Antibiotic resistance and genomic characterization of Mycobacterium abscessus complex isolates from patients with pulmonary tuberculosis in Iran: A multi-center study (2010-2021)
Acta Microbiol Immunol Hung. 2024 Jan 29. doi: 10.1556/030.2024.02169. Online ahead of print.ABSTRACTOne hundred and eighteen sputum specimens suspected of Mycobacterium abscessus infection were collected. Species level identification of M. abscessus was performed by rpoB sequencing. Clonality analysis was done by multilocus sequence typing (MLST) for M. abscessus. Antibiotic susceptibility testing was performed for clarithromycin, amikacin, ciprofloxacin and moxifloxacin. Altogether 128 isolates were obtained and were subjected to rpoB gene sequencing for definite identification. Among them 59 were identified as M. absces...
Source: Acta Microbiologica et Immunologica Hungarica - January 29, 2024 Category: Microbiology Authors: Mohammad Hashemzadeh Aram Asareh Zadegan Dezfuli AzarDokht Khosravi Nazanin Ahmad Khosravi Morteza Saki Source Type: research
Clofazimine-associated enteropathy
A 36-year-old man presented to the gastroenterology department because he had experienced intermittent abdominal pain for 1 year. He had received a diagnosis of multidrug-resistant pulmonary tuberculosis 2 years earlier and had received a drug regimen containing clofazimine, linezolid, protionamide, cycloserine, pyrazinamide, and moxifloxacin for 19 months. The abdominal pain occurred after he had been taking clofazimine for 7 months. Physical examination showed skin darkening. Laboratory results showed no abnormalities. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - January 29, 2024 Category: Gastroenterology Authors: Jixin Zhang, Jinpei Dong Tags: At the focal point Source Type: research
Recording ten-fold larger IKr conductances with automated patch clamping using equimolar Cs+ solutions
Conclusion: Using equimolar Cs+ instead of K+ for IhERG measurements in an automated patch-clamp system gives rise to a new method by which, for example, quick scans can be performed on effects of drugs on hERG currents. This application is specifically relevant when such experiments are performed using cells which express small IKr current densities in combination with small membrane capacitances. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 24, 2024 Category: Physiology Source Type: research
Effect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and Lung in Male and Female Rats
CONCLUSION: MFX was highly transferred to the lung tissue and this passage was remarkably higher in male rats. However, DEX administration increased the plasma concentration of MFX in both male and female rats but did not change its passage to the lung. However, there is a need for a more detailed investigation of the difference in the pharmacokinetics of MFX in male and female rats.PMID:38258775 | DOI:10.2174/0113892002282271231219044508 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 23, 2024 Category: Drugs & Pharmacology Authors: Teslime Erdogan Halis Oguz Orhan Corum Source Type: research
No Influence of Asundexian on Cardiac Repolarization
AbstractInhibition of activated factor XI reduces thrombogenesis while maintaining physiological hemostasis, with the expectation of reduced bleeding risk compared with standard of care in the clinical setting. Asundexian (BAY 2433334), an activated factor XI inhibitor, is in clinical development for the prevention of thromboembolic events. The effect of asundexian and its plasma metabolite M10 on cardiac repolarization and potential interactions with the hNav1.5 sodium, hCav1.2 calcium, and human ether- à-go-go-related gene (hERG) potassium channels was investigated in vitro. Additionally, asundexian effects on cardiac p...
Source: Clinical Pharmacology in Drug Development - January 16, 2024 Category: Drugs & Pharmacology Authors: Christine Brase,
Friederike Kanefendt,
Stephanie Loewen,
Herbert Himmel,
Sebastian Schmitz Tags: Original Article Source Type: research
A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis
Conclusion: The framework we developed requires limited drug- and species-specific information to reconstruct accurate PK dynamics, delivering a unified viewpoint on anti-TB drug distribution at the site-of-action and a flexible fit-for-purpose tool to accelerate model-informed drug design pipelines and facilitate translation into the clinic. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 4, 2024 Category: Drugs & Pharmacology Source Type: research
Microbiological analysis and antibiotic selection strategy in neck abscesses among patients with diabetes mellitus
ConclusionNeck abscess patients with diabetes have distinct clinical features. Therefore, it is crucial to pay attention to these clinical features and manage them accordingly during the treatment process. Empirical antibiotic treatment should be tailored to individual patient groups. Sulfamethoxazole-methoxazole is recommended for neck abscess patients with diabetes, while ceftriaxone or moxifloxacin is recommended for those without diabetes. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - December 26, 2023 Category: ENT & OMF Source Type: research
Ribotypes and antimicrobial susceptibility profiles of clinical Clostridioides difficile isolates: A multicenter, laboratory-based surveillance in Taiwan, 2019-2021
