Thyroid hormone receptor and ERR{alpha} coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function
Thyroid hormone receptor β1 (THRB1) and estrogen-related receptor α (ESRRA; also known as ERRα) both play important roles in mitochondrial activity. To understand their potential interactions, we performed transcriptome and ChIP-seq analyses and found that many genes that were co-regulated by both THRB1 and ESRRA were involved in mitochondrial metabolic pathways. These included oxidative phosphorylation (OXPHOS), the tricarboxylic acid (TCA) cycle, and β-oxidation of fatty acids. TH increased ESRRA expression and activity in a THRB1-dependent manner through the induction of the transcriptional coactiv...
Source: Signal Transduction Knowledge Environment - June 26, 2018 Category: Science Authors: Singh, B. K., Sinha, R. A., Tripathi, M., Mendoza, A., Ohba, K., Sy, J. A. C., Xie, S. Y., Zhou, J., Ho, J. P., Chang, C.-y., Wu, Y., Giguere, V., Bay, B.-H., Vanacker, J.-M., Ghosh, S., Gauthier, K., Hollenberg, A. N., McDonnell, D. P., Yen, P. M. Tags: STKE Research Articles Source Type: news
Small, Yet Powerful Mitochondria and Blood Stem Cells
Recent studies of blood stem cells highlight the importance of cellular components called mitochondria in determining how these cells function. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news
Medical News Today: How four cups of coffee might protect the heart
Caffeine is known to protect against heart disease and stroke. A new study finds the mechanism that underpins this protection, and mitochondria are key. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 22, 2018 Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
Medical News Today: Parkinson's: Vitamin B-3 may stop brain cell death
A Parkinson's study using human cells and a fly model found that a form of vitamin B-3 prevented the death of brain cells by preserving their mitochondria. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 8, 2018 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news
Parkinson's: Vitamin B-3 may stop brain cell death
A Parkinson's study using human cells and a fly model found that a form of vitamin B-3 prevented the death of brain cells by preserving their mitochondria. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - June 8, 2018 Category: Neurology Tags: Parkinson's Disease Source Type: news
Antioxidants developed by MSU scientists slow down senescence in plants
(Lomonosov Moscow State University) A team from the Faculty of Biology, MSU tested on plants mitochondria-targeted antioxidants developed in the university lab under the guidance of Academician Vladimir Skulachev. The tests showed slowdown of senescence processes and inhibition of cell death. The study was published in the Mitochondrion journal. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 8, 2018 Category: Biology Source Type: news
What would help or hinder patient participation in mitochondrial disease clinical trials?
As clinical trials gear up with the aim of attaining the first FDA-approved treatments for mitochondrial disease, a new study reports for the first time what patients and families say would motivate them for or against participating in such research trials. Based in malfunctions in mitochondria, the tiny structures within cells that act as biological batteries, mitochondrial disease is a highly variable collection of energy deficiency disorders that can affect nearly any and all organs and systems - at any age. (Source: World Pharma News)
Source: World Pharma News - June 7, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
Biomedical optics engineer Jesse Wilson named a Boettcher Investigator
(Colorado State University) Mitochondrial diseases are devastating illnesses caused by defects in cellular organelles called mitochondria. Their cells starved of energy, most stricken children die by age 12. There is no cure, and diagnosis can take months.Colorado State University biomedical engineer Jesse Wilson wants to change all of that. The assistant professor of electrical and computer engineering is proposing a radical new imaging technology that could diagnose mitochondrial defects in an instant. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 7, 2018 Category: International Medicine & Public Health Source Type: news
NIH scientists show how tularemia bacteria trick cells to cause disease
(NIH/National Institute of Allergy and Infectious Diseases) Francisella tularensis is the bacterium that causes tularemia, a life-threatening disease spread to humans via contact with an infected animal or through mosquito, tick or deer fly bites. NIAID scientists have unraveled the process by which the bacteria cause disease, finding that F. tularensis tricks host cell mitochondria, which produce energy for the cell, in two different phases of infection. These basic science findings could play a role in developing effective treatment strategies. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 30, 2018 Category: Infectious Diseases Source Type: news
Tasting with ATP and mitochondria
(Source: ScienceNOW)
Source: ScienceNOW - May 10, 2018 Category: Science Authors: Wong, W. Tags: twis Source Type: news
ONC201 kills breast cancer cells in vitro by targeting mitochondria
(Rapamycin Press) 'Our work identifies a novel mechanism of ONC201 cytotoxicity that is based on the disruption of mitochondrial function, leading to ATP depletion and cell death in cancer cells that are dependent on mitochondrial respiration. Our study also suggests that cancer cells that are dependent on glycolysis will be resistant to ONC201' Dr. Stanley Lipkowitz, Chief, Women's Malignancies Branch, NCI. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 8, 2018 Category: Cancer & Oncology Source Type: news
Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex
Conventional chemical synapses in the nervous system involve a presynaptic accumulation of neurotransmitter-containing vesicles, which fuse with the plasma membrane to release neurotransmitters that activate postsynaptic receptors. In taste buds, type II receptor cells do not have conventional synaptic features but nonetheless show regulated release of their afferent neurotransmitter, ATP, through a large-pore, voltage-gated channel, CALHM1. Immunohistochemistry revealed that CALHM1 was localized to points of contact between the receptor cells and sensory nerve fibers. Ultrastructural and super-resolution light microscopy ...
Source: Signal Transduction Knowledge Environment - May 8, 2018 Category: Science Authors: Romanov, R. A., Lasher, R. S., High, B., Savidge, L. E., Lawson, A., Rogachevskaja, O. A., Zhao, H., Rogachevsky, V. V., Bystrova, M. F., Churbanov, G. D., Adameyko, I., Harkany, T., Yang, R., Kidd, G. J., Marambaud, P., Kinnamon, J. C., Kolesnikov, S. S. Tags: STKE Research Articles Source Type: news
Highlight: A tasteful conversation with atypical mitochondria at atypical synapses
Atypical mitochondria produce ATP used as a neurotransmitter by type II taste cells to transduce sweet, bitter, or savory flavors. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 8, 2018 Category: Science Authors: Dubyak, G. R. Tags: STKE Editors ' Choice Source Type: news
'Digital snapshots' reveal the protein landscape of mitochondrial quality control
(Harvard Medical School) Harvard Medical School scientists developed a new technique to analyze, with unprecedented quantitative precision, how cells initiate the removal of defective mitochondria by the cell's autophagy, or 'self-eating,' system. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 3, 2018 Category: Biology Source Type: news
Mitochondria fight Toxoplasma for fat
(Source: ScienceNOW)
Source: ScienceNOW - May 3, 2018 Category: Science Authors: Hurtley, S. M. Tags: twil Source Type: news
