FDA OKs First-in-Class HIV Therapy for Patients With Few Options FDA OKs First-in-Class HIV Therapy for Patients With Few Options
Fostemsavir (Rukobia) is indicated for heavily treatment-experienced patients living with multidrug-resistant HIV infection.FDA Approvals (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - July 7, 2020 Category: Drugs & Pharmacology Tags: HIV/AIDS News Alert Source Type: news
Stop TB Partnership and Johnson & Johnson, with support from USAID and The Global Fund, Announce Price Reduction for SIRTURO ® (bedaquiline) for Treatment of Drug-Resistant Tuberculosis in Low- and Middle-Income Countries
GENEVA, SWITZERLAND, 6 JULY 2020 – The Stop TB Partnership and Johnson & Johnson – with support from the Global Fund to Fight AIDS, TB and Malaria, and the U.S. Agency for International Development (USAID) – today announced joint efforts to help enable low- and middle-income countries to rapidly scale up use of SIRTURO® (bedaquiline) 100mg tablets in support of new, recently-released World Health Organization (WHO) treatment guidelines. Effective immediately, Johnson & Johnson will make bedaquiline available to Stop TB Partnership’s Global Drug Facility (GDF) at a price of USD$340 per six-month treatment c...
Source: Johnson and Johnson - July 6, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news
A novel mechanism of mitochondrial dysfunctions-triggered the calcium signalling-dependent fungal multidrug resistance
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2020 Category: Respiratory Medicine Authors: MeganB Source Type: news
Clinical outcomes of empirical high-dose meropenem in critically ill patients with sepsis and septic shock: A randomized controlled trial
Conclusion(s): Empirical therapy with the high-dose meropenem presented comparable clinical outcomes to the standard-dose meropenem in sepsis and septic shock patients. Besides, subgroup analysis manifested superior microbiological cure rate in sepsis or septic shock patients admitted from ED. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news
FDA Approves New Pediatric Formulation of Sirturo (bedaquiline) as Part of Combination Therapy to Treat Children with Pulmonary Multidrug-Resistant Tuberculosis
NEW BRUNSWICK, NJ, May 27, 2020— The Janssen Pharmaceutical Companies of Johnson& Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of Sirturo (bedaquiline).... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - May 27, 2020 Category: Drugs & Pharmacology Source Type: news
U.S. FDA Approves New Pediatric Formulation of SIRTURO ® (bedaquiline) as Part of Combination Therapy to Treat Children with Pulmonary Multidrug-Resistant Tuberculosis
NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO®
(bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received accelerated appro...
Source: Johnson and Johnson - May 27, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news
FMT Helps Without Clearing Multidrug-Resistant Organisms FMT Helps Without Clearing Multidrug-Resistant Organisms
For seriously ill patients with multidrug-resistant organisms in their gastrointestinal tract, fecal microbiota transplant (FMT) might result in fewer and less severe infections, investigators report.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 20, 2020 Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Antibiotic exposure can 'prime' single-resistant bacteria to become multidrug-resistant
(University of Washington) Researchers at the University of Washington and the University of Idaho report that, for a bacterial pathogen already resistant to an antibiotic, prolonged exposure to that antibiotic not only boosted its ability to retain its resistance gene, but also made the pathogen more readily pick up and maintain resistance to a second antibiotic and become a dangerous, multidrug-resistant strain. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 27, 2020 Category: International Medicine & Public Health Source Type: news
Study suggests pets are not a major source of transmission of drug-resistant microbes to their owners
(European Society of Clinical Microbiology and Infectious Diseases) New research due to be presented at this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) has identified genetically identical multidrug-resistant bacteria in humans and their pets, suggesting human-animal transfer is possible in this context. However only a small number of cases were found, suggesting this is not a major source of antibiotic-resistant infections in humans. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 19, 2020 Category: International Medicine & Public Health Source Type: news
Study reveals raw-type dog foods as a major source of multidrug-resistant bacteria that could potentially colonize humans
(European Society of Clinical Microbiology and Infectious Diseases) New research due to be presented at this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) reveals that raw-type dog foods contain high levels of multidrug-resistant bacteria, including those resistant to last-line antibiotics. The potential transfer of such bacteria between dogs and humans is an international public health risk. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 19, 2020 Category: International Medicine & Public Health Source Type: news
Cancer drug resistance study raises immune red flags
(Scripps Research Institute) Once a cancer patient's tumors develop resistance to chemotherapy, the prognosis can be poor. However, inhibiting a key gene involved in multidrug resistance, MDR1, has not improved outcomes. A new study offers a reason, revealing unintended downstream effects on immune system cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 17, 2020 Category: Biology Source Type: news
Suppressing Stomach Acid May Up Intestinal Growth of MDROs
THURSDAY, April 9, 2020 -- Stomach acid suppression medications increase the odds of intestinal colonization with multidrug-resistant microorganisms (MDROs), according to a review and meta-analysis recently published in JAMA Internal Medicine.
Roel... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 9, 2020 Category: Pharmaceuticals Source Type: news
Some Multidrug-Resistant Bacterial Infections Down in U.S.
WEDNESDAY, April 8, 2020 -- From 2012 to 2017, there were decreases in the incidence of some multidrug-resistant (MDR) bacterial infections in hospitalized patients in the United States, according to a study published in the April 2 issue of the New... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 8, 2020 Category: Pharmaceuticals Source Type: news
EMA Panel Backs Pretomanid for Drug-Resistant TB EMA Panel Backs Pretomanid for Drug-Resistant TB
Pretomanid FGK, in combination with bedaquiline and linezolid, is for adults with extensively drug-resistant, treatment-intolerant, or nonresponsive multidrug-resistant tuberculosis.International Approvals (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - March 31, 2020 Category: Drugs & Pharmacology Tags: Infectious Diseases News Source Type: news
Fostemsavir Active in Multidrug-Resistant HIV-1 Infection
THURSDAY, March 26, 2020 -- Amongpatients with multidrug-resistant HIV-1 infection who have limited therapy options, reductions in HIV-1 RNA level were significantly greater in those who received fostemsavir compared with placebo during the first... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 26, 2020 Category: Pharmaceuticals Source Type: news
