Mitochondria and early-life adversity - Zitkovsky EK, Daniels TE, Tyrka AR.
Early-life adversity (ELA), which includes maltreatment, neglect, or severe trauma in childhood, increases the life-long risk for negative health outcomes. Mitochondria play a key role in the stress response and may be an important mechanism by which stres... (Source: SafetyLit)
Source: SafetyLit - January 25, 2021 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
New findings help explain how COVID-19 overpowers the immune system
Seeking to understand why COVID-19 is able to suppress the body's immune response, new research from the USC Leonard Davis School of Gerontology suggests that mitochondria are one of the first lines of defense against COVID-19 and identifies key differences in how SARS-CoV-2, the virus that causes COVID-19, interacts with mitochondrial genes when compared to other viruses. (Source: World Pharma News)
Source: World Pharma News - January 11, 2021 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
One in five brain cancers fueled by overactive mitochondria
(Columbia University Irving Medical Center) A new study has found that up to 20% of aggressive brain cancers are fueled by overactive mitochondria and new drugs in development may be able to starve the cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 11, 2021 Category: Cancer & Oncology Source Type: news
New findings help explain how COVID-19 overpowers the immune system
(University of Southern California) Seeking to understand why COVID-19 is able to suppress the body's immune response, new research from the USC Leonard Davis School of Gerontology suggests that mitochondria are one of the first lines of defense against COVID-19 and identifies key differences in how SARS-CoV-2, the virus that causes COVID-19, interacts with mitochondrial genes when compared to other viruses. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 8, 2021 Category: Infectious Diseases Source Type: news
UCLA scientists develop high-throughput mitochondria transfer device
(University of California - Los Angeles Health Sciences) Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 29, 2020 Category: International Medicine & Public Health Source Type: news
New drug inhibits the growth of cancer cells
(Max-Planck-Gesellschaft) Blocking gene expression in mitochondria in mice stops cancer cells from growing (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 22, 2020 Category: International Medicine & Public Health Source Type: news
Blood pressure drug may be key to increasing lifespan, new study shows
(Osaka City University) A stress response of mitochondria, the part of our cells that produce energy to power bodily functions, is important to a longer life. A team of scientists from Osaka City University, Japan, searched through a chemical " library " of existing drugs to find one that can activate this stress response in the worm Caenorhabditis elegans. They found that an anti-hypertension drug called metolazone prolongs C. elegans lifespan, marking the first step in developing anti-aging pharmaceuticals. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - December 18, 2020 Category: International Medicine & Public Health Source Type: news
Quality control in mitochondria
(Source: ScienceNOW)
Source: ScienceNOW - November 26, 2020 Category: Science Authors: Vinson, V. Tags: Biochemistry twis Source Type: news
Mitochondrial dysfunction, disease explored through prestigious award
<div class="rxbodyfield">Interactions between mitochondria and other organelles, and how disruptions may harm health, are the focus of a new project led by NIEHS.</div> (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - November 3, 2020 Category: Environmental Health Source Type: news
New tricks for old antibiotics
(Instituto Gulbenkian de Ciencia) The study published in the journal Immunity reveals that tetracyclines (broad spectre antibiotics), by partially inhibiting cell mitochondria activity, induce a compensatory response on the organism that decreases tissue damage caused during infection. This finding opens new doors in the field of disease tolerance and positions this group of antibiotics as potential adjuvant treatment for sepsis, due to their effects that go beyond the control of bacterial burden. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 22, 2020 Category: Infectious Diseases Source Type: news
Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial con...
Source: ScienceNOW - October 15, 2020 Category: Science Authors: Bosch, M., Sanchez-Alvarez, M., Fajardo, A., Kapetanovic, R., Steiner, B., Dutra, F., Moreira, L., Lopez, J. A., Campo, R., Mari, M., Morales-Paytuvi, F., Tort, O., Gubern, A., Templin, R. M., Curson, J. E. B., Martel, N., Catala, C., Lozano, F., Tebar, F Tags: Cell Biology, Online Only r-articles Source Type: news
Enzyme SSH1 impairs disposal of accumulating cellular garbage, leading to brain cell death
(University of South Florida (USF Health)) The protein p62 plays a major role in clearing misfolded tau proteins and dysfunctional mitochondria, the energy powerhouse in all cells including neurons. Neuroscientists at the University of South Florida Health (USF Health) Byrd Alzheimer's Center report for the first time that the protein phosphatase Slingshot-1, or SSH1 for short, disrupts p62's ability to function as an efficient 'garbage collector' and thereby impairs the disposal of both damaged tau and mitochondria leaking toxins. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 12, 2020 Category: International Medicine & Public Health Source Type: news
Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality
Conclusion(s): Aging is associated with worse outcomes in sepsis. Modulating Sirtuin activity is emerging as therapeutic agent in sepsis. HIF-alpha, levels of mitochondrial DNA, and other mitochondrial DAMP molecules may also serve as useful biomarker and need to be investigated. These mechanisms should be explored specifically for Covid-19-related sepsis. Understanding newly discovered regulatory mechanisms may lead to the development of novel diagnostic and therapeutic targets. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news
Gladstone investigator receives NIH Director's New Innovator Award
(Gladstone Institutes) The National Institutes of Health (NIH) has granted an NIH Director's New Innovator Award to Seth Shipman, PhD, assistant investigator at Gladstone Institutes. The award will support the development of innovative technologies to edit the DNA found in mitochondria--energy-producing structures within human cells. Shipman's efforts could lead to new treatments for a range of currently incurable diseases caused by mutations in mitochondrial DNA. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 6, 2020 Category: International Medicine & Public Health Source Type: news
Changes to epigenome driven by energy powerhouse of cells
<div class="rxbodyfield">NIEHS study shows that disruptions to mitochondria can alter how genes are expressed, with long-lasting ramifications.</div> (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - October 3, 2020 Category: Environmental Health Source Type: news
