International Spread of Multidrug-Resistant Rhodococcus equi International Spread of Multidrug-Resistant Rhodococcus equi
The pathogen Rhodococcus equi has been spreading among horse farms in the United States, but now may have also spread to other countries.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 5, 2022 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
Study Affirms Shorter Regimens for Drug-Resistant Tuberculosis Study Affirms Shorter Regimens for Drug-Resistant Tuberculosis
Two short-course bedaquiline-containing regimens are promising treatment options for multidrug-resistant tuberculosis.Medscape Medical News (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - November 17, 2022 Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news
Johnson & Johnson Rises to #2 in Ranking of Companies ’ Efforts to Expand Access to Medicines Worldwide
Everyone should have the opportunity to lead a healthy life. This requires that we advance equitable access to healthcare and address some of the world’s most devastating and neglected diseases.We are proud that Johnson & Johnson’s actions to expand access to our medicines and focus on addressing diseases that disproportionately impact people in lower- and middle-income countries has made us the 2nd-ranked company globally in the 2022 Access to Medicine Index.Our industry-leading performance marks an improvement, up from 3rd in 2021, and is the sixth consecutive time we are featured as a top three performer by the ...
Source: Johnson and Johnson - November 15, 2022 Category: Pharmaceuticals Source Type: news
Antibiotic treatment in patients with sepsis: a narrative review
Sepsis is a medical emergency and life-threatening condition due to a dysregulated host response to infection, with unacceptably high morbidity and mortality. Similar to acute myocardial infarction or cerebral vascular accident, sepsis is a severe and continuous time-dependent condition. Thus, in the case of sepsis, early and adequate administration of antimicrobials must be a priority, ideally within the first hour of diagnosis, simultaneously with organ support.As a consequence of the emergence of multidrug-resistant pathogens, the choice of antimicrobials should be performed according to the local pathogen patterns of r...
Source: Current Awareness Service for Health (CASH) - September 9, 2022 Category: Consumer Health News Source Type: news
PAN-TB Collaboration to Advance Investigational Tuberculosis Drug Regimens to Phase 2 Clinical Trials
August 17, 2022 – The Project to Accelerate New Treatments for Tuberculosis (PAN-TB) collaboration announced today the execution of a joint development agreement (JDA) supporting the progression of two investigational tuberculosis (TB) combination treatment regimens into phase 2 clinical development. The collaboration will evaluate whether the novel regimens, which combine registered products and new chemical entities (NCEs), can effectively treat all forms of active pulmonary TB using substantially shorter treatment durations than existing drug regimens, with the goal of identifying a regimen suitable for phase 3 develo...
Source: Johnson and Johnson - August 17, 2022 Category: Pharmaceuticals Source Type: news
Antibiotic treatment in patients with sepsis: a narrative review
Sepsis is a medical emergency and life-threatening condition due to a dysregulated host response to infection, with unacceptably high morbidity and mortality. Similar to acute myocardial infarction or cerebral vascular accident, sepsis is a severe and continuous time-dependent condition. Thus, in the case of sepsis, early and adequate administration of antimicrobials must be a priority, ideally within the first hour of diagnosis, simultaneously with organ support.As a consequence of the emergence of multidrug-resistant pathogens, the choice of antimicrobials should be performed according to the local pathogen patterns of r...
Source: Current Awareness Service for Health (CASH) - August 15, 2022 Category: Consumer Health News Source Type: news
Algorithm Can Help Guide Antibiotic Use in Acute Pancreatitis Algorithm Can Help Guide Antibiotic Use in Acute Pancreatitis
Physicians could incorporate a procalcitonin-based algorithm into their daily practice to help curb the rise of multidrug-resistant organisms.MDedge News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 1, 2022 Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Structure-oriented design strategy to construct NIR AIEgens to selectively combat gram (+) multidrug-resistant bacteria in vivo.
Multidrug-resistant (MDR) gram-positive bacteria are an inevitable source of infection for hospitalized patients and one of the reasons for the increased proportion of severe diseases. Therefore, constructing smart agents for specific and effective combating infections in vivo caused by MDR gram-positive strains is very urgent. Herein, we reported a structure-oriented design strategy (SODS) to reasonably construct an organic photo-antimicrobial near-infrared (NIR) AIEgen BDPTV equipped with a phenylboronic acid moiety, which could be bound to the thick peptidoglycan layer of MDR gram-positive bacteria, resulting in a tight...
