Clinical Effects of Biling Weitong Granules in Combination with Quadruple Therapy on Refractory Helicobacter pylori Infection
CONCLUSIONS: The combination of BLWTG and standard four-drug therapy had a high eradication rate and low recurrence rate in patients with refractory HP infection. Additionally, this combined therapy could regulate inflammatory reactions and reduce drug-related adverse reactions.PMID:37083648 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 21, 2023 Category: Complementary Medicine Authors: Ya-Lan Chen Zeng-Sheng Li Hui-Qing Zhang Da-Lei Chen Source Type: research
Clinical Effects of Biling Weitong Granules in Combination with Quadruple Therapy on Refractory Helicobacter pylori Infection
CONCLUSIONS: The combination of BLWTG and standard four-drug therapy had a high eradication rate and low recurrence rate in patients with refractory HP infection. Additionally, this combined therapy could regulate inflammatory reactions and reduce drug-related adverse reactions.PMID:37083648 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 21, 2023 Category: Complementary Medicine Authors: Ya-Lan Chen Zeng-Sheng Li Hui-Qing Zhang Da-Lei Chen Source Type: research
Clinical Effects of Biling Weitong Granules in Combination with Quadruple Therapy on Refractory Helicobacter pylori Infection
CONCLUSIONS: The combination of BLWTG and standard four-drug therapy had a high eradication rate and low recurrence rate in patients with refractory HP infection. Additionally, this combined therapy could regulate inflammatory reactions and reduce drug-related adverse reactions.PMID:37083648 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 21, 2023 Category: Complementary Medicine Authors: Ya-Lan Chen Zeng-Sheng Li Hui-Qing Zhang Da-Lei Chen Source Type: research
Clinical Effects of Biling Weitong Granules in Combination with Quadruple Therapy on Refractory Helicobacter pylori Infection
CONCLUSIONS: The combination of BLWTG and standard four-drug therapy had a high eradication rate and low recurrence rate in patients with refractory HP infection. Additionally, this combined therapy could regulate inflammatory reactions and reduce drug-related adverse reactions.PMID:37083648 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 21, 2023 Category: Complementary Medicine Authors: Ya-Lan Chen Zeng-Sheng Li Hui-Qing Zhang Da-Lei Chen Source Type: research
Clinical Effects of Biling Weitong Granules in Combination with Quadruple Therapy on Refractory Helicobacter pylori Infection
CONCLUSIONS: The combination of BLWTG and standard four-drug therapy had a high eradication rate and low recurrence rate in patients with refractory HP infection. Additionally, this combined therapy could regulate inflammatory reactions and reduce drug-related adverse reactions.PMID:37083648 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 21, 2023 Category: Complementary Medicine Authors: Ya-Lan Chen Zeng-Sheng Li Hui-Qing Zhang Da-Lei Chen Source Type: research
Clinical Effects of Biling Weitong Granules in Combination with Quadruple Therapy on Refractory Helicobacter pylori Infection
CONCLUSIONS: The combination of BLWTG and standard four-drug therapy had a high eradication rate and low recurrence rate in patients with refractory HP infection. Additionally, this combined therapy could regulate inflammatory reactions and reduce drug-related adverse reactions.PMID:37083648 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 21, 2023 Category: Complementary Medicine Authors: Ya-Lan Chen Zeng-Sheng Li Hui-Qing Zhang Da-Lei Chen Source Type: research
Minocycline vs. tetracycline in bismuth-containing quadruple therapy for Helicobacter pylori rescue treatment: a multicentre, randomized controlled trial
ConclusionsMinocycline can be an alternative for tetracycline in bismuth-containing quadruple therapy forH. pylori empirical rescue treatment, irrespective of metronidazole resistance. However, relatively high incidence of adverse events in both regimens should be emphasized. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 12, 2023 Category: Gastroenterology Source Type: research
Bismuth, esomeprazole, metronidazole, and minocycline or tetracycline as a first-line regimen for Helicobacter pylori eradication: A randomized controlled trial
CONCLUSION: The eradication efficacy of minocycline-containing BQT was noninferior to tetracycline-containing BQT as first-line regimen for H. pylori eradication with similar safety and compliance.TRIAL REGISTRATION: ClinicalTrials.gov, ChiCTR 1900023646.PMID:37010246 | DOI:10.1097/CM9.0000000000002629 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 3, 2023 Category: General Medicine Authors: Baojun Suo Xueli Tian Hua Zhang Haoping Lu Cailing Li Yuxin Zhang Xinlu Ren Xingyu Yao Liya Zhou Zhiqiang Song Source Type: research
Bismuth, esomeprazole, metronidazole, and minocycline or tetracycline as a first-line regimen for Helicobacter pylori eradication: A randomized controlled trial
CONCLUSION: The eradication efficacy of minocycline-containing BQT was noninferior to tetracycline-containing BQT as first-line regimen for H. pylori eradication with similar safety and compliance.TRIAL REGISTRATION: ClinicalTrials.gov, ChiCTR 1900023646.PMID:37010246 | DOI:10.1097/CM9.0000000000002629 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 3, 2023 Category: General Medicine Authors: Baojun Suo Xueli Tian Hua Zhang Haoping Lu Cailing Li Yuxin Zhang Xinlu Ren Xingyu Yao Liya Zhou Zhiqiang Song Source Type: research
Prediction of gastric pH ‐mediated drug exposure using physiologically‐based pharmacokinetic modeling: A case study of itraconazole
This study aimed to evaluate the utility of physiologically-based pharmacokinetic (PBPK) modeling in the prediction of gastric pH-mediated drug exposure by using itraconazole, a weak base, as a case. An itraconazole PBPK model was developed on the mechanistic basis of its absorption kinetics in a middle-out manner from a stepwise in vitro-in vivo extrapolation to in vivo refinement. Afterward, an independent prospective clinical study evaluating gastric pH and itraconazole pharmacokinetics (PKs) under normal gastric acidity and esomeprazole-induced gastric hypoacidity was conducted for model validation. Validation was perf...
Source: CPT: Pharmacometrics and Systems Pharmacology - March 27, 2023 Category: Drugs & Pharmacology Authors: Eunsol Yang,
Kyung ‐Sang Yu,
SeungHwan Lee Tags: ARTICLE Source Type: research
Effect of Food on the Pharmacokinetics and Pharmacodynamics of a Novel Dual Delayed ‐Release Formulation of Esomeprazole in Healthy Subjects
In conclusion, although the systemic exposure of esomeprazole decreased when DR esomeprazole was administered in the fed state compared to that in the fasted state, the degree of gast ric acid secretion inhibition was not clinically different, regardless of food intake. (Source: Clinical Pharmacology in Drug Development)
Source: Clinical Pharmacology in Drug Development - March 17, 2023 Category: Drugs & Pharmacology Authors: Sejung Hwang,
Sung Hee Hong,
Jina Jung,
Jae ‐Yong Chung,
In‐Jin Jang,
SeungHwan Lee Tags: Original Article Source Type: research
Evaluation of CYP2C19-Mediated Pharmacokinetic Drug Interaction of Tegoprazan, Compared with Vonoprazan or Esomeprazole
ConclusionTegoprazan, unlike vonoprazan and esomeprazole, exhibited negligible CYP2C19-mediated PK interaction. It suggests that as an alternative to other acid-reducing agents, tegoprazan can be used concomitantly with CYP2C19 substrates in clinical settings.Trial RegistrationClinicaltrials.gov identifier: NCT04568772 (Registered on September 29, 2020). (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - March 10, 2023 Category: Drugs & Pharmacology Source Type: research
