Muscle weakness after sepsis linked to mitochondrial dysfunction
(eLife) Damage to energy-producing mitochondria may underlie prolonged muscle weakness following a sepsis-like condition in mice, according to a new study published today in eLife. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - December 10, 2019 Category: Biology Source Type: news
Mitochondria from Different Brain Cells Have Different Proteins
Organelles isolated from two types of neurons and a nonneuronal astrocyte in the mouse cerebellum showed varying levels of proteins, hinting at functional differences. (Source: The Scientist)
Source: The Scientist - December 1, 2019 Category: Science Tags: The Literature Source Type: news
Mapping the pathway to gut health in HIV and SIV infections
(University of California - Davis Health) A UC Davis study found that Lactobacillus plantarum bacteria rapidly repaired damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus. It linked chronically inflamed leaky gut to the loss of PPARα signaling and damage to mitochondria. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 19, 2019 Category: Infectious Diseases Source Type: news
Master regulator in mitochondria is critical for muscle function and repair
(Thomas Jefferson University) New study identifies how loss of mitochondrial protein MICU1 disrupts calcium balance and causes muscle atrophy and weakness. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 14, 2019 Category: Biology Source Type: news
Mitocellular communication: Shaping health and disease
Throughout the animal kingdom, mitochondria are the only organelles that retain their own genome and the transcription and translation machineries that are all essential for energy harvesting. Mitochondria have developed a complex communication network, allowing them to stay in tune with cellular needs and nuclear transcriptional programs and to alleviate mitochondrial dysfunction. Here, we review recent findings on the wide array of mechanisms that contribute to these mitocellular communication networks, spanning from well-studied messenger molecules to mitonuclear genetic interactions. Based on these observations and dev...
Source: ScienceNOW - November 13, 2019 Category: Science Authors: Mottis, A., Herzig, S., Auwerx, J. Tags: Cell Biology special/review Source Type: news
Oxygen deficiency rewires mitochondria
(Max-Planck-Gesellschaft) Researchers slow the growth of pancreatic tumor cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 11, 2019 Category: Biology Source Type: news
Mitochondria ’s activity in lung tumors could predict response to treatment
FINDINGSResearchers at theUCLA Jonsson Comprehensive Cancer Center andDavid Geffen School of Medicine at UCLA have identified a new biomarker that could indicate how likely someone is to respond to treatment for lung cancer. In a test using mice, the scientists found that the level of activity of the mitochondria in lung tumor cells could potentially predict who would respond favorably to a type of drug called a complex I inhibitor, which targets mitochondrial function — and that the mitochondria activity could be tracked noninvasively using a PET scan.The study was the first to use a noninvasive imaging technique to tra...
Source: UCLA Newsroom: Health Sciences - October 30, 2019 Category: Universities & Medical Training Source Type: news
Medical News Today: Scientists liken mitochondria to Tesla battery packs
Using high resolution microscopy, scientists show that mitochondria comprise many bioelectric units rather than a single one, as they previously thought. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 17, 2019 Category: Consumer Health News Tags: Biology / Biochemistry Source Type: news
Cells ’ mitochondria work much like Tesla battery packs, study finds
For years, scientists assumed that mitochondria — the energy-generating centers of living cells — worked much like household batteries, generating energy from a chemical reaction inside a single chamber or cell. Now, UCLA researchers have shown that mitochondria are instead made up of many individual bioelectric units that generate energy in an array, similar to a Tesla electric car battery that packs thousands of battery cells to manage energy safely and provide fast access to very high current.“Nobody had looked at this before because we were so locked into this way of thinking; the assumption was that one mitochon...
Source: UCLA Newsroom: Health Sciences - October 14, 2019 Category: Universities & Medical Training Source Type: news
Medical News Today: Is this how fructose worsens the effect of high fat diets?
A new mouse study reveals that adding fructose to high fat diets disrupts fat burning in the liver through effects on fat oxidation genes and mitochondria. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 5, 2019 Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
New technique reveals how mitochondria respond to exposures
<div class="rxbodyfield">NIEHS grantees developed a tool that showed how certain exposures in mitochondria led to damage to the ends of chromosomes, or telomeres.</div> (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - October 2, 2019 Category: Environmental Health Source Type: news
Medical News Today: Anxiety: Are mitochondria involved?
Scientists link stress to disruptions in energy metabolism in mice and humans who have panic disorder, a form of anxiety disorder. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 27, 2019 Category: Consumer Health News Tags: Anxiety / Stress Source Type: news
New results for organelle genome searches
As part of our ongoing effort to improve your search experience, we’ve made it easier for you to find the sequence of your favorite organelle genome plus all the information and data associated with it. To find organelle genomes, search … Continue reading → (Source: NCBI Insights)
Source: NCBI Insights - September 23, 2019 Category: Databases & Libraries Authors: NCBI Staff Tags: What's New chloroplasts mitochondria nucleotide Protein sequences Source Type: news
Study points to new drug target in fight against cancer
Researchers have identified a potential new drug target in the fight against cancer. In a study this week in the Proceedings of the National Academy of Sciences, an international team of researchers describe how a cancer-linked version of the protein mitoNEET can close the primary gateways in the outer surface of mitochondria, the "power plants" that supply cells with chemical energy. (Source: World Pharma News)
Source: World Pharma News - September 18, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
Tumor-derived TGF-{beta} inhibits mitochondrial respiration to suppress IFN-{gamma} production by human CD4+ T cells
Transforming growth factor–β (TGF-β) is produced by tumors, and increased amounts of this cytokine in the tumor microenvironment and serum are associated with poor patient survival. TGF-β–mediated suppression of antitumor T cell responses contributes to tumor growth and survival. However, TGF-β also has tumor-suppressive activity; thus, dissecting cell type–specific molecular effects may inform therapeutic strategies targeting this cytokine. Here, using human peripheral and tumor-associated lymphocytes, we investigated how tumor-derived TGF-β suppresses a key antitumor function of...
Source: Signal Transduction Knowledge Environment - September 16, 2019 Category: Science Authors: Dimeloe, S., Gubser, P., Loeliger, J., Frick, C., Develioglu, L., Fischer, M., Marquardsen, F., Bantug, G. R., Thommen, D., Lecoultre, Y., Zippelius, A., Langenkamp, A., Hess, C. Tags: STKE Research Articles Source Type: news