Source: Current Awareness Service for Health (CASH) - July 20, 2022 Category: Consumer Health News Source Type: news
Global trends in gut microbiota and clostridioides difficile infection research: A visualized study.
Conclusions: Gut microbiota and CDI is likely to remain a prominent area of research in the foreseeable future. Current research hotspots ( " fecal microbiota transplantation, " " colonization resistance, " and " multidrug-resistant bacteria " ) should receive even more attention in future studies. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 20, 2022 Category: Consumer Health News Source Type: news
Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations
Conclusion: Using a diagnostic technique to detect sepsis early on is more cost-effective than standard care. Setting a direct relationship between the implementation of a testing strategy and the reduction of AMR cases, we made several assumptions about the efficacy of antibiotics and the length-of-stay of patients. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 11, 2022 Category: Consumer Health News Source Type: news
Johnson & Johnson Opens First Satellite Center for Global Health Discovery in Asia Pacific at Duke-NUS to Advance Dengue Research
SINGAPORE, June 21, 2022 – Johnson & Johnson (the Company) today announced the launch of the new J&J Satellite Center for Global Health Discovery (Satellite Center) at Singapore’s Duke-NUS Medical School, jointly established by Duke University and the National University of Singapore (NUS) as a graduate-entry medical school and research powerhouse. As the first of the J&J Centers for Global Health Discovery (J&J Centers) in the Asia-Pacific region, the Satellite Center at Duke-NUS aims to help drive new solutions to address flaviviruses, which disproportionately impact communities across the region, by ...
Source: Johnson and Johnson - June 21, 2022 Category: Pharmaceuticals Source Type: news
Analyzing the Cost of Hospital Contact Isolation Practices: Implications for Nursing Administrator Practice, Research, and Policy
This study aimed to determine the weekly costs of contact precaution (CP) use with medically stable patients infected/colonized with methicillin-resistant Staphylococcus aureus (MRSA) and to estimate the annual financial and environmental costs of CP. Background: The increasing use of disposables for infection control contributes to increasing hospital costs and amounts of solid waste at rates that are becoming unsustainable. Methods: A cost analysis was conducted using data from time/motion observations and previous waste audit study, along with hospital finance department values and US Department of Labor salary rates. R...
Source: Current Awareness Service for Health (CASH) - June 17, 2022 Category: Consumer Health News Source Type: news
Laboratory-identified vancomycin-resistant enterococci bacteremia incidence: A standardized infection ratio prediction model.
We analyzed 2017 healthcare facility-onset (HO) vancomycin-resistant Enterococcus (VRE) bacteremia data to identify hospital-level factors that were significant predictors of HO-VRE using the Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN) multidrug-resistant organism and Clostridioides difficile reporting module. A risk-adjusted model that can be used to calculate the number of predicted HO-VRE bacteremia events in a facility was developed, thus enabling the calculation of VRE standardized infection ratios (SIRs).
Methods: Acute-care hospitals reporting at least 1 month of 2017 ...
Source: Current Awareness Service for Health (CASH) - June 16, 2022 Category: Consumer Health News Source Type: news
Multidrug-Resistant Bloodstream Infections in Internal Medicine Multidrug-Resistant Bloodstream Infections in Internal Medicine
This study analyzed trends of multidrug-resistant organism bacteremia and antimicrobial resistance rates in the complex setting of an Internal Medicine ward.Southern Medical Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 6, 2022 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
Increasing usage of chlorhexidine in health care settings: blessing or curse? A narrative review of the risk of chlorhexidine resistance and the implications for infection prevention and control
This study reviewed the published data regarding the evidence of reduced CHG susceptibility, the cross-resistance with antibiotics, and the implications for infection control for S. aureus, coagulase-negative staphylococci, E. coli, K. pneumoniae, and P. aeruginosa. Despite incongruity in definitions of " resistance, " 12 increased CHG minimal inhibitory values of these pathogens have been described, and different mutations encoding for CHG efflux pumps have been identified. Clinical relevance of species with reduced susceptibility to CHG is debatable and cross-resistance with antibiotics remains controversial. However, so...
Source: Current Awareness Service for Health (CASH) - May 17, 2022 Category: Consumer Health News Source Type: news
