Medical News Today: Cancer: Scientists reveal how to boost radiotherapy
Scientists reveal that targeting a pathway in cancer cells that controls the motion of their mitochondria could make them more yielding to radiotherapy. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 14, 2018 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Big data studies scrutinize links between fatty liver disease and how cells make energy
(American Society for Biochemistry and Molecular Biology) Three recent studies investigate changes in mitochondria, the cell's energy producers, as fatty liver disease (NAFLD) progresses to steatohepatosis (NASH). The first two studies illuminate how mitochondrial energy production stutters and fails; the third describes how changes to the liver during disease progression affect the organ's use of nutrients to produce energy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 14, 2018 Category: International Medicine & Public Health Source Type: news
ER-SURF protein import into mitochondria
(Source: ScienceNOW)
Source: ScienceNOW - September 13, 2018 Category: Science Authors: Hurtley, S. M. Tags: Biochemistry, Cell Biology twis Source Type: news
An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast
In this study, we used a genome-wide screen in yeast and identified factors critical for the intracellular sorting of the mitochondrial inner membrane protein Oxa1. The screen uncovered an unexpected path, termed ER-SURF, for targeting of mitochondrial membrane proteins. This pathway retrieves mitochondrial proteins from the ER surface and reroutes them to mitochondria with the aid of the ER-localized chaperone Djp1. Hence, cells use the expanse of the ER surfaces as a fail-safe to maximize productive mitochondrial protein targeting. (Source: ScienceNOW)
Source: ScienceNOW - September 13, 2018 Category: Science Authors: Hansen, K. G., Aviram, N., Laborenz, J., Bibi, C., Meyer, M., Spang, A., Schuldiner, M., Herrmann, J. M. Tags: Biochemistry, Cell Biology reports Source Type: news
Mitochondria come together to kill cancer cells
(Hokkaido University) Uncovered details of a molecular pathway in cancer cells could lead to improved treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 12, 2018 Category: Cancer & Oncology Source Type: news
Changes in mitochondrial DNA control how nuclear DNA mutations are expressed in cardiomyopathy
(Children's Hospital of Philadelphia) Differences in the DNA within the mitochondria, the energy-producing structures within cells, can determine the severity and progression of heart disease caused by a nuclear DNA mutation. When combined with a mutation in nuclear DNA in animals, one mitochondrial DNA variant greatly worsened heart disease, while a different variant had a protective effect. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 11, 2018 Category: International Medicine & Public Health Source Type: news
Matter: The ‘ Zombie Gene ’ That May Protect Elephants From Cancer
With such enormous bodies, elephants should be particularly prone to tumors. But an ancient gene in their DNA, somehow resurrected, seems to shield the animals. (Source: NYT Health)
Source: NYT Health - August 14, 2018 Category: Consumer Health News Authors: CARL ZIMMER Tags: Genetics and Heredity Elephants Proteins DNA (Deoxyribonucleic Acid) Mitochondria Cancer Mammals Cell Reports (Journal) University of Chicago Lynch, Vincent J Schiffman, Joshua D Source Type: news
MSU scientists unraveled the influence of aging on kidneys regeneration ability
(Lomonosov Moscow State University) A group of researchers from MSU under the supervision of Professor Dmitry Zorov and Professor Egor Plotnikov studied the effect of aging on key cell processes, such as autophagy, the functions of mitochondria, and response to oxidative stress. The scientists also suggested advanced methods for treating kidney failure. The research was supported with a grant provided by Russian Science Foundation (RSF). The results of the study were published in the Cell Cycle journal. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 10, 2018 Category: International Medicine & Public Health Source Type: news
New theory may explain cause of depression and improve treatments
(Frontiers) Researchers suggest dysfunction in mitochondria -- the main source of energy for cells -- may be the root cause of depression. The finding brings new insight to long-held theories of the causes of depression and could lead to the development of novel and more effective antidepressant drugs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 9, 2018 Category: International Medicine & Public Health Source Type: news
Medical News Today: Cellular aging halted by hydrogen sulfide gas
New compounds that deliver gas to mitochondria appear to slow cellular aging. By tinkering with DNA machinery, the drugs boost cellular energy production. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 7, 2018 Category: Consumer Health News Tags: Seniors / Aging Source Type: news
Scientists Rid Mice of Wrinkles, Hair Loss
MONDAY, July 23, 2018 -- It ' s only worked in mice so far, but scientists report a finding that might pave a path to erase the signs of aging in humans.
In the new study, the researchers focused on the function of mitochondria, the powerhouses of... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 23, 2018 Category: General Medicine Source Type: news
Genetic researchers reverse signs of ageing in mice in 'unprecedented' study
Researchers at the University of Alabama in Birmingham used an antibiotic to cause ageing by making the mitochondria within cells dysfunction before reversing it again. (Source: the Mail online | Health)
Source: the Mail online | Health - July 22, 2018 Category: Consumer Health News Source Type: news
the healing edge: Dying Organs Restored to Life in Novel Experiments
An unusual transplant may revive tissues thought to be hopelessly damaged, including the heart and brain. (Source: NYT Health)
Source: NYT Health - July 10, 2018 Category: Consumer Health News Authors: GINA KOLATA Tags: Transplants Babies and Infants Heart Mitochondria Surgery and Surgeons Tissue (Human) Deaths (Fatalities) Boston Children's Hospital Source Type: news
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity
Mitochondria are integral to cellular energy metabolism and ATP production and are involved in regulating many cellular processes. Mitochondria produce reactive oxygen species (ROS), which not only can damage cellular components but also participate in signal transduction. The kinase ATM, which is mutated in the neurodegenerative, autosomal recessive disease ataxia-telangiectasia (A-T), is a key player in the nuclear DNA damage response. However, ATM also performs a redox-sensing function mediated through formation of ROS-dependent disulfide-linked dimers. We found that mitochondria-derived hydrogen peroxide promoted ATM d...
Source: Signal Transduction Knowledge Environment - July 10, 2018 Category: Science Authors: Zhang, Y., Lee, J.-H., Paull, T. T., Gehrke, S., DAlessandro, A., Dou, Q., Gladyshev, V. N., Schroeder, E. A., Steyl, S. K., Christian, B. E., Shadel, G. S. Tags: STKE Research Articles Source Type: news
Energizing eggs with a patient's own mitochondria offers no benefit in assisted reproduction
(European Society of Human Reproduction and Embryology) A controversial technique of energizing eggs to improve their quality in assisted reproduction has been shown in an experimental randomized trial to offer no benefit in terms of pregnancy or live birth rate. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 3, 2018 Category: International Medicine & Public Health Source Type: news
