Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Mycoplasma genitalium: Key Information for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):297-310. doi: 10.1016/j.mcna.2023.07.004. Epub 2023 Sep 14.ABSTRACTMycoplasma genitalium (MG) is an emerging sexually transmitted infection, which appears to be a cause of urethritis and cervicitis and has been associated with pelvic inflammatory disease (PID), epididymitis, proctitis, infertility, complications during pregnancy, and human immunodeficiency virus (HIV) transmission. Three Food and Drug Administration (FDA) approved tests are available. Testing should be focused to avoid inappropriate antibiotic use. The Center of Disease Control and Prevention (CDC) guidelines recommend te...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Oluyomi A Obafemi Sarah E Rowan Masayo Nishiyama Karen A Wendel Source Type: research

Prevalence of antibiotic resistance in clinical isolates of < em > Mycobacterium kansasii < /em > : a systematic review and meta-analysis
Expert Rev Anti Infect Ther. 2024 Jan 31:1-11. doi: 10.1080/14787210.2024.2313051. Online ahead of print.ABSTRACTINTRODUCTION: The prevalence of diseases caused by non-tuberculous mycobacteria (NTM), including M. kansasii, is increasing, necessitating further information to guide prevention, control, and treatment strategies.AREAS COVERED: A comprehensive analysis of articles published until February 2023 was conducted on PubMed, Web of Science, and Scopus databases to investigate antibiotic resistance in M. kansasii species. Stata software version 17 was employed for all analyses.EXPERT OPINION: A total of 1647 articles w...
Source: Expert Review of Anti-Infective Therapy - January 31, 2024 Category: Infectious Diseases Authors: Negar Narimisa Forough Goodarzi Narjess Bostanghadiri Faramarz Masjedian Jazi Source Type: research

Predicting valuable missense variants with AlphaMissense in a multiple pulmonary infection patient
Clinical course of the patient. Sulfamethoxazole and ceftriaxone (day 12 –17), linezolid (day 18), moxifloxacin (day 136–140), meropenem (day 141–161), faropenem and rifampicin (day 161). (A, B) Contrast-enhanced CT of the pulmonary at day 65. (C, D) Contrast-enhanced CT of the pulmonary at day 132. Key Clinical MessageAlphaMissense is proficient in predicting the clinical classification of missense variants. we utilized AlphaMissense to find disease-relevant variants within a polymicrobial pulmonary infection case. Exome sequencing was performed in this patient, and AlphaMissense and Phenolyzer were combined to inve...
Source: Clinical Case Reports - January 30, 2024 Category: General Medicine Authors: Tianyuan Wang, Jindi Ma, Yuan Shu, Bao Hong, Zhouhan Wang, Yingfeng Lu, Xiaopeng Yu, Xi Huang, Yimin Zhang Tags: CASE REPORT Source Type: research

Concentration ‐QTcF Modeling of Icenticaftor from a Randomized, Placebo‐ and Positive‐Controlled Thorough QT Study in Healthy Participants
AbstractIcenticaftor (QBW251) is a potentiator of the cystic fibrosis transmembrane receptor. Based on its mechanism of action, icenticaftor is expected to provide benefits in patients with chronic obstructive pulmonary disease by restoring mucociliary clearance, which would eventually lead to a reduction of bacterial colonization and related inflammatory cascade. A placebo- and positive-controlled, 4-way crossover thorough QT study was conducted in 46 healthy participants with the objective to assess the effect of therapeutic (300  mg twice daily for 6 days) and supratherapeutic (750 mg twice daily for 6 days) oral dose...
Source: Clinical Pharmacology in Drug Development - January 30, 2024 Category: Drugs & Pharmacology Authors: Ganesh R. Iyer, Borje Darpo, Hongqi Xue, Jean Lecot, Julia Zack, Lidiya Bebrevska, Wendy Weis, Ieuan Jones, Anton Drollmann Tags: Original Article Source Type: research