Multidrug-resistant Malaria Outbreak Originated in Western Cambodia Multidrug-resistant Malaria Outbreak Originated in Western Cambodia

The current outbreak of multidrug-resistant malaria in Southeast Asia originated in western Cambodia soon after dihydroartemisinin-piperaquine became the first-line antimalarial drug there, according to a new genetic study.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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Publication date: Available online 26 May 2018 Source:The Brazilian Journal of Infectious Diseases Author(s): Lisia Miglioli Galvão, Anna Paula Romero de Oliveira, Aline Santos Ibanês, Jussimara Monteiro, Fernanda Inoue, Daniel Chagas Dantas, Flavio Sanchez, Daniel Wagner Santos, Cely Saad Abboud Herein we report a fatal case of donor-derived transmission of XDR-resistant carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) in cardiac transplantation. A 59-year-old male patient with non-obstructive hypertrophic cardiomyopathy underwent heart transplantation. On day 5 post-operation, blood cultures from the ...
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate–binding cassette (ABC) transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods Forty-two targeted variants in seven genes were genotyped in 54 participants using Sequenom MassARRAY system to investigate their association with major pharmacokinetic parameters of CK and its metabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using the AutoDock Vina program. Results ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK and decreased exposure of 20(...
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
FRIDAY, Feb. 2, 2018 -- An outbreak of multidrug-resistant malaria in southeast Asia likely stems from two mutations of the malaria-causing parasite that combined a decade ago, according to new research. The parasite and mutations, carried by...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The KEL1/PLA1 co-lineage emerged in the same year that dihydroartemisinin –piperaquine became the first-line antimalarial drug in western Cambodia and spread rapidly thereafter, displacing other artemisinin-resistant parasite lineages. These findings have important implications for management of the global health risk associated with the current outbreak of multidrug-re sistant malaria in southeast Asia.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Articles Source Type: research
Credit: BigstockBy Martin KhorPENANG, Malaysia, Dec 4 2017 (IPS)The growing crisis of antibiotic resistance is catching the attention of policy makers, but not at a rate enough to tackle it.More diseases are affected by resistance, meaning the bacteria cannot be killed even if different drugs are used on some patients, who then succumb.We are staring at a future in which antibiotics don’t work, and many of us or our children will not be saved from TB, cholera, deadly forms of dysentery, and germs contracted during surgery.Martin Khor, Executive Director of the South Centre, a think tank for developing countries, base...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Global Global Governance Headlines Health Poverty & SDGs Regional Categories TerraViva United Nations Source Type: news
Abstract In November 2013, a Plasmodium falciparum malaria outbreak of 11 cases occurred in Cusco, southern Peru, where falciparum malaria had not been reported since 1946. Although initial microscopic diagnosis reported only Plasmodium vivax infection in each of the specimens, subsequent examination by the national reference laboratory confirmed P. falciparum infection in all samples. Molecular typing of four available isolates revealed identity to the B-variant (BV1) strain that was responsible for a malaria outbreak in Tumbes, northern Peru, between 2010 and 2012. The P. falciparum BV1 strain is multidrug resis...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
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