stress and vascular dysfunction leading to maternal HTN and intrauterine growth restriction. RUPP rats had significantly higher placental NLRP3 expression, maternal blood pressure, fetal reabsorption rate, va...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 27, 2023 Category: Physiology Authors: Xi Wang Olivia K Travis Corbin A Shields G Ann Tardo Chelsea Giachelli Christopher W Nutter Hannah L Glenn Olive G Cooper Tatiana Davis Rashauna Thomas Jan M Williams Denise C Cornelius Source Type: research
NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia
In this study, we examined the effect of NLRP3 inhibition on PE pathophysiology in the reduced uterine perfusion pressure (RUPP) model rat using MCC950 (20 mg/kg/day) or esomeprazole (3.5 mg/kg/day). We hypothesized that increased NLRP3 in response to placental ischemia impairs anti-inflammatory IL-33 signaling to induce T-helper17 cell (TH17) and cytolytic NK cell (cNK) activation, which is known to mediate oxidative stress and vascular dysfunction leading to maternal HTN and intrauterine growth restriction. RUPP rats had significantly higher placental NLRP3 expression, maternal blood pressure, fetal reabsorption rate, va...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 27, 2023 Category: Physiology Authors: Xi Wang Olivia K Travis Corbin A Shields G Ann Tardo Chelsea Giachelli Christopher W Nutter Hannah L Glenn Olive G Cooper Tatiana Davis Rashauna Thomas Jan M Williams Denise C Cornelius Source Type: research
NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia
In this study, we examined the effect of NLRP3 inhibition on PE pathophysiology in the reduced uterine perfusion pressure (RUPP) model rat using MCC950 (20 mg/kg/day) or esomeprazole (3.5 mg/kg/day). We hypothesized that increased NLRP3 in response to placental ischemia impairs anti-inflammatory IL-33 signaling to induce T-helper17 cell (TH17) and cytolytic NK cell (cNK) activation, which is known to mediate oxidative stress and vascular dysfunction leading to maternal HTN and intrauterine growth restriction. RUPP rats had significantly higher placental NLRP3 expression, maternal blood pressure, fetal reabsorption rate, va...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 27, 2023 Category: Physiology Authors: Xi Wang Olivia K Travis Corbin A Shields G Ann Tardo Chelsea Giachelli Christopher W Nutter Hannah L Glenn Olive G Cooper Tatiana Davis Rashauna Thomas Jan M Williams Denise C Cornelius Source Type: research
The Oral Bioavailability and Effect of Various Gastric Conditions on the Pharmacokinetics of Dersimelagon in Healthy Adult Volunteers
AbstractDersimelagon is a novel orally administered selective agonist for melanocortin receptor 1 being investigated for the treatment of erythropoietic protoporphyria, X-linked protoporphyria, and diffuse cutaneous systemic sclerosis. In this open-label, multicenter, randomized, two-cohort, sequential crossover study, the relative oral bioavailability of two tablet formulations of dersimelagon was evaluated, and the effect of various gastric conditions (from a high-fat meal, a proton-pump inhibitor, and an acidic carbonated beverage) on the pharmacokinetics of dersimelagon were assessed in healthy participants (N = 50)...
Source: Clinical Pharmacology in Drug Development - February 26, 2023 Category: Drugs & Pharmacology Authors: Kei Ogawa,
Ryosuke Ide,
Kirstine Belongie,
Minoru Tsuda,
Hiroki Kawanishi,
Renli Teng,
Akihito Ogasawara Tags: Original Article Source Type: research
Separation and Identification of Degradation Impurities of Esomeprazole Sodium
Biomed Chromatogr. 2023 Feb 2:e5593. doi: 10.1002/bmc.5593. Online ahead of print.ABSTRACTDrug impurities are important factors that affect drug safety and efficacy. The purpose of this study is to separate and confirm the structure of two degradation impurities of esomeprazole sodium, designated X and Y. The impurities X and Y were successfully isolated by preparative high-performance liquid chromatography via developing separation methods with the help of ACD/Labs AutoChrom software. There was a steady increase in X and Y impurities in forced esomeprazole sodium degradation. Impurity X was confirmed as 6-methoxy-1h-benzo...
Source: Biomedical Chromatography : BMC - February 3, 2023 Category: Biomedical Science Authors: Chuan Xiao Yingying Yuan Jianwang Li Yehua Han Jiamin Shi Wei Zeng Xiaolong Zu Huijie Jin Ru Jiang Shouhai Ni Source Type: research
Separation and Identification of Degradation Impurities of Esomeprazole Sodium
Biomed Chromatogr. 2023 Feb 2:e5593. doi: 10.1002/bmc.5593. Online ahead of print.ABSTRACTDrug impurities are important factors that affect drug safety and efficacy. The purpose of this study is to separate and confirm the structure of two degradation impurities of esomeprazole sodium, designated X and Y. The impurities X and Y were successfully isolated by preparative high-performance liquid chromatography via developing separation methods with the help of ACD/Labs AutoChrom software. There was a steady increase in X and Y impurities in forced esomeprazole sodium degradation. Impurity X was confirmed as 6-methoxy-1h-benzo...
Source: Biomedical Chromatography : BMC - February 3, 2023 Category: Biomedical Science Authors: Chuan Xiao Yingying Yuan Jianwang Li Yehua Han Jiamin Shi Wei Zeng Xiaolong Zu Huijie Jin Ru Jiang Shouhai Ni Source Type: research
Separation and Identification of Degradation Impurities of Esomeprazole Sodium
Biomed Chromatogr. 2023 Feb 2:e5593. doi: 10.1002/bmc.5593. Online ahead of print.ABSTRACTDrug impurities are important factors that affect drug safety and efficacy. The purpose of this study is to separate and confirm the structure of two degradation impurities of esomeprazole sodium, designated X and Y. The impurities X and Y were successfully isolated by preparative high-performance liquid chromatography via developing separation methods with the help of ACD/Labs AutoChrom software. There was a steady increase in X and Y impurities in forced esomeprazole sodium degradation. Impurity X was confirmed as 6-methoxy-1h-benzo...
Source: Biomedical Chromatography : BMC - February 3, 2023 Category: Biomedical Science Authors: Chuan Xiao Yingying Yuan Jianwang Li Yehua Han Jiamin Shi Wei Zeng Xiaolong Zu Huijie Jin Ru Jiang Shouhai Ni Source Type: research
Retraction note to: Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial
World J Gastroenterol. 2023 Jan 7;29(1):221-222. doi: 10.3748/wjg.v29.i1.221.ABSTRACT[This retracts the article on p. 2110 in vol. 25, PMID: 31114137.].PMID:36683720 | PMC:PMC9850955 | DOI:10.3748/wjg.v29.i1.221 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 23, 2023 Category: Gastroenterology Authors: Qing-Hua Sun Hong-Yan Wang Shi-Dong Sun Xin Zhang Han Zhang Source Type: research
