Solving the peroxisome puzzle
(University of California - Santa Barbara) The ability to make membrane-bound organelles is a defining characteristic of eukaryotic cells -- cells that constitute the bodies of all animals, plants and fungi on Earth. Membranes create enclosures that provide specialized environments for certain structures and their functions, such as the nuclei that store genetic information, or the mitochondria that produce energy for the cell. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 27, 2021 Category: Biology Source Type: news
Proteomics reveals how exercise increases the efficiency of muscle energy production
(University of Copenhagen - The Faculty of Health and Medical Sciences) By applying mass spectrometry, scientists at the University of Copenhagen provide some of the most detailed data on how mitochondrial proteins cluster into supercomplexes - a process that makes mitochondria more efficient at producing energy. The findings, which were published in Cell Reports, is a precious resource for the scientific community, especially those tackling mitochondrial adaptations to exercise training or mitochondrial diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 26, 2021 Category: International Medicine & Public Health Source Type: news
Too much salt suppresses phagocytes
(Max Delbr ü ck Center for Molecular Medicine in the Helmholtz Association) Small changes of sodium in the blood reduce the amount of energy produced in the mitochondria - the power plants of our cells. This has consequences for immune cells. An international research team led by MDC scientists hasdiscovered the mechanism behind this phenomenon and published their findings in the journal Circulation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 30, 2021 Category: International Medicine & Public Health Source Type: news
A gene finding links severe canine juvenile epilepsy to mitochondrial dysfunction
(University of Helsinki) In a study conducted at the University of Helsinki, researchers found a cause for severe epilepsy resulting in death in Parson Russell Terrier puppies at a few months of age. A change in the PITRM1 gene can lead to a dysfunction of mitochondria, the cellular energy pumps. Concurrently, amyloid-β accumulation and widespread neurodegeneration associated with Alzheimer's disease were identified in the puppies' brains. Changes to the PITRM1 gene in humans also cause a severe but slowly progressing brain disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 20, 2021 Category: International Medicine & Public Health Source Type: news
DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission
The RIG-I–like receptor (RLR) signaling pathway is pivotal for innate immunity against invading viruses, and dysregulation of this molecular cascade has been linked to various diseases. Here, we identified dimethylarginine dimethylaminohydrolase 2 (DDAH2) as a potent regulator of the RLR-mediated antiviral response in human and mouse. Overexpression of DDAH2 attenuated RLR signaling, whereas loss of DDAH2 function enhanced RLR signaling and suppressed viral replication ex vivo and in mice. Upon viral infection, DDAH2 relocated to mitochondria, where it induced the production of nitric oxide (NO) and the activation of...
Source: Signal Transduction Knowledge Environment - April 13, 2021 Category: Science Authors: Huang, S., Li, Z., Wu, Z., Liu, C., Yu, M., Wen, M., Zhang, L., Wang, X. Tags: STKE Research Articles Source Type: news
Researchers awarded $500,000 to test novel strategies using mitochondria therapy
(University of Tennessee Health Science Center) Researchers from the University of Tennessee Health Science Center have received a $500,000 grant over three years from the Department of Defense to test a novel strategy using mitochondria transplantation therapy for restoration of neuromuscular structure and function after injury. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 12, 2021 Category: International Medicine & Public Health Source Type: news
Metabolic changes in fat tissue in obesity associated with adverse health effects
(University of Helsinki) A twin study recently completed at the University of Helsinki indicates that the machinery responsible for energy handling in fat tissue is working poorly in obesity. In the study, a clear reduction was seen in the activity of mitochondrial genes in obesity in fat tissue, while similar genome-level change in muscle mitochondria was minor. A link with adverse health effects was identified in the mitochondria of fat tissue only. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 9, 2021 Category: Biology Source Type: news
Can HIIT Exercise Be Bad For Your Health?
A new study hints that excessive HIIT may harm your mitochondria, the energy generators found in every cell of your body. (Source: NYT Health)
Source: NYT Health - March 24, 2021 Category: Consumer Health News Authors: Gretchen Reynolds Tags: Exercise Mitochondria Muscles Cell Metabolism (Journal) Karolinska Institute Source Type: news
Too Much High-Intensity Exercise May Be Bad for Your Health
A new study hints that excessive HIIT may harm your mitochondria, the energy generators found in every cell of your body. (Source: NYT Health)
Source: NYT Health - March 24, 2021 Category: Consumer Health News Authors: Gretchen Reynolds Tags: Exercise Mitochondria Muscles Cell Metabolism (Journal) Karolinska Institute Source Type: news
Autoimmunity origins may lie in defective mitochondria
<div class="rxbodyfield">NIEHS scientists led a gene study that suggests accumulation of damaged mitochondria activated immune system of mice, similar to Sjogren’s syndrome.</div> (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - March 3, 2021 Category: Environmental Health Source Type: news
Messaging by mitochondria
Intercellular mitochondrial transfer promotes metabolic homeostasis and stimulates wound healing. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 2, 2021 Category: Science Authors: Wong, W. Tags: STKE Editors ' Choice Source Type: news
New research on mitochondrial function can play significant part in serious disease
(Karolinska Institutet) Disorders of the cells' energy supply can cause a number of serious diseases, but also seem to be connected to ageing. More research is needed on mitochondrial function to find future treatments. A new study involving researchers at Karolinska Institutet shows how an important molecule inside the mitochondria affects their function in mice and fruit flies. The study, which is published in Science Advances, adds valuable knowledge on formerly relatively unexplored protein modifications. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 19, 2021 Category: Cancer & Oncology Source Type: news
Electron cryo-microscopy sheds light on how bioenergy makers are made in our body
(Science For Life Laboratory) Scientists uncover how the body's energy makers are made. A new paper published in Science by Alexey Amunts' laboratory with an international team of researchers reports the molecular mechanism of membrane-tethered protein synthesis in mitochondria. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 18, 2021 Category: Biology Source Type: news
A glimpse into the formation of mitoribosome
(Science For Life Laboratory) SciLifeLab Fellow Alexey Amunts and his team together with researchers from the Czech Academy of Sciences report an assembly intermediate of the ribosome in mitochondria. It reveals 22 associated factors that cooperatively organize the biogenesis process. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 16, 2021 Category: Biology Source Type: news
Study helps understand why kids of obese mothers may be susceptible to metabolic diseases
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) The phenomenon may be associated with a deficiency of the protein mitofusin-2 in the mother's eggs, which affects the shape and functioning of mitochondria. The finding was based on experiments with mice conducted at the Federal University of S ã o Carlos and reported in the journalMolecular Human Reproduction. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 26, 2021 Category: Biology Source Type: news
