Multidrug-resistant Malaria Outbreak Originated in Western Cambodia Multidrug-resistant Malaria Outbreak Originated in Western Cambodia

The current outbreak of multidrug-resistant malaria in Southeast Asia originated in western Cambodia soon after dihydroartemisinin-piperaquine became the first-line antimalarial drug there, according to a new genetic study.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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We reported earlier about nano-formulation of tetracycline through its entrapment within calcium-phosphate nano-particle (CPNP) and about killing of pathogenic bacterium Shigella flexnari 2a, resistant to tetracycline (and 9 other antibiotics), by the nanonized antibiotic (Tet-CPNP). Here, we report on therapeutic role of Tet-CPNP against deadly diarrheal disease ‘shigellosis’ in mice, caused by Shigella infection. Our findings revealed that occurrence of mushy-stool excretion, colon-length shortening, weight-loss and bacterial colonization in gastrointestinal tract of mice due to shigellosis was significantly ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
CONCLUSIONS: NDM-1-producing HMKP ST1764 isolates were identified; this is the first report worldwide on an outbreak of nosocomial infection caused by these isolates. Effective surveillance and strict infection control strategies should be implemented to prevent CR-HMKP dissemination. PMID: 30430779 [PubMed - in process]
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
Authors: Bae E, Kim CK, Jang JH, Sung H, Choi Y, Kim MN Abstract BACKGROUND: No study has examined the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in Korean veterans' hospitals. We investigated the microbiological and clinical epidemiology of S. aureus bacteremia at the central Veterans Health Services (VHS) hospital in Korea. METHODS: Patients with S. aureus bacteremia were consecutively enrolled from February to August 2015. Bacteremia was classified as hospital-acquired (HA), community-onset healthcare-associated (COHA), or community-acquired (CA). MRSA bacteremia risk facto...
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
An 11th child has died in less than four weeks at a New Jersey rehabilitation center, one of 34 young patients with compromised immune systems to have been infected by a viral outbreak, state health officials said on Friday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Publication date: Available online 16 November 2018Source: Veterinary MicrobiologyAuthor(s): Mengmeng Yu, Lixiao Xing, Fangfang Chang, Yuanling Bao, Suyan Wang, Xijun He, Jingfei Wang, shida Wang, Yongzhen Liu, Muhammad Farooque, Qing Pan, Yongqiang Wang, Li Gao, Xiaole Qi, Altaf Hussain, Kai Li, Changjun Liu, Yanping Zhang, Hongyu Cui, Xiaomei WangAbstractAvian metapneumovirus (aMPV), which has been reported in many countries, causes an acute upper respiratory tract disease in chickens and turkeys. Although aMPV was first detected in China in 1999, there has been no further effort to isolate and characterize the aMPV subt...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
The salmonella outbreak in raw turkey rages on just a week before Turkey Day, forcing the US Department of Agriculture to recall over 91,000 lbs of Jennie-O ground turkey - and more may be contaminated.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Li W, Deng W, Xie J Abstract Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality globally, with nearly 10.4 million new cases of incidence and over 1.7 million deaths annually. Drug-resistant M. tuberculosis strains, especially multidrug-resistant or extensively drug-resistant strains, have further intensified the problem associated with tuberculosis control. Host-directed therapy is a promising alternative for tuberculosis control. IL-32 is increasingly recognized as an important host molecule against tuberculosis. In this review, we highlight the proinfl...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
FRIDAY, Feb. 2, 2018 -- An outbreak of multidrug-resistant malaria in southeast Asia likely stems from two mutations of the malaria-causing parasite that combined a decade ago, according to new research. The parasite and mutations, carried by...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The KEL1/PLA1 co-lineage emerged in the same year that dihydroartemisinin –piperaquine became the first-line antimalarial drug in western Cambodia and spread rapidly thereafter, displacing other artemisinin-resistant parasite lineages. These findings have important implications for management of the global health risk associated with the current outbreak of multidrug-re sistant malaria in southeast Asia.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Articles Source Type: research
Credit: BigstockBy Martin KhorPENANG, Malaysia, Dec 4 2017 (IPS)The growing crisis of antibiotic resistance is catching the attention of policy makers, but not at a rate enough to tackle it.More diseases are affected by resistance, meaning the bacteria cannot be killed even if different drugs are used on some patients, who then succumb.We are staring at a future in which antibiotics don’t work, and many of us or our children will not be saved from TB, cholera, deadly forms of dysentery, and germs contracted during surgery.Martin Khor, Executive Director of the South Centre, a think tank for developing countries, base...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Global Global Governance Headlines Health Poverty & SDGs Regional Categories TerraViva United Nations Source Type: news
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