Increasing usage of chlorhexidine in health care settings: blessing or curse? A narrative review of the risk of chlorhexidine resistance and the implications for infection prevention and control
This study reviewed the published data regarding the evidence of reduced CHG susceptibility, the cross-resistance with antibiotics, and the implications for infection control for S. aureus, coagulase-negative staphylococci, E. coli, K. pneumoniae, and P. aeruginosa. Despite incongruity in definitions of " resistance, " 12 increased CHG minimal inhibitory values of these pathogens have been described, and different mutations encoding for CHG efflux pumps have been identified. Clinical relevance of species with reduced susceptibility to CHG is debatable and cross-resistance with antibiotics remains controversial. However, so...
Source: Current Awareness Service for Health (CASH) - May 17, 2022 Category: Consumer Health News Source Type: news
Support for Gilead Drug's Benefit Against Multidrug-Resistant HIV Support for Gilead Drug's Benefit Against Multidrug-Resistant HIV
Lenacapavir produces higher levels of viral suppression after 26 weeks among patients with multidrug-resistant disease when given in addition to other antiretrovirals, according to results from the CAPELLA trial.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - May 12, 2022 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news
Lenacapavir Reduces Viral Load in Multidrug-Resistant HIV-1 Infection
THURSDAY, May 12, 2022 -- Patients with multidrug-resistant HIV-1 infection receiving the capsid inhibitor lenacapavir have a greater reduction in viral load than those receiving placebo, according to a study published in the May 12 issue of the New... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 12, 2022 Category: Pharmaceuticals Source Type: news
Africa: WHO Issues Rapid Communication On Updated Guidance for the Treatment of Drug-Resistant Tuberculosis
[WHO] A rapid communication released by the World Health Organization (WHO) Global Tuberculosis Programme has announced upcoming updates to the guidance on the treatment of drug-resistant tuberculosis (DR-TB). These updates include shorter novel 6-month all-oral regimens for the treatment of multidrug- and rifampicin-resistant TB (MDR/RR-TB), with or without additional resistance to fluoroquinolones (pre-XDR-TB) as well as an alternative 9-month all-oral regimen for the treatment of MDR/RR-TB. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - May 9, 2022 Category: Infectious Diseases Source Type: news
Africa: Drug-Resistant Tuberculosis Trial Results in Updated Treatment Guidelines
[MSF] Geneva -- The World Health Organization (WHO) has announced it will update global guidance on treatment of multidrug-resistant tuberculosis (MDR-TB), following the results shared from the TB PRACTECAL trial. The clinical trial from M édecins Sans Frontières (MSF) has found a new, safer and more effective six-month oral treatment regimen for MDR-TB. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - May 6, 2022 Category: Infectious Diseases Source Type: news
Global rollout of rapid molecular tests for tuberculosis over the last 12 years: Cochrane Review summarizes research on recipient and provider views
A potential game-changer in the tuberculosis epidemic was how the tuberculosis community viewed rapid molecular tests for tuberculosis and tuberculosis drug resistance. This was 12 years ago, with the launch of Xpert MTB/RIF, which gives results in less than two hours, simultaneously diagnosing tuberculosis and testing if the bacteria have rifampicin resistance, a type of drug-resistant tuberculosis. Multidrug-resistant tuberculosis is caused by resistance to at least both rifampicin and isoniazid, the two most effective first-line drugs used to treat tuberculosis. Yet, diagnostic tests only have an impact on health if t...
Source: Cochrane News and Events - May 2, 2022 Category: Information Technology Authors: Muriah Umoquit Source Type: news
Johnson & Johnson Launches Next Satellite Center for Global Health Discovery at Holistic Drug Discovery and Development Centre, University of Cape Town, Focused on Antimicrobial Resistance (AMR)
Cape Town, South Africa, April 25, 2022 – Johnson & Johnson (the Company) today announced the launch of the J&J Satellite Center for Global Health Discovery (Satellite Center) at the Holistic Drug Discovery and Development (H3D) Centre, University of Cape Town, in Cape Town, South Africa. This marks the latest expansion of the J&J Centers for Global Health Discovery (J&J Centers), a global network of research collaborations between the Company and leading research institutions to accelerate translational and discovery research to address some of the world’s most pressing global health challenges. The Sa...