CONCLUSIONS: Vancomycin, fidaxomicin, and metronidazole remain in vitro effective against clinical C. difficile isolates in Taiwan. The reservoirs and genetic relatedness of two major RTs with zoonotic potentials, RT 078/126 and 014/020, warrant further investigations.PMID:38135646 | DOI:10.1016/j.jmii.2023.12.004 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - December 22, 2023 Category: Microbiology Authors: Chin-Shiang Tsai Po-Liang Lu Min-Chi Lu Tai-Chin Hsieh Wei-Ting Chen Jann-Tay Wang Wen-Chien Ko Source Type: research
Ribotypes and antimicrobial susceptibility profiles of clinical Clostridioides difficile isolates: A multicenter, laboratory-based surveillance in Taiwan, 2019-2021
CONCLUSIONS: Vancomycin, fidaxomicin, and metronidazole remain in vitro effective against clinical C. difficile isolates in Taiwan. The reservoirs and genetic relatedness of two major RTs with zoonotic potentials, RT 078/126 and 014/020, warrant further investigations.PMID:38135646 | DOI:10.1016/j.jmii.2023.12.004 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - December 22, 2023 Category: Microbiology Authors: Chin-Shiang Tsai Po-Liang Lu Min-Chi Lu Tai-Chin Hsieh Wei-Ting Chen Jann-Tay Wang Wen-Chien Ko Source Type: research
Ribotypes and antimicrobial susceptibility profiles of clinical Clostridioides difficile isolates: A multicenter, laboratory-based surveillance in Taiwan, 2019-2021
CONCLUSIONS: Vancomycin, fidaxomicin, and metronidazole remain in vitro effective against clinical C. difficile isolates in Taiwan. The reservoirs and genetic relatedness of two major RTs with zoonotic potentials, RT 078/126 and 014/020, warrant further investigations.PMID:38135646 | DOI:10.1016/j.jmii.2023.12.004 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - December 22, 2023 Category: Microbiology Authors: Chin-Shiang Tsai Po-Liang Lu Min-Chi Lu Tai-Chin Hsieh Wei-Ting Chen Jann-Tay Wang Wen-Chien Ko Source Type: research
Ribotypes and antimicrobial susceptibility profiles of clinical Clostridioides difficile isolates: A multicenter, laboratory-based surveillance in Taiwan, 2019-2021
CONCLUSIONS: Vancomycin, fidaxomicin, and metronidazole remain in vitro effective against clinical C. difficile isolates in Taiwan. The reservoirs and genetic relatedness of two major RTs with zoonotic potentials, RT 078/126 and 014/020, warrant further investigations.PMID:38135646 | DOI:10.1016/j.jmii.2023.12.004 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - December 22, 2023 Category: Microbiology Authors: Chin-Shiang Tsai Po-Liang Lu Min-Chi Lu Tai-Chin Hsieh Wei-Ting Chen Jann-Tay Wang Wen-Chien Ko Source Type: research
Bilateral Acute Iris Transillumination After Systemic Moxifloxacin Treatment
This case report discusses a diagnosis of bilateral acute iris transillumination secondary to systemic antibiotics in a patient who presented with persistent bilateral photophobia. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - December 21, 2023 Category: Opthalmology Source Type: research
Clinical characteristics and antimicrobial susceptibility of Fusobacterium species isolated over 10 years at a Japanese university hospital
CONCLUSION: We show a link between Fusobacterium species and solid organ malignancies. We observed resistance to penicillin, cefmetazole, clindamycin, and moxifloxacin, warranting caution in their clinical use. This study offers valuable insights for managing Fusobacterium infections and guiding empirical treatments.PMID:38112966 | DOI:10.1007/s10096-023-04734-2 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - December 19, 2023 Category: Cancer & Oncology Authors: Nobuaki Mori Akiko Nakamura Jun Hirai Nobuhiro Asai Yuichi Shibata Mina Takayama Yuzuka Kawamoto Narimi Miyazaki Daisuke Sakanashi Tomoko Ohno Atsuko Yamada Hiroyuki Suematsu Isao Koita Sumie Chida Toshiaki Ohta Hiroshige Mikamo Source Type: research
Clinical characteristics and antimicrobial susceptibility of Fusobacterium species isolated over 10 years at a Japanese university hospital
CONCLUSION: We show a link between Fusobacterium species and solid organ malignancies. We observed resistance to penicillin, cefmetazole, clindamycin, and moxifloxacin, warranting caution in their clinical use. This study offers valuable insights for managing Fusobacterium infections and guiding empirical treatments.PMID:38112966 | DOI:10.1007/s10096-023-04734-2 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - December 19, 2023 Category: Cancer & Oncology Authors: Nobuaki Mori Akiko Nakamura Jun Hirai Nobuhiro Asai Yuichi Shibata Mina Takayama Yuzuka Kawamoto Narimi Miyazaki Daisuke Sakanashi Tomoko Ohno Atsuko Yamada Hiroyuki Suematsu Isao Koita Sumie Chida Toshiaki Ohta Hiroshige Mikamo Source Type: research
Clinical characteristics and antimicrobial susceptibility of Fusobacterium species isolated over 10 years at a Japanese university hospital
ConclusionWe show a link betweenFusobacterium species and solid organ malignancies. We observed resistance to penicillin, cefmetazole, clindamycin, and moxifloxacin, warranting caution in their clinical use. This study offers valuable insights for managingFusobacterium infections and guiding empirical treatments. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 19, 2023 Category: Microbiology Source Type: research
