For patients with drug-resistant infections, infectious diseases experts may be lifesaving
(Infectious Diseases Society of America) Researchers analyzed records for approximately 4,200 patients with infections resistant to multiple antibiotics from 2006 to 2015 at one academic medical center. Thirty-day mortality rates were about 50 percent lower among patients with certain multidrug-resistant infections who had infectious diseases (ID) specialists involved in their care. Among patients with Enterobacteriaceae infections resistant to several antibiotics, an ID consultation was associated with a 59 percent reduction in 30-day mortality. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 23, 2018 Category: Infectious Diseases Source Type: news
NIH scientists describe potential antibody approach for treating multidrug-resistant Klebsiella pneumoniae
Promising concept may lead to an alternative to antibiotics. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - March 13, 2018 Category: American Health Source Type: news
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
(NIH/National Institute of Allergy and Infectious Diseases) Researchers are developing a promising alternative to antibiotic treatment for infections caused by Klebsiella pneumoniae bacteria resistant to carbapenem antibiotics. The approach uses antibodies to target the K. pneumoniae protective capsule polysaccharide, allowing immune system cells called neutrophils to attack and kill the bacteria. The early stage, in vitro research was conducted by scientists at NIAID's Rocky Mountain Laboratories and the New Jersey Medical School-Rutgers University. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 13, 2018 Category: Infectious Diseases Source Type: news
FDA Approves Ibalizumab for Multidrug-Resistant HIV-1 FDA Approves Ibalizumab for Multidrug-Resistant HIV-1
The FDA has approved ibalizumab-uiyk (Trogarzo, Theratechnologies Inc) for the treatment of adults with multidrug-resistant HIV-1.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 6, 2018 Category: Consumer Health News Tags: HIV/AIDS News Alert Source Type: news
FDA Approves Trogarzo (ibalizumab-uiyk) for Treatment-Experienced Patients with Multidrug Resistant HIV
March 6, 2018 -- Today, the U.S. Food and Drug Administration approved Trogarzo (ibalizumab-uiyk), a new type of antiretroviral medication for adult patients living with HIV who have tried multiple HIV medications in the past (heavily... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - March 6, 2018 Category: Drugs & Pharmacology Source Type: news
Tetraphase Pharmaceuticals Announces FDA Acceptance for Filing of its NDA Submission for Eravacycline for the Treatment of Complicated Intra-Abdominal Infections
WATERTOWN, Mass., Feb. 27, 2018 (GLOBE NEWSWIRE) -- Tetraphase Pharmaceuticals, Inc. (NASDAQ:TTPH), a biopharmaceutical company focused on developing and commercializing novel antibiotics to treat life-threatening multidrug-resistant (MDR)... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - February 27, 2018 Category: Drugs & Pharmacology Source Type: news
A path to multidrug resistance
(Source: ScienceNOW)
Source: ScienceNOW - February 22, 2018 Category: Science Authors: Vinson, V. Tags: Biochemistry, Medicine, Diseases twis Source Type: news
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
The multidrug transporter permeability (P)–glycoprotein is an adenosine triphosphate (ATP)–binding cassette exporter responsible for clinical resistance to chemotherapy. P-glycoprotein extrudes toxic molecules and drugs from cells through ATP-powered conformational changes. Despite decades of effort, only the structures of the inward-facing conformation of P-glycoprotein are available. Here we present the structure of human P-glycoprotein in the outward-facing conformation, determined by cryo–electron microscopy at 3.4-angstrom resolution. The two nucleotide-binding domains form a closed dimer occluding t...
Source: ScienceNOW - February 22, 2018 Category: Science Authors: Kim, Y., Chen, J. Tags: Biochemistry, Medicine, Diseases reports Source Type: news
In soil-dwelling bacteria, scientists find a new weapon to fight drug-resistant superbugs
It ’s a new class of antibiotic that promises to live up to its rough Latin translation: killer of bad guys.In a reportpublished this week in the journal Nature Microbiology, researchers describe a never-before-seen antibiotic agent that vanquished several strains of multidrug-resistant bacteria.... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - February 13, 2018 Category: Science Authors: Melissa Healy Source Type: news
Multidrug-resistant Malaria Outbreak Originated in Western Cambodia Multidrug-resistant Malaria Outbreak Originated in Western Cambodia
The current outbreak of multidrug-resistant malaria in Southeast Asia originated in western Cambodia soon after dihydroartemisinin-piperaquine became the first-line antimalarial drug there, according to a new genetic study.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 8, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news
Re-introducing an 'old' antibiotic may help fight multi-drug resistant bacteria
(Wiley) A new study indicates that the drug fosfomycin may be effective for treating multidrug-resistant bacterial infections. In most European countries, the oral formulation is only approved as a 3 gram single dose for the treatment of uncomplicated cystitis; however the Pharmacology Research& Perspectives study found that a dosing regimen of 6-12 grams per day divided in 3 doses is required for the treatment of systemic multi-drug-resistant bacterial infections. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 7, 2018 Category: International Medicine & Public Health Source Type: news
Malaria-Causing Parasite Mutating to Resist Multiple Drugs
FRIDAY, Feb. 2, 2018 -- An outbreak of multidrug-resistant malaria in southeast Asia likely stems from two mutations of the malaria-causing parasite that combined a decade ago, according to new research.
The parasite and mutations, carried by... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 2, 2018 Category: General Medicine Source Type: news
Reducing Antibiotic Use in Respiratory Syncytial Virus: A Quality Improvement Approach to Antimicrobial Stewardship
This research article examines how increased incidence of multidrug-resistant organisms is associated with increased morbidity, mortality, hospital length of stay, and cost. Estimates show that up to 50% of antimicrobial use is inappropriate. This initiative focuses on inappropriate use of antibiotics in respiratory syncytial virus (RSV) infections. This virus is the most common cause of bronchiolitis during childhood. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 25, 2018 Category: Consumer Health News Source Type: news
Emerging Multidrug-Resistant Candida Species Emerging Multidrug-Resistant Candida Species
Infections caused by multidrug-resistant Candida species are on the rise. How are these infections best treated?Current Opinion in Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 25, 2018 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
SHEA Updates Contact Precautions Recs for Drug-Resistant Bacteria SHEA Updates Contact Precautions Recs for Drug-Resistant Bacteria
The Society for Healthcare Epidemiology of America addresses when hospitals can safely stop protocols in the wake of multidrug-resistant infections and Clostridium difficile infections.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 12, 2018 Category: Consumer Health News Tags: Internal Medicine News Source Type: news
