Multidrug-resistant Malaria Outbreak Originated in Western Cambodia Multidrug-resistant Malaria Outbreak Originated in Western Cambodia

The current outbreak of multidrug-resistant malaria in Southeast Asia originated in western Cambodia soon after dihydroartemisinin-piperaquine became the first-line antimalarial drug there, according to a new genetic study.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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Publication date: Available online 16 August 2018Source: Journal of Theoretical BiologyAuthor(s): Marina Voinson, Alexandra Alvergne, Sylvain Billiard, Charline SmadiAbstractMost emerging human infectious diseases have an animal origin. While zoonotic diseases originate from a reservoir, most theoretical studies have principally focused on single-host processes, either exclusively humans or exclusively animals, without considering the importance of animal to human transmission (i.e. spillover transmission) for understanding the dynamics of emerging infectious diseases. Here we aim to investigate the importance of spillover...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
A report published on Wednesday found that a deadly tick-borne illness, Rocky Mountain spotted fever, is spreading from Mexico to the US thanks to a new tick that spreads a more virulent strain.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 16 August 2018Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Prasenjit Dhar, Aneesh Thakur, Rajesh Kumar Asrani, Vipin Katoch, Mandeep SharmaAbstractFowl adenovirus-4 (FAdV-4) causes hydropericardium syndrome (HPS) in poultry worldwide. An understanding of viral structural protein composition is important for developing novel immunodiagnostics and immunoprophylactics. Here we report isolation, culture, molecular and protein profile of FAdV-4 isolates recovered from HPS outbreaks in chicken in the states of Himachal Pradesh and Tamil Nadu in India. We perfor...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
A recent outbreak of illness at a Chipotle Mexican Grill restaurant in Ohio that affected hundreds of people was caused by a type of bacteria, local health officials said on Thursday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Conclusion: Our study demonstrates that PCI29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 and enhances the anti-tumor efficacy of substrate chemotherapeutic agents, This findings encourages the development of combinational chemotherapy for the treatment of ABCG2- overexpressing cancer patients.Cell Physiol Biochem 2018;48:2302 –2317
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
CONCLUSION: We detected that all outbreak-related isolates contained the same OXA-type carbapenemase genes. Phenotypic similarity, based on the analysis of antimicrobial susceptibility patterns, was correlated with genotypic similarity. These results suggest that monitoring antimicrobial resistance patterns with daily culture surveillance follow-ups, coupled with the use of amplification based methods to detect that clonal relationships are important for the early identification of outbreaks and rapid deployment of proper countermeasures to halt the spread of the causative agent. PMID: 30106413 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
150 years after Semmelweis advised fellow physicians to sanitize their hands to mitigate the effect of infections, the maintenance of hygiene is still a widespread problem in hospitals and the source of healthcare-associated infections. Now, technological solutions line up against microorganisms, bacteria, and fungi. Here are a few examples. 1 in 9 in-patients will die due to infection According to the US Center for Disease Control, studies show that on average, healthcare providers clean their hands less than half of the times they should. This significantly contributes to the spread of healthcare-associated infections (H...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Healthcare Design Medical Professionals Policy Makers clean digital digital health future HAI healthcare-associated infection hygiene Medicine robot robotics sensors technology trackers wearable Source Type: blogs
FRIDAY, Feb. 2, 2018 -- An outbreak of multidrug-resistant malaria in southeast Asia likely stems from two mutations of the malaria-causing parasite that combined a decade ago, according to new research. The parasite and mutations, carried by...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The KEL1/PLA1 co-lineage emerged in the same year that dihydroartemisinin –piperaquine became the first-line antimalarial drug in western Cambodia and spread rapidly thereafter, displacing other artemisinin-resistant parasite lineages. These findings have important implications for management of the global health risk associated with the current outbreak of multidrug-re sistant malaria in southeast Asia.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Articles Source Type: research
Credit: BigstockBy Martin KhorPENANG, Malaysia, Dec 4 2017 (IPS)The growing crisis of antibiotic resistance is catching the attention of policy makers, but not at a rate enough to tackle it.More diseases are affected by resistance, meaning the bacteria cannot be killed even if different drugs are used on some patients, who then succumb.We are staring at a future in which antibiotics don’t work, and many of us or our children will not be saved from TB, cholera, deadly forms of dysentery, and germs contracted during surgery.Martin Khor, Executive Director of the South Centre, a think tank for developing countries, base...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Global Global Governance Headlines Health Poverty & SDGs Regional Categories TerraViva United Nations Source Type: news
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