Recording ten-fold larger IKr conductances with automated patch clamping using equimolar Cs+ solutions

Conclusion: Using equimolar Cs+ instead of K+ for IhERG measurements in an automated patch-clamp system gives rise to a new method by which, for example, quick scans can be performed on effects of drugs on hERG currents. This application is specifically relevant when such experiments are performed using cells which express small IKr current densities in combination with small membrane capacitances.
Source: Frontiers in Physiology - Category: Physiology Source Type: research