Source: Johnson and Johnson - April 25, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Cleaning and disinfecting surfaces in hospitals and long-term care facilities for reducing hospital- and facility-acquired bacterial and viral infections: a systematic review
Conclusion: Ten c-RCTs focused on reducing multiple MDROs and/or HAIs and four had significant reductions. Three c-RCTs reported only patient MRSA colonization rates (o ne significant reductions), and one focused on C. difficile (no significant differences). Standardized primary and secondary outcomes are required for future c-RCTs including detailed biofilm cleaning/disinfection interventions. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 21, 2022 Category: Consumer Health News Source Type: news
An easy-to-use antimicrobial hydrogel effectively kills bacteria, fungi, and influenza virus
Various drug resistant pathogens such as bacteria, fungi and viruses enter a host through different routes, which can lead to health-related problems and even fatalities. Propagation of these infectious microbes majorly occurs through the mucosal openings or upon topical contact. To curb their transmission or to cure infections associated with these pathogens, herein we describe the development of an antimicrobial hydrogel, based on a water soluble quaternary lipophilic polyethyleneimine derivative (QPEINH-C6). The cationic polymer QPEINH-C6 exhibited antibacterial activity against drug-resistant Gram-positive bacteria (MI...
Source: Current Awareness Service for Health (CASH) - April 21, 2022 Category: Consumer Health News Source Type: news
Johnson & Johnson Announces Series of Youth Initiatives Aimed at Helping to Empower a Generation to End Tuberculosis
NEW BRUNSWICK, N.J., March 24, 2022 – Today on World Tuberculosis (TB) Day, Johnson & Johnson (the Company) announced a series of initiatives in high TB burden countries aimed at helping to empower a generation of youth to end TB. The initiatives focus on supporting global efforts to help find the missing millions of people living with undiagnosed TB, and are part of Johnson & Johnson’s 10-year initiative to help drive progress toward the United Nations (UN) Sustainable Development Goal of ending this deadly, but preventable and treatable, disease by 2030.Johnson & Johnson, together with the Central TB Divi...
Source: Johnson and Johnson - March 24, 2022 Category: Pharmaceuticals Source Type: news
Increasing usage of chlorhexidine in health care settings: blessing or curse? A narrative review of the risk of chlorhexidine resistance and the implications for infection prevention and control
This study reviewed the published data regarding the evidence of reduced CHG susceptibility, the cross-resistance with antibiotics, and the implications for infection control for S. aureus, coagulase-negative staphylococci, E. coli, K. pneumoniae, and P. aeruginosa. Despite incongruity in definitions of " resistance, " increased CHG minimal inhibitory values of these pathogens have been described, and different mutations encoding for CHG efflux pumps have been identified. Clinical relevance of species with reduced susceptibility to CHG is debatable and cross-resistance with antibiotics remains controversial. However, some ...
Source: Current Awareness Service for Health (CASH) - March 21, 2022 Category: Consumer Health News Source Type: news
Fosfomycin Not Noninferior to Comparators for Bacteremic UTI
FRIDAY, Jan. 14, 2022 -- For patients with bacteremic urinary tract infections (bUTIs) due to multidrug-resistant (MDR) Escherichia coli, fosfomycin is not noninferior to comparators, with an increased rate of adverse event-related discontinuations,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 14, 2022 Category: Pharmaceuticals Source Type: news
Environmental Shedding of MRSA Is Far Greater than from Multidrug-Resistant Gram-Negative Bacilli
An observational cohort study revealed shedding of methicillin-resistant Staphylococcus aureus by colonized patients outside hospital rooms or during outpatient clinic visits occurred more often than in those colonized by multidrug-resistant gram-negative bacilli. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news
Does high adherence to contact precautions lead to low in-hospital transmission of multidrug-resistant microorganisms in the endemic setting? "
Conclusion: High adherence coupled with continuous monitoring of CP correlated to a very low in-hospital transmission rate. These results indicate that CP is highly effective if routine monitoring of adherence is implemented. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news
How Genomic Sequencing Data Tracked a Salmonella Outbreak How Genomic Sequencing Data Tracked a Salmonella Outbreak
Data on bacterial DNA helped reveal how a once-rare salmonella strain spread through the chicken industry. Salmonella infantis is multidrug-resistant and is still making people sick.ProPublica (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - November 5, 2021 Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news
