Resistant Infections in Emergency Department Patients with Suspected Sepsis. The American journal of the medical sciences 360(6): 650-655.
Background: Inappropriate antibiotic therapy in sepsis is associated with poor outcomes, clinicians often provide routine coverage for multidrug resistant (MDR) bacteria. However, these regimens may contribute to problems related to antibiotic overuse. To understand the incidence and related factors of multidrug resistant bacterial infections in ED patients with sepsis, we examined how often patients with sepsis in our emergency department had MDR infections. We also explored risk factors for, and outcomes from, MDR bacterial infections.; Methods: We reviewed records of patients presenting to our emergency department (ED) ...
Source: Current Awareness Service for Health (CASH) - January 8, 2021 Category: Consumer Health News Source Type: news
Quick and sensitive identification of multidrug-resistant germs
(Swiss Nanoscience Institute, University of Basel) Researchers from the University of Basel have developed a sensitive testing system that allows the rapid and reliable detection of resistance in bacteria. The system is based on tiny, functionalized cantilevers that bend due to binding of sample material. In the analyses, the system was able to detect resistance in a sample quantity equivalent to 1-10 bacteria. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - December 7, 2020 Category: Biology Source Type: news
South Africa: Government Should Be Buying Its Pharmaceuticals Locally - - Especially Now
[Daily Maverick] Someone very special to me is ill with multidrug-resistant TB. As TB is the leading cause of death in South Africa, and a particularly unpleasant disease, this is a scary diagnosis. But she is young, receiving the best of care and will survive. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - November 25, 2020 Category: Infectious Diseases Source Type: news
The Difference Between Multidrug-Resistant TB MDR-TB and Extensively Drug-Resistant TB XDR-TB
Title: The Difference Between Multidrug-Resistant TB MDR-TB and Extensively Drug-Resistant TB XDR-TBCategory: Diseases and ConditionsCreated: 11/18/2020 12:00:00 AMLast Editorial Review: 11/18/2020 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - November 18, 2020 Category: Respiratory Medicine Source Type: news
Calcium bursts kill drug-resistant tumor cells
(American Chemical Society) Multidrug resistance (MDR) -- a process in which tumors become resistant to multiple medicines -- is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS'Nano Letters have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2020 Category: International Medicine & Public Health Source Type: news
Researchers awarded over $11 million to study multi-drug resistant infection factors
(University of Texas Health Science Center at Houston) A study aimed at better understanding why some critically ill patients develop multidrug-resistant infections is underway by researchers at The University of Texas Health Science Center at Houston (UTHealth). The multi-institution study will enroll patients at Memorial Hermann Hospital-Texas Medical Center and The University of Texas MD Anderson Cancer Center. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 14, 2020 Category: Infectious Diseases Source Type: news
Sepsis in surgical inpatients: under-recognised but with significant consequences
Conclusion(s): Sepsis was under-documented, and barriers exist with use of the national sepsis screening form. Frailty, which is a sepsis risk factor, should be assessed pre-operatively to maximise prevention. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news
Multidrug Resistance Common in Hospitalized Adults With HIV in Malawi Multidrug Resistance Common in Hospitalized Adults With HIV in Malawi
HIV-1 multidrug resistance is common and is associated with increased mortality among adults hospitalized with HIV infection in Malawi, according to a new study.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - September 18, 2020 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news
Identifying Facilities at Risk of Receiving MDRO Patients Identifying Facilities at Risk of Receiving MDRO Patients
A novel new tool may help identify which healthcare facilities are at risk of receiving patients infected with multidrug-resistant organisms.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 9, 2020 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
Notes from the Field: Multidrug-Resistant Tuberculosis Among Workers at Two Food Processing Facilities - Ohio, 2018-2019
This report describes an investigation of three cases of multidrug-resistant tuberculosis that occurred at two food processing facilities in Ohio. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - August 13, 2020 Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report Multidrug-Resistant TB (MDR TB) Tuberculosis (TB) Source Type: news
Test accurately IDs people whose gonorrhea can be cured with simple oral antibiotic
A test designed by UCLA researchers can pinpoint which people with gonorrhea will respond successfully to the inexpensive oral antibiotic ciprofloxacin, which had previously been sidelined over concerns the bacterium that causes the infection was becoming resistant to it.In research published in the peer-reviewed journal Clinical Infectious Diseases,a UCLA-led team found thatof106 subjectsthe test identified as having a strain ofgonorrhea called wild-type gyrA serine, all were cured with a single dose of oral ciprofloxacin. Though the test has been available for three years, this is the first time it has been systematicall...
Source: UCLA Newsroom: Health Sciences - August 12, 2020 Category: Universities & Medical Training Source Type: news
New generation of drugs show early efficacy against drug-resistant TB
(Harvard Medical School) New drug regimen for multidrug-resistant tuberculosis shows early effectiveness in 85 percent of patients in a cohort including many with serious comorbidities. The results suggest a global need for expanded access to two recently developed medicines, bedaquiline and delamanid. Study cohort included many people who would have been excluded from trials because of comorbidities, severity of disease or extent of drug resistance. Findings highlight the importance of innovative regimens to improve outcomes for patients with multidrug-resistant tuberculosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 12, 2020 Category: International Medicine & Public Health Source Type: news
Africa: TB Alliance Announces European Commission Authorisation of New Treatment for Highly Drug-Resistant Tuberculosis
[TB Alliance] PRETORIA (3 August 2020)--Pretomanid, a novel compound developed by the non-profit organization TB Alliance, has been granted a conditional marketing authorisation by the European Commission (EC) for treating highly drug-resistant forms of pulmonary tuberculosis (TB).[i] The new drug was authorised as part of a three-drug, six month, all-oral regimen for the treatment of adults with extensively drug-resistant TB (XDR-TB) or multidrug-resistant TB (MDR-TB) who are treatment-intolerant or non-responsive (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - August 4, 2020 Category: Infectious Diseases Source Type: news
Johnson & Johnson Reports 2020 Second-Quarter Results
New Brunswick, N.J. (July 16, 2020) – Johnson & Johnson (NYSE: JNJ) today announced results for second-quarter 2020. “Our second quarter results reflect the impact of COVID-19 and the enduring strength of our Pharmaceutical business, where we saw continued growth even in this environment,” said Alex Gorsky, Chairman and Chief Executive Officer. “Thanks to the tireless work of our colleagues around the world and our broad range of capabilities, we continue to successfully navigate the external landscape, and we remain focused on advancing the development of a vaccine to help address this pandemic and save lives....
Source: Johnson and Johnson - July 16, 2020 Category: Pharmaceuticals Source Type: news
Our Pets May Harbor Much More Than Coronavirus
While concern over SARS-CoV-2 in dogs and cats has captured attention, scientists have also been investigating whether pets can transmit multidrug-resistant bacteria to us. (Source: The Scientist)
Source: The Scientist - July 13, 2020 Category: Science Tags: Notebook Magazine Issue Source Type: news
