Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling
Modelling study estimates a global prevalence of latent MDR tuberculosis infection carriage of 0.3%. It predicts that the proportion of latent tuberculosis caused by MDR strains will increase, which will pose serious challenges for management of latent tuberculosis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 12, 2019 Category: Consumer Health News Source Type: news
New TB blood test may ID patients most at risk
Blood test stems from work with livestock Related items fromOnMedica TB could be cured by four months ’ treatment in many patients Tuberculosis cases continue to fall Multidrug-resistant TB spreads less easily than ‘normal’ TB Tuberculosis rates in England fall BMJ report questions swine flu jab transparency (Source: OnMedica Latest News)
Source: OnMedica Latest News - July 9, 2019 Category: UK Health Source Type: news
North Korea Has Two Weapons Of Mass Destruction: Nukes And Tuberculosis
There is a joke in China that the North Korean ’s have two weapons of mass destruction, nukes and tuberculosis. And not just TB, but multidrug resistant TB, which knows no boundaries or borders, and is spread person to person through the air. Trump went to North Korea to discuss denuclearization. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - July 1, 2019 Category: Pharmaceuticals Authors: Nicole Fisher, Contributor Source Type: news
NIH launches large TB prevention trial for people exposed to multidrug-resistant TB
Study will compare delamanid to isoniazid for preventing TB disease in at-risk contacts. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - June 25, 2019 Category: American Health Source Type: news
Combination of drugs may combat deadly drug-resistant fungus
(Beth Israel Deaconess Medical Center) Microbiologists at Beth Israel Deaconess Medical Center have shown that a combination of anti-fungal and anti-bacterial medications may be an effective weapon against the recently discovered multidrug resistant, Candida auris (C. auris). (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 21, 2019 Category: Biology Source Type: news
Risk Factors for 30-Day Mortality in Neonatal Gram-Negative Bacilli Sepsis
Multidrug-resistant gram-negative bacilli (MDR-GNB) have emerged globally as a serious threat and with a high case fatality rate (CFR). Neonates suspected of sepsis with septic shock need broad-spectrum empirical antimicrobial therapy until the second successive negative culture, especially in high MDR areas. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 19, 2019 Category: Consumer Health News Source Type: news
Medline Announces First Infection Control Product EPA-registered to Kill Emerging Pathogen
Micro-Kill Bleach Germicidal Bleach Wipes shown to kill Candida auris
First EPA approved product on market* available to hospitals and clinics fighting multidrug resistant fungus
NORTHFIELD, Ill., June 14, 2019 -- (Healthcare Sales & Marketing Networ... Devices, FDA, Product Launch, Distribution Medline, Micro-Kill Bleach (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 14, 2019 Category: Pharmaceuticals Source Type: news
Human contact plays big role in spread of some hospital infections, but not others
(Institut Pasteur) An observational study conducted in a French hospital showed that human contact was responsible for 90 percent of the spread of one species of antibiotic-resistant bacteria to new patients, but less than 60 percent of the spread of a different species. These findings suggest hand hygiene is a key, but more methods are needed to fight multidrug-resistant infection. Audrey Duval of the Versailles Saint Quentin University and the Institut Pasteur in Paris, France, and colleagues present these results in PLOS Computational Biology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 14, 2019 Category: International Medicine & Public Health Source Type: news
Outcomes of Bedaquiline Treatment in Multidrug-Resistant TB Outcomes of Bedaquiline Treatment in Multidrug-Resistant TB
What do we know about the treatment success rate of bedaquiline in multidrug-resistant tuberculosis?Emerging Infectious Diseases (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - June 7, 2019 Category: Infectious Diseases Tags: Infectious Diseases Journal Article Source Type: news
Ticagrelor: A New Antibiotic?
The antiplatelet agent ticagrelor (Brilinta/Brilique, AstraZeneca) demonstrated bactericidal activity against antibiotic-resistant gram-positive bacteria that pose a threat to human health, including methicillin-resistant Staphylococcus aureus (MRSA), and may represent a new class of antibiotic active against multidrug-resistant staphylococci or enterococci, new research suggests. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 7, 2019 Category: Consumer Health News Source Type: news
Proteasome inhibitors show promise for drug-resistant malaria
(PLOS) Proteasome inhibitors have significant promise as components of novel combination therapies to treat multidrug-resistant malaria, according to a study published June 6 in the open-access journal PLOS Pathogens by David Fidock, Caroline Ng, and Barbara Stokes of Columbia University Irving Medical Center, Matthew Bogyo of Stanford University School of Medicine, and colleagues. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 6, 2019 Category: Infectious Diseases Source Type: news
Antibiotic produced by the microbiome kills bacteria by disturbing energy metabolism
(German Center for Infection Research) A research team from the universities of T ü bingen and G ö ttingen as well as from the German Center for Infection Research has investigated the mode of action of a new class of antibiotics that is highly effective against multidrug-resistant pathogens. The so-called fibupeptides impair the energy supply to the bacterial cell, consequently causing their death. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 4, 2019 Category: Infectious Diseases Source Type: news
Civil War Plant Medicines Inhibit Multidrug-Resistant Wound Bacteria
Plants recommended as medicines during the Civil War inhibit dangerous antibiotic-resistant wound bacteria (Source: NCCAM Featured Content)
Source: NCCAM Featured Content - May 29, 2019 Category: Complementary Medicine Authors: NCCIH Source Type: news
Analysis of the challenges in implementing guidelines to prevent the spread of multidrug-resistant gram-negatives in Europe
This study reported low compliance infection prevention and control (IPC) measures and identified three areas as critical for the compliance rate: number of infection control staff, IPC dedicated educational programmes and number of clinical staff. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 29, 2019 Category: Consumer Health News Source Type: news
Role of AcrAB-TolC multidrug efflux pump in drug-resistance acquisition by plasmid transfer
Drug-resistance dissemination by horizontal gene transfer remains poorly understood at the cellular scale. Using live-cell microscopy, we reveal the dynamics of resistance acquisition by transfer of the Escherichia coli fertility factor–conjugation plasmid encoding the tetracycline-efflux pump TetA. The entry of the single-stranded DNA plasmid into the recipient cell is rapidly followed by complementary-strand synthesis, plasmid-gene expression, and production of TetA. In the presence of translation-inhibiting antibiotics, resistance acquisition depends on the AcrAB-TolC multidrug efflux pump, because it reduces tetr...
Source: ScienceNOW - May 22, 2019 Category: Science Authors: Nolivos, S., Cayron, J., Dedieu, A., Page, A., Delolme, F., Lesterlin, C. Tags: Cell Biology, Microbiology reports Source Type: news
