Chlorhexidine bathing to prevent healthcare-associated vancomycin-resistant Enterococcus infections: A cluster quasi-experimental controlled study at intensive care units, Journal of the Formosan Medical Association
Conclusion: CHG bathing is a highly effective approach to prevent VRE-HAIs at ICUs, in the context of active VRE surveillance with contact isolation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news
Unintended consequences of infection prevention and control measures during COVID-19 pandemic, American Journal of Infection Control
The impact of a multimodal infection control strategy originally designed for containment of COVID-19 on the rates of other hospital-acquired-infections (HAIs) was evaluated over a 7-month period across the largest healthcare system in Singapore. • During the COVID-19 pandemic, methicillin-resistant Staphylococcus aureus acquisition rates declined significantly, together with central-line-associated-bloodstream infection rates; likely due to increased compliance with standard precautions. • Enhanced infection control measures resulted in the unintended positive consequences of containing health care-associated respirat...
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news
Africa: TB Testing in 2020 Dropped Drastically Due to Covid-19
[The Global Fund] On World Tuberculosis Day, new data shows the COVID-19 pandemic has had a devastating impact on the fight against another deadly airborne disease: tuberculosis. Global Fund surveys in 13 countries with the highest TB burden in the world reveal that 29% fewer people were tested for TB compared to 2019. Worse, in those same countries, there were 45% fewer people tested for multidrug-resistant TB -- one of the most frightening forms of antimicrobial resistance. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 25, 2021 Category: African Health Source Type: news
Africa: Drug-Resistant Tuberculosis Trial Ends Enrolment After Positive Initial Data
[MSF] London - A trial aiming to find a better treatment for multidrug-resistant tuberculosis (MDR-TB) has stopped enrolling patients early after its independent data safety and monitoring board indicated that the regimen being studied is superior to current care, and more patient data was extremely unlikely to change the trial's outcome. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - March 24, 2021 Category: Infectious Diseases Source Type: news
Johnson & Johnson Announces Five Initiatives to Help Find the ‘Missing Millions’ of Undiagnosed People Living with Tuberculosis
NEW BRUNSWICK, N.J., 24 March 2021 – In recognition of World Tuberculosis (TB) Day, Johnson & Johnson today announced a series of new commitments and collaborations in support of global efforts to find and deliver care to the millions of adults and children living with TB who have not yet been diagnosed. Successfully identifying these people, especially those living with multidrug-resistant TB (MDR-TB), remains one of the most significant obstacles in achieving the United Nations (UN) Sustainable Development Goal of ending TB by 2030. These initiatives—together with the Global Fund to Fight AIDS, Tuberculosis and M...
Source: Johnson and Johnson - March 24, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news
Lenacapavir Effective in Multidrug Resistant HIV Lenacapavir Effective in Multidrug Resistant HIV
Some observers expressed skepticism, noting that reduced viral load may have resulted not from lenacapavir but a simultaneous switch to an optimized backbone regimen.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 12, 2021 Category: Consumer Health News Tags: HIV/AIDS News Source Type: news
Antibiotic-resistant strains of staph bacteria may be spreading between pigs raised in factory farms
(Johns Hopkins University Bloomberg School of Public Health) DNA sequencing of bacteria found in pigs and humans in rural eastern North Carolina, an area with concentrated industrial-scale pig-farming, suggests that multidrug-resistant Staphylococcus aureus strains are spreading between pigs, farmworkers, their families and community residents, and represents an emerging public health threat, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 5, 2021 Category: International Medicine & Public Health Source Type: news
Mouse study shows bacteriophage therapy could fight drug-resistant Klebsiella pneumoniae
(NIH/National Institute of Allergy and Infectious Diseases) Using viruses instead of antibiotics to tame troublesome drug-resistant bacteria is a promising strategy, known as bacteriophage or " phage therapy. " Scientists at the National Institutes of Health have used two different bacteriophage viruses individually and then together to successfully treat research mice infected with multidrug-resistant Klebsiella pneumoniae sequence type 258 (ST258). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 23, 2021 Category: International Medicine & Public Health Source Type: news
Organization of antibiotic stewardship in Europe: the way to go, Wiener medizinische Wochenschrift 171(Suppl 1): 4-8
It is more than two decades ago that a European Union conference on " The Microbial Threat " hosted by the Danish Government in Copenhagen in September 1998 issued recommendations to encourage good practice in the use of antimicrobial agents and reduce inappropriate prescribing. Essential components of those recommendations were antimicrobial teams in hospitals and the use of feedback to prescribers as well as educational activities. Two decades later, important surveillance systems on both antimicrobial resistance as well as on antibiotic consumption are functioning at the European level and in most European countries; Eu...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news
Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial, American journal of respiratory and critical care medicine 203(2): 202-210.
Rationale: Although early antimicrobial discontinuation guided by procalcitonin (PCT) has shown decreased antibiotic consumption in lower respiratory tract infections, the outcomes in long-term sepsis sequelae remain unclear. Objectives: To investigate if PCT guidance may reduce the incidence of long-term infection-associated adverse events in sepsis. Methods: In this multicenter trial, 266 patients with sepsis (by Sepsis-3 definitions) with lower respiratory tract infections, acute pyelonephritis, or primary bloodstream infection were randomized (1:1) to receive either PCT-guided discontinuation of antimicrobials or stand...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news
Incidence of Multidrug Resistant Infections in Emergency Department Patients with Suspected Sepsis, The American journal of the medical sciences 360(6): 650-655
Background: Inappropriate antibiotic therapy in sepsis is associated with poor outcomes, clinicians often provide routine coverage for multidrug resistant (MDR) bacteria. However, these regimens may contribute to problems related to antibiotic overuse. To understand the incidence and related factors of multidrug resistant bacterial infections in ED patients with sepsis, we examined how often patients with sepsis in our emergency department had MDR infections. We also explored risk factors for, and outcomes from, MDR bacterial infections.; Methods: We reviewed records of patients presenting to our emergency department (ED) ...
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news
Whole-genome sequencing of multidrug-resistant bacteria cost saving for hospitals
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - February 1, 2021 Category: Drugs & Pharmacology Source Type: news
Ibalizumab cost effective for multidrug-resistant HIV-1 infection in USA?
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - February 1, 2021 Category: Drugs & Pharmacology Source Type: news
UToledo awarded Department of Defense funding to advance promising new chemotherapy
(University of Toledo) The project relies on a unique cell death pathway to overcome the multidrug resistance that often characterizes triple negative breast cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 25, 2021 Category: International Medicine & Public Health Source Type: news
Diclofenac mitigates virulence of multidrug-resistant Staphylococcus aureus. Archives of microbiology 202(10): 2751-2760.
In conclusion, diclofenac can be used in combination with antibiotics as anti-virulence agent against MDR-MRSA which will enhance the ability of immune system to eradicate infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news
